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Frontal Cortex

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The Neuropathology of Schizophrenia

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Abstract

Long suggested to be a primary area of disruption in schizophrenia, particularly in relation to the occurrence of psychosis, the frontal lobe has received considerable investigation. As with other regions, investigation into the frontal lobe has been focused on specific regions and found contradicting results. However, the overall pattern of changes from pathological research and imaging studies does suggest a strong trend of grey and white matter loss, particularly in the more dorsal prefrontal and superior and temporal areas. There seems little doubt that the pyramidal layers of frontal lobe structures are the focus of considerable change in schizophrenia, although the precise nature of this requires more focused study to elucidate. More recently, the application of advanced molecular techniques has found key candidates for association in psychosis and schizophrenia as well as cognitive behaviours in general, particularly in the dlPFC and OFC. Many of these schizophrenia-associated loci, SNPs and receptor changes are involved in metabolic regulation, suggesting a possible new direction of schizophrenia research in these regions and showing the importance or further development of molecular biology in conventional neuropathology.

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  1. Francis Fraser Clinic, Hammersmith Hospital, London, UK

    Matthew Williams

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Williams, M. (2021). Frontal Cortex. In: Williams, M. (eds) The Neuropathology of Schizophrenia. Springer, Cham. https://doi.org/10.1007/978-3-030-68308-5_4

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  • DOI: https://doi.org/10.1007/978-3-030-68308-5_4

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