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Anatomy Prior Based U-net for Pathology Segmentation with Attention

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Statistical Atlases and Computational Models of the Heart. M&Ms and EMIDEC Challenges (STACOM 2020)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 12592))

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Abstract

Pathological area segmentation in cardiac magnetic resonance (MR) images plays a vital role in the clinical diagnosis of cardiovascular diseases. Because of the irregular shape and small area, pathological segmentation has always been a challenging task. We propose an anatomy prior based framework, which combines the U-net segmentation network with the attention technique. Leveraging the fact that the pathology is inclusive, we propose a neighborhood penalty strategy to gauge the inclusion relationship between the myocardium and the myocardial infarction and no-reflow areas. This neighborhood penalty strategy can be applied to any two labels with inclusive relationships (such as the whole infarction and myocardium, etc.) to form a neighboring loss. The proposed framework is evaluated on the EMIDEC dataset. Results show that our framework is effective in pathological area segmentation.

This work was funded by the National Natural Science Foundation of China (Grant No. 61971142), and Shanghai Municipal Science and Technology Major Project (Grant No. 2017SHZDZX01).

Y. Zhou and K. Zhang—Contributed equally.

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References

  1. Bernard, O., et al.: Deep learning techniques for automatic MRI cardiac multi-structures segmentation and diagnosis: is the problem solved? IEEE Trans. Med. Imaging 37(11), 2514–2525 (2018)

    Article  Google Scholar 

  2. Duan, J., et al.: Automatic 3D bi-ventricular segmentation of cardiac images by a shape-refined multi-task deep learning approach. IEEE Trans. Med. Imaging 38(9), 2151–2164 (2019)

    Article  Google Scholar 

  3. Huertas-Vazquez, A., Leon-Mimila, P., Wang, J.: Relevance of multi-omics studies in cardiovascular diseases. Front. Cardiovasc. Med. 6, 91 (2019)

    Google Scholar 

  4. Lalande, A., et al.: Emidec: a database usable for the automatic evaluation of myocardial infarction from delayed-enhancement cardiac MRI. Data 5(4), 89 (2020)

    Article  Google Scholar 

  5. Qian, X., Lin, Y., Zhao, Y., Wang, J., Liu, J., Zhuang, X.: Segmentation of myocardium from cardiac MR images using a novel dynamic programming based segmentation method. Med. Phys. 42(3), 1424–1435 (2015)

    Article  Google Scholar 

  6. Sun, H., Frangi, A.F., Wang, H., Sukno, F.M., Tobon-Gomez, C., Yushkevich, P.A.: Automatic cardiac MRI segmentation using a biventricular deformable medial model. In: Jiang, T., Navab, N., Pluim, J.P.W., Viergever, M.A. (eds.) MICCAI 2010, Part I. LNCS, vol. 6361, pp. 468–475. Springer, Heidelberg (2010). https://doi.org/10.1007/978-3-642-15705-9_57

    Chapter  Google Scholar 

  7. Woo, S., Park, J., Lee, J.-Y., Kweon, I.S.: CBAM: convolutional block attention module. In: Ferrari, V., Hebert, M., Sminchisescu, C., Weiss, Y. (eds.) ECCV 2018, Part VII. LNCS, vol. 11211, pp. 3–19. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-01234-2_1

    Chapter  Google Scholar 

  8. Xu, C., Howey, J., Ohorodnyk, P., Roth, M., Zhang, H., Li, S.: Segmentation and quantification of infarction without contrast agents via spatiotemporal generative adversarial learning. Med. Image Anal. 59, 101568 (2020)

    Article  Google Scholar 

  9. Xu, C., Xu, L., Brahm, G., Zhang, H., Li, S.: MuTGAN: simultaneous segmentation and quantification of myocardial infarction without contrast agents via joint adversarial learning. In: Frangi, A.F., Schnabel, J.A., Davatzikos, C., Alberola-López, C., Fichtinger, G. (eds.) MICCAI 2018, Part II. LNCS, vol. 11071, pp. 525–534. Springer, Cham (2018). https://doi.org/10.1007/978-3-030-00934-2_59

    Chapter  Google Scholar 

  10. Zhang, D., et al.: A multi-level convolutional LSTM model for the segmentation of left ventricle myocardium in infarcted porcine cine MR images. In: 2018 IEEE 15th International Symposium on Biomedical Imaging (ISBI 2018), pp. 470–473. IEEE (2018)

    Google Scholar 

  11. Zhang, H., Cisse, M., Dauphin, Y.N., Lopez-Paz, D.: mixup: beyond empirical risk minimization. arXiv preprint arXiv:1710.09412 (2017)

  12. Zhuang, X.: Multivariate mixture model for cardiac segmentation from multi-sequence MRI. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016, Part II. LNCS, vol. 9901, pp. 581–588. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-46723-8_67

    Chapter  Google Scholar 

  13. Zhuang, X.: Multivariate mixture model for myocardial segmentation combining multi-source images. IEEE Trans. Pattern Anal. Mach. Intell. 41(12), 2933–2946 (2019)

    Article  Google Scholar 

  14. Zhuang, X., Rhode, K.S., Razavi, R.S., Hawkes, D.J., Ourselin, S.: A registration-based propagation framework for automatic whole heart segmentation of cardiac mri. IEEE Trans. Med. Imaging 29(9), 1612–1625 (2010)

    Article  Google Scholar 

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Correspondence to Xiahai Zhuang .

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Zhou, Y., Zhang, K., Luo, X., Wang, S., Zhuang, X. (2021). Anatomy Prior Based U-net for Pathology Segmentation with Attention. In: Puyol Anton, E., et al. Statistical Atlases and Computational Models of the Heart. M&Ms and EMIDEC Challenges. STACOM 2020. Lecture Notes in Computer Science(), vol 12592. Springer, Cham. https://doi.org/10.1007/978-3-030-68107-4_41

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  • DOI: https://doi.org/10.1007/978-3-030-68107-4_41

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-68106-7

  • Online ISBN: 978-3-030-68107-4

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