Skip to main content

Endoscopic Resection of Clival Chordoma

  • Chapter
  • First Online:
Rhinology and Anterior Skull Base Surgery

Abstract

Clival chordomas are rare tumours with a notochordal origin that are classically multilocular gelatinous lesions. Due to their location, endoscopic endonasal resection is an option to optimize extent of resection whilst also balancing risk to critical neurovascular structures. Nonetheless, patients may be at high risk of recurrence therefore the potential for adjuvant treatment with radiotherapy or proton beam therapy should always be considered.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Bibliography

  1. Anagiotos A, Preuss SF, Drebber U, Jumah MD. Multiple craniocervical chordomas presenting as a parapharyngeal mass. Head Neck. 2013;35:E325–7.

    Article  Google Scholar 

  2. McMaster ML, Goldstein AM, Bromley CM, Ishibe N, Parry DM. Chordoma: incidence and survival patterns in the United States, 1973-1995. Cancer Causes Control. 2001;12:1–11.

    Article  CAS  Google Scholar 

  3. Campbell RG, Prevedello DM, Filho LD, Otto BA, Carrau RL. Contemporary management of clival chordomas. Curr Opin Otolaryngol Head Neck Surg. 2015;23:153–61.

    Article  Google Scholar 

  4. Rhoton AL. The Cerebellar Arteries. Neurosurgery. 2000;47:S29–68.

    PubMed  Google Scholar 

  5. Sommer J. Building a global consensus approach to chordoma: a position paper from the medical and patient community. Lancet Oncol. 2015;16:e71–83.

    Article  Google Scholar 

  6. Fletcher CDM, World Health Organization, International Agency for Research on Cancer. WHO classification of tumours of soft tissue and bone: IARC Press; 2013.

    Google Scholar 

  7. Vujovic S, Henderson S, Presneau N, Odell E, Jacques T, Tirabosco R, Boshoff C, Flanagan A. Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas. J Pathol. 2006;209:157–65.

    Article  CAS  Google Scholar 

  8. Wang EW, Gardner PA, Zanation AM. International consensus statement on endoscopic skull-base surgery: executive summary. Int Forum Allergy Rhinol. 2019;9:S127–44.

    PubMed  Google Scholar 

  9. Metwali H, Samii A, Gerganov V, Giordano M, Fahlbusch R, Samii M. The significance of intraoperative magnetic resonance imaging in resection of skull base chordomas. World Neurosurg. 2019;128:e185–94.

    Article  Google Scholar 

  10. Mendenhall WM, Mendenhall CM, Lewis SB, Villaret DB, Price Mendenhall N. Skull base chordoma. Head Neck. 2005;27:159–65.

    Article  Google Scholar 

  11. Meng T, Jin J, Jiang C, Huang R, Yin H, Song D, Cheng L. Molecular targeted therapy in the treatment of chordoma: a systematic review. Front Oncol. 2019;9:30.

    Article  Google Scholar 

  12. QUILT-3.011 Phase 2 Yeast-Brachyury Vaccine Chordoma - Full Text View - ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02383498. Accessed 5 Feb 2020.

  13. Gröschel S. Defective homologous recombination DNA repair as therapeutic target in advanced chordoma. https://doi.org/10.1038/s41467-019-09633-9

  14. Cappabianca P, Cavallo LM, De Divitiis O, Esposito F. Midline skull base surgery.

    Google Scholar 

  15. Al-Mefty O, Borba LAB. Skull base chordomas: a management challenge. J Neurosurg. 1997;86:182–9.

    Article  CAS  Google Scholar 

  16. Henry LE, Haugen TW, Rassekh CH, Adappa ND, Weinstein GS, O’Malley BW. A novel transpalatal-transoral robotic surgery approach to clival chordomas extending into the nasopharynx. Head Neck. 2019;41:hed.25747.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vinay Varadarajan .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Fountain, D.M. et al. (2021). Endoscopic Resection of Clival Chordoma. In: Stavrakas, M., Khalil, H.S. (eds) Rhinology and Anterior Skull Base Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-66865-5_32

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-66865-5_32

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-66864-8

  • Online ISBN: 978-3-030-66865-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics