Abstract
Current federal research misconduct regulations put universities in charge of investigating allegations made against their own faculty. The central thesis of this book is that conflict of interest prevents universities from properly carrying out their charge to investigate falsification of research. Universities, and specifically faculty committees, are poorly equipped to prove intentional or reckless behavior on the part of faculty respondents. Yet, failure to meet all the conditions of research misconduct leads to exoneration, even of those who have falsified data. A corollary is that the confidentiality clause in federal regulations has been distorted so that it is used to protect universities, not the informant or respondent to allegations as originally intended. The conflicts are illustrated by a specific example, in which two scientists managed to evade judgment for nine years by using legal pressure and other influence. The federal regulations were written with the assumption that science would be a significant guiding principle in the investigative process. In practice, scientific considerations are less important than the funding status, connections and litigiousness of respondents. These failures of the regulation can lead to serious harm to the reputation and professional standing of the informant.
Science is a search for the truth, that is the effort to understand the world: it involves the rejection of bias, of dogma, of revelation, but not the rejection of morality.
–Linus Pauling
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References
Lancaster, C. 2015. The Acid Test for Biological Science: STAP Cells, Trust, and Replication. Science and Engineering Ethics 22: 147–167.
Hawkes, N. 2014. Investigation into Stem Cell Research Claims Finds Scientific Misconduct by Researcher and Lack of Supervision by Coauthors. British Medical Journal 348: g2563.
Normile, D. 2014. Stem Cell Research RIKEN Panel Finds Misconduct in Controversial Paper. Science 344: 23–23.
Carpenter, S. 2012. Harvard Psychology Researcher Committed Fraud, U.S. Investigation Concludes. ScienceInsider, September 6.
Judson, H.F. 2004. The Great Betrayal: Fraud in Science. Orlando: Harcourt Press.
Broad, W., and N. Wade. 1983. Betrayers of the Truth: Fraud and Deceit in the Halls of Science. London: Century Publishing.
Reich, E. 2009. Plastic Fantastic. New York: Palgrave Macmillan.
Reich, E.S. 2007. Disputed Inquiry Clears Bubble-Fusion Engineer. Nature 445: 690–691.
Chung, S., et al. 2013. The Formation of Pd Nanocrystals from Pd2(dba)3 Microcrystals. Particle & Particle Systems Characterization 30: 280–286.
Franzen, S., M. Cerruti, D.N. Leonard, and G. Duscher. 2007. The Role of Selection Pressure in RNA-Mediated Evolutionary Materials Synthesis. Journal of the American Chemical Society 129: 15340–15346.
Franzen, S., and D.N. Leonard. 2011. Analysis of RNA-Mediated Materials Synthesis Using Magnetic Selection. Journal of Physical Chemistry C 115: 9335–9343.
Leonard, D.N., M. Cerruti, G. Duscher, and S. Franzen. 2008. Interfacial and Solvent Effects Govern the Formation of tris(dibenzylidenacetone)dipalladium(0) Microstructures. Langmuir 24: 7803–7809.
Leonard, D.N., G. Duscher, and S. Franzen. 2008. Eletter Concerning “RNA-Mediated Metal-Metal Bond Formation in the Synthesis of Hexagonal Palladium Nanoparticles”. Science e-Letter.
Leonard, D.N., and S. Franzen. 2009. Is Pd-2(DBA)(3) a Feasible Precursor for the Synthesis of Pd Nanoparticles? Journal of Physical Chemistry C 113: 12706–12714.
Gugliotti, L.A., D.L. Feldheim, and B.E. Eaton. 2004. RNA-Mediated Metal-Metal Bond Formation in the Synthesis of Hexagonal Palladium Nanoparticles. Science 304: 850–852.
Neff, J. 2014. In notebook at NCSU, a ‘smoking gun’. News and Observer, January 20.
Eaton, B., D. Feldheim, M. Dolska, and L. Gugliotti. 2003. Novel Methods of Inorganic Compound Discovery and Synthesis U.S. Patent Application US 20050136439 A1.
Neff, J. 2014. NC State Professor Uncovers Problems in Lab Journal. New and Observer, January 19.
———. 2014. Congressmen Push NCSU on Case of Flawed Research. Raleigh News and Observer, July 17.
———. 2016. Formesr NCSU Scientists Reprimanded, Lose Future Funding over ‘Misleading’ Research. News and Observer, January 8.
Kuta, S. 2016. National Science Foundation Reprimands CU-Boulder Prof over Research Practices. Daily Camera, November 1.
Borman, S. 2016. Nanoparticle Synthesis Paper Retracted After 12 Years. Chemical & Engineering News 94: 37–38.
Mervis, J. 2016. NSF Breaks New Ground in Reprimanding Authors of Flawed Science Paper. ScienceInsider, February 4.
Kuta, S. 2014. CU-Boulder Scientists Speak Out on Research Misconduct Claim. Boulder Daily Camera, February 7.
Franzen, S., and Leonard, D.N.A. 2010. Critical Assessment of RNA-Mediated Materials Synthesis. Material Research Society Symposium Proceedings 1271: 1272-PP1204-1203.
Franzen, S. 2011. Determination of the Solubility Limit of Tris(dibenzylideneacetone) dipalladium(0) in Tetrahydrofuran/Water Mixtures. Journal of Chemical Education 88: 619–623.
Reich, E.S. 2011. Acrimony over Nanoconstruction. Nature, August 23.
N.S. Foundation. 2015. https://www.nsf.gov/oig/case-closeout/A06110054.pdf. A06110054.
Gugliotti, L.A. 2006. North Carolina State University.
Gugliotti, L.A., D.L. Feldheim, and B.E. Eaton. 2005. RNA-Mediated Control of Metal Nanoparticle Shape. Journal of American Chemical Society 127: 17814–17818.
Liu, D.G., et al. 2006. RNA-Mediated Synthesis of Palladium Nanoparticles on Au Surfaces. Langmuir 22: 5862–5866.
Franzen, S. 2013. Comment on ‘Cooperativity Between Two Selected RNA Pdases in the Synthesis of Pd Nanoparticles’ by J. L. Rouge et al. Journal of Materials Chemistry 2010, 20: 8394–8398. Journal of Materials Chemistry B 1: 6339–6341.
Tuerk, C., and L. Gold. 1990. Systematic Evolution of Ligands by Exponential Enrichment – RNA Ligands to Bacteriophage-T4 DNA-Polymerase. Science 249: 505–510.
Ellington, A.D., and J.W. Szostak. 1990. In vitro Selection of RNA Molecules that Bind Specific Ligands. Nature 346: 818–822.
Gold, L. 2004. Photoaptamer-Based High-Density Proteomic Arrays. Molecular & Cellular Proteomics 3: S2–S2.
Gold, L., et al. 2010. Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery. Plos One 5.
———. 2010. Aptamers and the RNA World, Past and Present. Cold Spring Harbor Perspectives in Biology. https://doi.org/10.1101/cshperspect.a003582.
Golden, M.C., B.D. Collins, M.C. Willis, and T.H. Koch. 2000. Diagnostic Potential of PhotoSELEX-Evolved ssDNA Aptamers. Journal of Biotechnology 81: 167–178.
Agresti, J.J., B.T. Kelly, A. Jaschke, and A.D. Griffiths. 2005. Selection of Ribozymes that Catalyse Multiple-Turnover Diels-Alder Cycloadditions by Using in vitro Compartmentalization. Proceedings of the National Academy of Sciences of the United States America 102: 16170–16175.
Furtig, B., et al. 2007. Time-Resolved NMR Studies of RNA Folding. Biopolymers 86: 360–383.
Keiper, S., D. Bebenroth, B. Seelig, E. Westhof, and A. Jaschke. 2004. Architecture of a Diels-Alderase Ribozyme with a Preformed Catalytic Pocket. Chemical Biology 11: 1217–1227.
Kisseleva, N., S. Kraut, A. Jaschke, and O. Schiemann. 2007. Characterizing Multiple Metal Ion Binding Sites Within a Ribozyme by Cadmium-Induced EPR Silencing. Hfsp Journal 1: 127–136.
Manoharan, V., B. Furtig, A. Jaschke, and H. Schwalbe. 2009. Metal-Induced Folding of Diels-Alderase Ribozymes Studied by Static and Time-Resolved NMR Spectroscopy. Journal of American Chemical Society 131: 6261–6270.
Jia, T.Z., A.C. Fahrenbach, N.P. Kamat, K.P. Adamala, and J.W. Szostak. 2016. Oligoarginine Peptides Slow Strand Annealing and Assist Non-enzymatic RNA Replication. Nature Chemistry 8: 915–921.
———. 2017. Oligoarginine Peptides Slow Strand Annealing and Assist Non-enzymatic RNA Replication (Retraction of Vol 8, Pg 915, 2016). Nature Chemistry 9: 1286–1286.
Rybarczyk, A., et al. 2015. New in Silico Approach to Assessing RNA Secondary Structures with Non-canonical Base Pairs. BMC Bioinformatics 16: 276.
Cech, T.R. 2012. The RNA Worlds in Context. Cold Spring Harbor Perspectives in Biology 4.
Kruger, K., et al. 1982. Self-Splicing RNA – Auto-Excision and Auto-Cyclization of the Ribosomal-RNA Intervening Sequence of Tetrahymena. Cell 31: 147–157.
Joyce, G.F. 1989. Amplification, Mutation and Selection of Catalytic RNA. Gene 82: 83–87.
Cech, T.R. 2013. How a Chemist Looks at RNA. Angewandte Chemie-International Edition 52: 75–78.
Chung, S.W., et al. 2008. Scanning Probe-Based Fabrication of 3D Nanostructures via Affinity Templates, Functional RNA, and Meniscus-Mediated Surface Remodeling. Scanning 30: 159–171.
Jolly, J. 2017. Why I Failed to Catch Canada’s Worst Serial Killer. BBC World Service, June 1.
Adamiak, R.W., and P. Gornicki. 1985. Hypermodified Nucleosides of Transfer-RNA – Synthesis, Chemistry and Structural Features of Biological Interest. Progress in Nucleic Acid Research and Molecular Biology 32: 27–74.
Antczak, M., et al. 2016. New functionality of RNAComposer: An Application to Shape the Axis of miR160 Precursor Structure. Acta Biochimica Polonica 63: 737–744.
Biesiada, M., K. Pachulska-Wieczorek, R.W. Adamiak, and K.J. Purzycka. 2016. RNAComposer and RNA 3D Structure Prediction for Nanotechnology. Methods 103: 120–127.
Cieslak, M., J. Szymanski, R.W. Adamiak, and C.S. Cierniewski. 2003. Structural Rearrangements of the 10-23 DNAzyme to Beta 3 Integrin Subunit mRNA Induced by Cations and Their Relations to the Catalytic Activity. Journal of Biological Chemistry 278: 47987–47996.
Heydenreich, A., et al. 1993. The Complex Between Ribonuclease T1 and 3′GMP Suggests Geometry of Enzymatic Reaction Path – An X-ray Study. European Journal of Biochemistry 218: 1005–1012.
Lukasiak, P., et al. 2015. RNAssess-a Web Server for Quality Assessment of RNA 3D Structures. Nucleic Acids Research 43: W502–W506.
Olejniczak, M., et al. 2002. The bulge region of HIV-1 TAR RNA Binds Metal Ions in Solution. Nucleic Acids Research 30: 4241–4249.
Pachulska-Wieczorek, K., L. Blaszczyk, M. Biesiada, R.W. Adamiak, and K.J. Purzycka. 2016. The Matrix Domain Contributes to the Nucleic Acid Chaperone Activity of HIV-2 Gag. Retrovirology 13: 18.
Popenda, M., et al. 2012. Automated 3D Structure Composition for Large RNAs. Nucleic Acids Research 40: e112.
Purzycka, K.J., et al. 2015. Automated 3D RNA Structure Prediction Using the RNAComposer Method for Riboswitches. In Computational Methods for Understanding Riboswitches, ed. S.J. Chen and D.H. Burke Aguero, vol. 553, 3–34. Amsterdam: Elsevier.
Popenda, M., J. Milecki, and R.W. Adamiak. 2004. High Salt Solution Structure of a Left-Handed RNA Double Helix. Nucleic Acids Research 32: 4044–4054.
Gugliotti, L.A., D.L. Feldheim, and B.E. Eaton. 2009. RNA-Mediated Control of Metal Nanoparticle Shape (vol 127, pg 17814, 2005). Journal of the American Chemical Society 131: 11634–11634.
Harvey, P.D., F. Adar, and H.B. Gray. 1989. Spectroscopic Properties of Binuclear Palladium(0) and Platinum(0) Dibenzylideneacetone Complexes. Journal of American Chemical Society 111: 1312–1315.
Gugliotti, L.A., D.L. Feldheim, and B.E. Eaton. 2008. Eletter Concerning “RNA-Mediated Metal-Metal Bond Formation in the Synthesis of Hexagonal Palladium Nanoparticles”. Science Eletter.
Rouge, J.L., C.J. Ackerson, D.L. Feldheim, and B.E. Eaton. 2010. Cooperativity Between Two Selected RNA Pdases in the Synthesis of Pd Nanoparticles. Journal of Materials Chemistry 20: 8394–8398.
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Franzen, S. (2021). Evolution in a Test Tube. In: University Responsibility for the Adjudication of Research Misconduct. Springer, Cham. https://doi.org/10.1007/978-3-030-68063-3_1
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