Abstract
This chapter discusses the common congenital malformations and diseases occurring in the perinatal period. Paediatric neuropathology is a highly subspecialised field of neuropathology and a good knowledge of the normal developmental processes and the ability to distinguish normal from abnormal for a particular age is essential for accurate interpretation of gross and microscopic findings. The way the developing nervous system responds to an injury varies during different stages of development. One clinical importance of recognising these conditions (especially malformations) lies in guiding genetic counselling for family members.
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References
Kalter H. Five-decade international trends in the relation of perinatal mortality and congenital malformations: stillbirth and neonatal death compared. Int J Epidemiol. 1991;20(1):173–9.
Nevin NC, Johnston WP, Merrett JD. Influence of social class on the risk of recurrence of anencephalus and spina bifida. Dev Med Child Neurol. 1981;23(2):155–9.
De-Regil LM, Fernandez-Gaxiola AC, Dowswell T, Pena-Rosas JP. Effects and safety of periconceptional folate supplementation for preventing birth defects. Cochrane Database Syst Rev. 2010;10:CD007950.
Greene NDE, Leung K-Y, Gay V, Burren K, Mills K, Chitty LS, et al. Inositol for the prevention of neural tube defects: a pilot randomised controlled trial. Br J Nutr. 2016;115:974–83.
Rubenstein JL, Beachy PA. Patterning of the embryonic forebrain. Curr Opin Neurobiol. 1998;8(1):18–26.
Dale JK, Vesque C, Lints TJ, Sampath TK, Furley A, Dodd J, et al. Cooperation of BMP7 and SHH in the induction of forebrain ventral midline cells by prechordal mesoderm. Cell. 1997;90(2):257–69.
Hayhurst M, McConnell SK. Mouse models of holoprosencephaly. Curr Opin Neurol. 2003;16(2):135–41.
Tekendo-Ngongang C, Muenke M, Kruzka P. Holoprosencephaly overview. In: GeneReviews [Internet]. Seattle, WA: University of Washington; 2020. 1993–2000.
Tan AP, Chong WK, Mankad K. Comprehensive genotype-phenotype correlation in lissencephaly. Quant Imaging Med Surg. 2018;8(7):673–93.
Ghazi-Birry HS, Brown WR, Moody DM, Challa VR, Block SM, Reboussin DM. Human germinal matrix: venous origin of hemorrhage and vascular characteristics. AJNR Am J Neuroradiol. 1997;18(2):219–29.
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Hilton, D.A., Shivane, A.G. (2021). Paediatric Diseases. In: Neuropathology Simplified. Springer, Cham. https://doi.org/10.1007/978-3-030-66830-3_14
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DOI: https://doi.org/10.1007/978-3-030-66830-3_14
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