Abstract
Neurodegenerative disorders have become one of the most important group of diseases in terms of disability and socioeconomic consequence to society. Our understanding of the pathogenesis of these disorders and their classification has increased dramatically in the last few years. This chapter describes the classification, pathogenesis and pathology of the different neurodegenerative disorders.
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References
Jaunmuktane Z, Brandner S. The role of prion-like mechanisms in neurodegenerative diseases. Neuropathol Appl Neurobiol. 2020;46(6):522–45.
Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease. Nat Genet. 2009;41(10):1094–9.
Bu G. Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy. Nat Rev Neurosci. 2009;10(5):333–44.
Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 1991;82(4):239–59.
Gearing M, Mirra SS, Hedreen JC, Sumi SM, Hansen LA, Heyman A. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part X. Neuropathology confirmation of the clinical diagnosis of Alzheimer’s disease. Neurology. 1995;45(3 Pt 1):461–6.
Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C, et al. Age, neuropathology, and dementia. N Engl J Med. 2009;360(22):2302–9.
Nicoll JAR, Buckland GR, Harrison CH, Page A, et al. Persistent neuropathological effects 14 years following amyloid ß-immunization in Alzheimer’s disease. Brain. 2019;142:2113–26.
Foutz A, Appleby BS, Hamlin C, et al. Diagnostic and prognostic value of human prion detection in cerebrospinal fluid. Ann Neurol. 2017;81(1):79–92.
Parchi P, Strammiello R, Notari S, Giese A, Langeveld JP, Ladogana A, et al. Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification. Acta Neuropathol. 2009;118(5):659–71.
Hilton D, Stephens M, Kirk L, Edwards P, Potter R, Zajicek J, et al. Accumulation of alpha-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease. Acta Neuropathol. 2014;127(2):235–41.
Klingelhoefer L, Reichmann H. Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors. Nat Rev Neurol. 2015;11:625–36.
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Hilton, D.A., Shivane, A.G. (2021). Neurodegenerative Disorders. In: Neuropathology Simplified. Springer, Cham. https://doi.org/10.1007/978-3-030-66830-3_12
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DOI: https://doi.org/10.1007/978-3-030-66830-3_12
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