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Perivascular Inflammation and Extracellular Matrix Alterations in Blood-Brain Barrier Dysfunction and Epilepsy

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Inflammation and Epilepsy: New Vistas

Part of the book series: Progress in Inflammation Research ((PIR,volume 88))

Abstract

The blood-brain barrier (BBB) is important to maintain brain homeostasis, which is crucial for the functionality of neuronal networks. BBB dysfunction is observed in several neurological diseases, including epilepsy. Prolonged BBB dysfunction and subsequent perivascular inflammation as well as alterations in the extracellular matrix (ECM) play an important role in epileptogenesis. In this chapter we aim to give an overview of the processes involved in BBB dysfunction and epileptogenesis and provide evidence from animal as well as from human studies. We will focus on modulators of BBB function including specific cell types, inflammatory mediators as well as ECM molecules. Furthermore, we will discuss new therapeutic targets and the results of intervention studies that are important for the development of novel therapeutic approaches in epilepsy.

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Authors and Affiliations

  1. Department of (Neuro)pathology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

    D. W. M. Broekaart, A. Korotkov & E. A. van Vliet

  2. Swammerdam Institute for Life Sciences, Center for Neuroscience, University of Amsterdam, Amsterdam, The Netherlands

    J. A. Gorter & E. A. van Vliet

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  1. D. W. M. Broekaart
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  2. A. Korotkov
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  3. J. A. Gorter
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  4. E. A. van Vliet
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Correspondence to E. A. van Vliet .

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Editors and Affiliations

  1. Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA

    Damir Janigro

  2. INSERM, Strasbourg, France

    Astrid Nehlig

  3. Cerebrovascular and Glia Research, Department of Neuroscience, Institute of Functional Genomics (UMR 5203 CNRS – U 1191 INSERM, University of Montpellier), Montpellier, France

    Nicola Marchi

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Broekaart, D.W.M., Korotkov, A., Gorter, J.A., van Vliet, E.A. (2021). Perivascular Inflammation and Extracellular Matrix Alterations in Blood-Brain Barrier Dysfunction and Epilepsy. In: Janigro, D., Nehlig, A., Marchi, N. (eds) Inflammation and Epilepsy: New Vistas. Progress in Inflammation Research, vol 88. Springer, Cham. https://doi.org/10.1007/978-3-030-67403-8_4

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