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Miscellaneous Neoplasia of the Ovary

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Practical Gynecologic Pathology

Part of the book series: Practical Anatomic Pathology ((PAP))

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Abstract

The ovary is a frequent target for metastatic carcinomas, particularly of the GI and breast primaries. They represent more than 5% of ovarian malignant epithelial tumors at surgery. Bilateral ovarian involvement, ovarian surface tumors, the presence of multiple discrete and heterogeneous parenchymal tumor nodules, and the presence of lymphovascular tumor thrombi are common features of metastatic carcinoma. It is important to note that metastatic carcinomas may simulate a primary ovarian carcinoma by paradoxical metamorphosis, including maturation into a low-grade appearance, gross and microscopic cystic appearance, microscopic follicle-like changes, and stromal luteinization. In rare occasions, the metastatic tumor may present before the primary carcinoma is clinically detectable. Generally, when an extraovarian carcinoma is present, every effort should be made to histologically compare with the ovarian tumor. While high stage lymphomas of other organs may frequently involve the ovary, primary ovarian lymphomas do occur. Small cell carcinoma of hypercalcemic type is an aggressive tumor of unknown cell origin.

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Abbreviations

DLBCL:

Diffuse large B-cell lymphoma

EAC:

Endometrioid adenocarcinoma

HPV:

Human papillomavirus

IHC:

Immunohistochemistry

LCNEC:

Large cell neuroendocrine carcinoma

MMMT:

Malignant mixed Mullerian tumor

SCNEC:

Small cell neuroendocrine carcinoma

SEIC:

Serous endometrial intraepithelial carcinoma

STIC:

Serous tubal intraepithelial carcinoma

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Authors and Affiliations

  1. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Pei Hui

  2. The Warren Alpert Medical School of Brown University, Staff Pathologist, Women and Infants Hospital, Division of Gynecologic and Breast Pathology, Providence, RI, USA

    Natalie Banet

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  1. Pei Hui
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  1. Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA

    Jian-Jun Wei

  2. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Pei Hui

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Hui, P., Banet, N. (2021). Miscellaneous Neoplasia of the Ovary. In: Wei, JJ., Hui, P. (eds) Practical Gynecologic Pathology. Practical Anatomic Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-68608-6_11

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