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Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry

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Cellular Biology of the Endoplasmic Reticulum

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 59))

Abstract

The endoplasmic reticulum (ER) Ca2+ sensor stromal interaction molecule 1 (STIM1) interacts with ORAI Ca2+ channels at the plasma membrane to regulate immune and muscle cell function. The conformational changes underlying STIM1 activation, translocation, and ORAI1 trapping and gating, are stringently regulated by post-translational modifications and accessory proteins. Here, we review the recent progress in the identification and characterization of ER and cytosolic proteins interacting with STIM1 to control its activation and deactivation during store-operated Ca2+ entry (SOCE).

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Abbreviations

Aa:

Amino acid

AMPAR:

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor

ANO8:

Anoctamin 8

APC:

Adenomatous polyposis coli

BAG3:

B-cell lymphoma 2-associated athanogene 3

BMM:

Bone marrow macrophage

CAD:

Channel activating domain

CC1α1:

Coiled-coil

CLCA2:

Chloride channel accessory protein 2

CRAC:

Ca2+-release-activated channel

CRACR2:

Ca2+ release-activated Ca2+ channel regulator 2A

CTID:

C-terminal inhibitory domain

EB1:

Microtubule-associated protein RP/EB family member 1

EFHB:

EF-hand domain family member B

EM:

Electron microscopy

ER:

Endoplasmic reticulum

ERGIC:

ER/ER-Golgi intermediate compartment

FCDI/SCDI:

Fast Ca2+-dependent inactivation/slow Ca2+-dependent inactivation

FRET:

Förster resonance energy transfer

GST:

Glutathione S-transferase

IP3:

Inositol triphosphate

IRF3:

Interferon regulatory factor 3

ITPR:

Inositol triphosphate receptor

MBP:

Myelin basic protein

MCS:

Membrane contact site

MHCI:

Major histocompatibility complex class I

NFAT:

Nuclear factor of activated T-cells

NFATc1:

Nuclear factor of activated T-cells, cytoplasmic 1

NMDAR:

N-methyl-D-aspartate receptor

NSF:

N-ethlmaleimide-sensitive factor

PDIA3:

Protein disulfide-isomerase A3

PIP2:

Phosphatidylinositol-4, 5-bisphophate

PLCγ2:

Phospholipase C gamma-2

PM:

Plasma membrane

PMCA:

Plasma membrane Ca2+ ATPase

PMP2:

Peripheral myelin protein 22

POST:

Partner of STIM1

PRX-4:

Peroxiredoxin-4

SAM:

Sterile alpha motif

SARAF:

SOCE-associated regulatory factor

SNARE:

Soluble NSF-attachment protein receptor

SOAR:

STIM/Orai activating region

α-SNAP:

N-ethylmaleimide-sensitive factor attachment protein alpha

σ1R/σ2R:

Sigma 1 receptor/sigma 2 receptor

SOCE:

Associated regulatory factor

SERCA:

Sarco/endoplasmic reticulum Ca2+-ATPase

SOCE:

Store-operated Ca2+ entry

STIMATE:

STIM-activating enhancer

STIM1:

Stromal interaction molecule 1

STING:

The stimulator of interferon genes

SURF4:

Surfeit locus protein 4

TBK1:

TANK-binding kinase 1

TIRF:

Total internal reflection fluorescence

TLR:

Toll-like receptors

TMEM178:

A transmembrane protein 178

TRPC:

Transient receptor potential channel

TRPML1:

Transient receptor potential mucolipin 1

UNC93B1:

Un-coordinated 93 homologue B1

VCGGs:

Voltage-gated Ca2+ channels

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Acknowledgments

ND research is financed by SNF grant N° 31000-189042.

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Correspondence to Nicolas Demaurex .

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Wang, WA., Demaurex, N. (2021). Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry. In: Agellon, L.B., Michalak, M. (eds) Cellular Biology of the Endoplasmic Reticulum . Progress in Molecular and Subcellular Biology, vol 59. Springer, Cham. https://doi.org/10.1007/978-3-030-67696-4_4

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