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Use of Plant-Derived Natural Products in Sleep Disturbances

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Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1308))

Abstract

Sleep disorders have a high prevalence both in the general population and especially in specific populations such older adults and oncologic patients. Impacting on quality of life, they often translate in drug prescription, with consequent increased risk of drug-drug interactions and adverse drug reactions. In the last years several products derived from plants have been developed with the aim of treating insomnia with lower risk of side effects. Despite several studies have been performed with this aim, the available evidence is inconclusive, and reviews summarizing the most recent evidences on the effectiveness of plant-derived products in treating insomnia are lacking.

This narrative review aims at summarizing the evidences of the mechanism of action, effectiveness and safety of the most commonly used plant-derived products for the treatment of sleep disorders (Valerian, Lemon balm, Passionflower, Chamomile, Hops, and Jujube).

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References

  1. Ohayon MM (2011) Epidemiological overview of sleep disorders in the general population. Sleep Med Res 2(1):1–9

    Article  Google Scholar 

  2. Katz DA, McHorney CA (1998) Clinical correlates of insomnia in patients with chronic illness. Arch Intern Med 158(10):1099–1107

    Article  CAS  PubMed  Google Scholar 

  3. Dujardin S, Pijpers A, Pevernagie D (2018) Prescription drugs used in insomnia. Sleep Med Clin 13(2):169–182

    Article  PubMed  Google Scholar 

  4. Romero K, Goparaju B, Russo K, Westover MB, Bianchi MT (2017) Alternative remedies for insomnia: a proposed method for personalized therapeutic trials. Nat Sci Sleep 9:97–108

    Article  PubMed  PubMed Central  Google Scholar 

  5. Sateia MJ, Buysse DJ, Krystal AD, Neubauer DN, Heald JL (2017) Clinical practice guideline for the pharmacologic treatment of chronic insomnia in adults: an American Academy of Sleep Medicine Clinical Practice Guideline. J Clin Sleep Med 13(2):307–349

    Article  PubMed  PubMed Central  Google Scholar 

  6. Riemann D, Baglioni C, Bassetti C, Bjorvatn B, Dolenc Groselj L, Ellis JG et al (2017) European guideline for the diagnosis and treatment of insomnia. J Sleep Res 26(6):675–700

    Article  PubMed  Google Scholar 

  7. Sarris J, Byrne GJ (2011) A systematic review of insomnia and complementary medicine. Sleep Med Rev 15(2):99–106

    Article  PubMed  Google Scholar 

  8. Pearson NJ, Johnson LL, Nahin RL (2006) Insomnia, trouble sleeping, and complementary and alternative medicine: analysis of the 2002 national health interview survey data. Arch Intern Med 166(16):1775–1782

    Article  PubMed  Google Scholar 

  9. Ross SM (2014) Psychophytomedicine: an overview of clinical efficacy and phytopharmacology for treatment of depression, anxiety and insomnia. Holist Nurs Pract 28(4):275–280

    Article  PubMed  Google Scholar 

  10. Anonymous (2018) Valerianae radix [Internet]. European Medicines Agency. [cited 2019 Dec 10]. Available from: https://www.ema.europa.eu/en/medicines/herbal/valerianae-radix

  11. Benke D, Barberis A, Kopp S, Altmann K-H, Schubiger M, Vogt KE et al (2009) GABA A receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts. Neuropharmacology 56(1):174–181

    Article  CAS  PubMed  Google Scholar 

  12. Dietz BM, Mahady GB, Pauli GF, Farnsworth NR (2005) Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Brain Res Mol Brain Res 138(2):191–197

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Anderson GD, Elmer GW, Taibi DM, Vitiello MV, Kantor E, Kalhorn TF et al (2010) Pharmacokinetics of valerenic acid after single and multiple doses of valerian in older women. Phytother Res 24(10):1442–1446

    Article  CAS  PubMed  Google Scholar 

  14. Choi H-S, Ko BS, Kim HD, Hong K-B, Suh HJ (2017) Effect of Valerian/Hop mixture on sleep-related behaviors in Drosophila melanogaster. Biol Pharm Bull 40(7):1101–1110

    Article  CAS  PubMed  Google Scholar 

  15. Choi H-S, Hong K-B, Han SH, Suh HJ (2018) Valerian/Cascade mixture promotes sleep by increasing non-rapid eye movement (NREM) in rodent model. Biomed Pharmacother 99:913–920

    Article  PubMed  Google Scholar 

  16. Sahu S, Ray K, Yogendra Kumar MS, Gupta S, Kauser H, Kumar S et al (2012) Valeriana wallichii root extract improves sleep quality and modulates brain monoamine level in rats. Phytomedicine 19(10):924–929

    Article  PubMed  Google Scholar 

  17. Xu K, Lin Y, Zhang R, Lan M, Chen C, Li S et al (2015) Evaluation of safety of iridoids rich fraction from Valeriana jatamansi Jones: acute and sub-chronic toxicity study in mice and rats. J Ethnopharmacol 172:386–394

    Article  CAS  PubMed  Google Scholar 

  18. Kim J, Lee SL, Kang I, Song YA, Ma J, Hong YS et al (2018) Natural products from single plants as sleep aids: a systematic review. J Med Food 21(5):433–444

    Article  PubMed  Google Scholar 

  19. Dey A, Dey A (2013) Phytotherapy against insomnia: extravagant claims or an alternative medicine? Pak J Biol Sci 16(3):148–150

    Article  PubMed  Google Scholar 

  20. Regestein QR (2011) Is there anything special about valerian? Menopause 18(9):937–939

    Article  PubMed  Google Scholar 

  21. Salter S, Brownie S (2010) Treating primary insomnia – the efficacy of valerian and hops. Aust Fam Physician 39(6):433–437

    PubMed  Google Scholar 

  22. Fernández-San-Martín MI, Masa-Font R, Palacios-Soler L, Sancho-Gómez P, Calbó-Caldentey C, Flores-Mateo G (2010) Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials. Sleep Med 11(6):505–511

    Article  PubMed  Google Scholar 

  23. Taavoni S, Ekbatani N, Kashaniyan M, Haghani H (2011) Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial. Menopause 18(9):951–955

    Article  PubMed  Google Scholar 

  24. Barton DL, Atherton PJ, Bauer BA, Moore DF, Mattar BI, Lavasseur BI et al (2011) The use of Valeriana officinalis (Valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study (NCCTG Trial, N01C5). J Support Oncol 9(1):24–31

    Article  PubMed  PubMed Central  Google Scholar 

  25. Cuellar NG, Ratcliffe SJ (2009) Does valerian improve sleepiness and symptom severity in people with restless legs syndrome? Altern Ther Health Med 15(2):22–28

    PubMed  Google Scholar 

  26. Maroo N, Hazra A, Das T (2013) Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. Indian J Pharm 45(1):34–39

    Article  Google Scholar 

  27. Thomas K, Canedo J, Perry PJ, Doroudgar S, Lopes I, Chuang HM et al (2016) Effects of valerian on subjective sedation, field sobriety testing and driving simulator performance. Accid Anal Prev 92:240–244

    Article  PubMed  Google Scholar 

  28. Schutte-Rodin S, Broch L, Buysse D, Dorsey C, Sateia M (2008) Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med 4(5):487–504

    Article  PubMed  PubMed Central  Google Scholar 

  29. Mann C, Staba EJ (1986) The chemistry, pharmacology, and commercial formulations of chamomile. Herbs, spices, and medicinal plants : recent advances in botany, horticulture, and pharmacology (USA) [Internet]. [cited 2019 Dec 10]; Available from: http://agris.fao.org/agris-search/search.do?recordID=US8700832

  30. Mulinacci N, Romani A, Pinelli P, Vincieri FF, Prucher D (2000) Characterization ofMatricaria recutita L. Flower extracts by HPLC-MS and HPLC-DAD analysis. Chromatographia 51(5):301–307

    Article  CAS  Google Scholar 

  31. Barene I, Daberte I, Zvirgzdina L, Iriste V (2003) The complex technology on products of German chamomile. Medicina (Kaunas) 39(Suppl 2):127–131

    Google Scholar 

  32. Loggia RD, Traversa U, Scarcia V, Tubaro A (1982) Depressive effects of Chamomilla recutita (L.) Rausch, tubular flowers, on central nervous system in mice. Pharmacol Res Commun 14(2):153–162

    Article  CAS  PubMed  Google Scholar 

  33. Viola H, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F et al (1995) Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 61(3):213–216

    Article  CAS  PubMed  Google Scholar 

  34. Salgueiro JB, Ardenghi P, Dias M, Ferreira MB, Izquierdo I, Medina JH (1997) Anxiolytic natural and synthetic flavonoid ligands of the central benzodiazepine receptor have no effect on memory tasks in rats. Pharmacol Biochem Behav 58(4):887–891

    Article  CAS  PubMed  Google Scholar 

  35. Yamada K, Miura T, Mimaki Y, Sashida Y (1996) Effect of inhalation of chamomile oil vapour on plasma ACTH level in ovariectomized-rat under restriction stress. Biol Pharm Bull 19(9):1244–1246

    Article  CAS  PubMed  Google Scholar 

  36. Adib-Hajbaghery M, Mousavi SN (2017) The effects of chamomile extract on sleep quality among elderly people: a clinical trial. Complement Ther Med 35:109–114

    Article  PubMed  Google Scholar 

  37. Abdullahzadeh M, Matourypour P, Naji SA (2017) Investigation effect of oral chamomilla on sleep quality in elderly people in Isfahan: a randomized control trial. J Educ Health Promot 6:53

    PubMed  PubMed Central  Google Scholar 

  38. Chang S-M, Chen C-H (2016) Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial. J Adv Nurs 72(2):306–315

    Article  PubMed  Google Scholar 

  39. Zick SM, Wright BD, Sen A, Arnedt JT (2011) Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC Complement Altern Med 11:78

    Article  PubMed  PubMed Central  Google Scholar 

  40. Hieu TH, Dibas M, Surya Dila KA, Sherif NA, Hashmi MU, Mahmoud M et al (2019) Therapeutic efficacy and safety of chamomile for state anxiety, generalized anxiety disorder, insomnia, and sleep quality: a systematic review and meta-analysis of randomized trials and quasi-randomized trials. Phytother Res 33(6):1604–1615

    Article  PubMed  Google Scholar 

  41. Cornu C, Remontet L, Noel-Baron F, Nicolas A, Feugier-Favier N, Roy P et al (2010) A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial. BMC Complement Altern Med 10:29

    Article  PubMed  PubMed Central  Google Scholar 

  42. Shou CH, Wang J, Zheng XX, Guo DW (2001) Inhibitory effect of jujuboside A on penicillin sodium induced hyperactivity in rat hippocampal CA1 area in vitro. Acta Pharmacol Sin 22(11):986–990

    CAS  PubMed  Google Scholar 

  43. Zhang M, Ning G, Shou C, Lu Y, Hong D, Zheng X (2003) Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus. Planta Med 69(8):692–695

    Article  CAS  PubMed  Google Scholar 

  44. Lu Y-J, Zhou J, Zhang S-M, Zhang H-Y, Zheng X-X (2005) Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat. J Zhejiang Univ Sci B 6(4):265–271

    Article  PubMed  PubMed Central  Google Scholar 

  45. Wang C, You Z, Xia Q, Xiong T, Xia Y, Yao D (2007) Upregulation of Mark3 and Rpgrip1 mRNA expression by jujuboside A in mouse hippocampus. Acta Pharmacol Sin 28(3):334–338

    Article  PubMed  Google Scholar 

  46. Chen CY-C (2009) Chemoinformatics and pharmacoinformatics approach for exploring the GABA-A agonist from Chinese herb suanzaoren. J Taiwan Inst Chem Eng 40(1):36–47

    Article  CAS  Google Scholar 

  47. You Z, Xia Q, Liang F, Tang Y, Xu C, Huang J et al (2010) Effects on the expression of GABAA receptor subunits by jujuboside A treatment in rat hippocampal neurons. J Ethnopharmacol 128(2):419–423

    Article  CAS  PubMed  Google Scholar 

  48. Hu L-L, Zhang X, Liu W-J, Li M, Zhang Y-H (2015) Suan zao ren tang in combination with zhi zi chi tang as a treatment protocol for insomniacs with anxiety: a randomized parallel-controlled trial. Evid Based Complement Alternat Med 2015:913252

    Article  PubMed  PubMed Central  Google Scholar 

  49. Xie C, Gu Y, Wang W-W, Lu L, Fu D, Liu A et al (2013) Efficacy and safety of Suanzaoren decoction for primary insomnia: a systematic review of randomized controlled trials. BMC Complement Altern Med 13:18

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Miraj S, Rafieian-Kopaei N, Kiani S (2017) Melissa officinalis L: a review study with an antioxidant prospective. J Evid Based Complement Altern Med 22(3):385–394

    Article  CAS  Google Scholar 

  51. Haybar H, Javid AZ, Haghighizadeh MH, Valizadeh E, Mohaghegh SM, Mohammadzadeh A (2018) The effects of Melissa officinalis supplementation on depression, anxiety, stress, and sleep disorder in patients with chronic stable angina. Clin Nutr ESPEN 26:47–52

    Article  PubMed  Google Scholar 

  52. Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SG (2011) Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutr Metab 4(3):211–218

    Article  Google Scholar 

  53. Appel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss G (2011) Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res 25(6):838–843

    Article  CAS  PubMed  Google Scholar 

  54. Ngan A, Conduit R (2011) A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Phytother Res 25(8):1153–1159

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Area di Geriatria, Università Campus Bio-Medico di Roma, Roma, Italy

    Diana Lelli, Livio Cortese & Claudio Pedone

Authors
  1. Diana Lelli
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  2. Livio Cortese
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  3. Claudio Pedone
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Corresponding author

Correspondence to Diana Lelli .

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Editors and Affiliations

  1. Department of Biological Sciences, University of Limerick, Limerick, Ireland

    George E. Barreto

  2. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

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Lelli, D., Cortese, L., Pedone, C. (2021). Use of Plant-Derived Natural Products in Sleep Disturbances. In: Barreto, G.E., Sahebkar, A. (eds) Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Advances in Experimental Medicine and Biology, vol 1308. Springer, Cham. https://doi.org/10.1007/978-3-030-64872-5_15

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