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Effect of Curcumin on Severity of Functional Dyspepsia: a Triple Blinded Clinical Trial

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 1308)

Abstract

Background

Functional dyspepsia is the main cause of upper abdominal discomfort affecting 5–10% of the world population. Despite various therapeutic approaches, up to 50% of patients with functional dyspepsia seek alternative treatments. In the present study we evaluated the effect of curcumin supplementation along with famotidine therapy on severity of functional dyspepsia. A total of 75 patients with functional dyspepsia according to Rome III criteria were allocated into intervention (N = 39) or control (N = 36) groups. The intervention group was treated with a combination of 500 mg curcumin and 40 mg famotidine daily for 1 month. The control group received placebo and 40 mg famotidine. Severity of dyspepsia symptoms was determined using the Hong Kong questionnaire at baseline, after the 1 month treatment and after a 1 month follow-up. The presence of H. pylori antigens in the stool samples was also investigated in all subjects. No significant difference was observed between intervention and control groups in biochemical indices, severity of dyspepsia and rate of H. pylori infection. A significant decrease was observed in severity of dyspepsia (p < 0.001) and rate of H. pylori infection (p = 0.004) immediately after the treatment and follow-up in the curcumin intervention group. This study indicated that curcumin therapy could be a favorable supplementation in the symptom management of functional dyspepsia. Moreover, curcumin could help efficient eradication of H. pylori in these patients.

Keywords

  • Functional dyspepsia
  • Curcumin
  • H. pylori

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Fig. 10.1
Fig. 10.2

References

  1. Talley NJ, Ford AC (2015) Functional dyspepsia. N Engl J Med 373(19):1853–1863

    CAS  CrossRef  Google Scholar 

  2. Imthon AK, Moeller ME, Drewes AM, Juel J, Aziz Q (2015) Functional gastroduodenal disorders. Hamdan Med J 212(2374):1–11

    Google Scholar 

  3. Moayyedi P, Soo S, Deeks J, Delaney B, Innes M, Forman D (2006) Pharmacological interventions for non-ulcer dyspepsia. Cochrane Database Syst Rev 4:CD001960. https://doi.org/10.1002/14651858.CD001960.pub3

    CrossRef  Google Scholar 

  4. Drossman DA, Dumitrascu DL (2006) Rome III: new standard for functional gastrointestinal disorders. J Gastrointestin Liver Dis 15(3):237–241

    PubMed  Google Scholar 

  5. Moayyedi P, Soo S, Deeks J, Delaney B, Harris A, Innes M et al (2005) Eradication of Helicobacter pylori for non-ulcer dyspepsia. Cochrane Database Syst Rev 1:CD002096. https://doi.org/10.1002/14651858.CD002096.pub2

    CrossRef  Google Scholar 

  6. Van Kerkhoven LA, Laheij RJ, Aparicio N, De Boer WA, Van Den Hazel S, Tan AC et al (2008) Effect of the antidepressant venlafaxine in functional dyspepsia: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 6(7):746–752

    CrossRef  Google Scholar 

  7. Ly HG, Carbone F, Holvoet L, Bisschops R, Caenepeel P, Arts J et al (2013) 161 mirtazapine improves early satiation, nutrient intake, weight recovery and quality of life in functional dyspepsia with weight loss: a double-blind, randomized, Placebo-Controlled Pilot Study. American Gastroenterological Association | American ...www.gastro.org

  8. The American Gastroenterological Association (AGA) abstract. Gastroenterology 144(5):S–37

    Google Scholar 

  9. Talley NJ, Locke GR, Saito YA, Almazar AE, Bouras EP, Howden CW et al (2015) Effect of amitriptyline and escitalopram on functional dyspepsia: a multicenter, randomized controlled study. Gastroenterology 149(2):340–349.e2

    CAS  CrossRef  Google Scholar 

  10. Tan VP, Cheung TK, Wong WM, Pang R, Wong BC (2012) Treatment of functional dyspepsia with sertraline: a double-blind randomized placebo-controlled pilot study. World J Gastroenterol 18(42):6127–6133

    CAS  CrossRef  Google Scholar 

  11. Bortolotti M, Coccia G, Grossi G, Miglioli M (2002) The treatment of functional dyspepsia with red pepper. Aliment Pharmacol Ther 16(6):1075–1082

    CAS  CrossRef  Google Scholar 

  12. Pilichiewicz AN, Horowitz M, Russo A, Maddox AF, Jones KL, Schemann M et al (2007) Effects of Iberogast on proximal gastric volume, antropyloroduodenal motility and gastric emptying in healthy men. Am J Gastroenterol 102(6):1276–1283

    CAS  CrossRef  Google Scholar 

  13. Lahner E, Bellentani S, Bastiani RD, Tosetti C, Cicala M, Esposito G et al (2013) A survey of pharmacological and nonpharmacological treatment of functional gastrointestinal disorders. United European Gastroenterol J 1(5):385–393

    CrossRef  Google Scholar 

  14. Mollazadeh H, Cicero AFG, Blesso CN, Pirro M, Majeed M et al (2019) Immune modulation by curcumin: the role of interleukin-10. Crit Rev Food Sci Nutr 59(1):89–101

    CAS  CrossRef  Google Scholar 

  15. Soleimani V, Sahebkar A, Hosseinzadeh H (2018) Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phytother Res 32(6):985–995

    Google Scholar 

  16. Teymouri M, Pirro M, Johnston TP, Sahebkar A (2017) Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: a review of chemistry, cellular, molecular, and preclinical features. Biofactors 43(3):331–346

    Google Scholar 

  17. Momtazi AA, Derosa G, Maffioli P, Banach M, Sahebkar A (2016) Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases. Mol Diagn Ther 20(4):335–345

    Google Scholar 

  18. Ghandadi M, Sahebkar A (2017) Curcumin: An effective inhibitor of interleukin-6. Curr Pharm Des 23(6):921–931

    Google Scholar 

  19. Panahi Y, Khalili N, Sahebi E, Namazi S, Simental-Mendía LE, Majeed M, Sahebkar A. Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial. Drug Res (Stuttg). 2018 Jul;68(7):403-409. https://doi.org/10.1055/s-0044-101752.

  20. Panahi Y, Ahmadi Y, Teymouri M, Johnston TP, Sahebkar A (2018) Curcumin as a potential candidate for treating hyperlipidemia: a review of cellular and metabolic mechanisms. J Cell Physiol 233(1):141−152

    Google Scholar 

  21. Panahi Y, Khalili N, Sahebi E, Namazi S, Simental-Mendía LE, Majeed M, et al (2018) Effects of curcuminoids plus piperine on glycemic, hepatic and inflammatory biomarkers in patients with type 2 diabetes mellitus: a randomized double-blind placebo-controlled trial. Drug Res (Stuttg) 68(7):403−409

    Google Scholar 

  22. Di Mario F, Cavallaro LG, Nouvenne A, Stefani N, Cavestro GM, Iori V et al (2007) A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure? Helicobacter 12(3):238–243

    CrossRef  Google Scholar 

  23. Khonche A, Biglarian O, Panahi Y, Valizadegan G, Soflaei S, Ghamarchehreh M et al (2016) Adjunctive therapy with curcumin for peptic ulcer: a randomized controlled trial. Drug Res 66(08):444–448

    CAS  CrossRef  Google Scholar 

  24. Chemnitzer O, Götzel K, Maurer L, Dietrich A, Eichfeld U, Lyros O et al (2017) Response to TNF-α is increasing along with the progression in Barrett’s esophagus. Dig Dis Sci 62(12):3391–3401

    CAS  CrossRef  Google Scholar 

  25. Czekaj R, Majka J, Ptak-Belowska A, Szlachcic A, Targosz A, Magierowska K et al (2016) Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. J Physiol Pharmacol 67(2):261–275

    CAS  PubMed  Google Scholar 

  26. Haider S, Naqvi F, Tabassum S, Saleem S, Batool Z, Sadir S et al (2013) Preventive effects of curcumin against drug-and starvation-induced gastric erosions in rats. Sci Pharm 81(2):549–558

    CAS  CrossRef  Google Scholar 

  27. He P, Zhou R, Hu G, Liu Z, Jin Y, Yang G et al (2015) Curcumin-induced histone acetylation inhibition improves stress-induced gastric ulcer disease in rats. Mol Med Rep 11(3):1911–1916

    CAS  CrossRef  Google Scholar 

  28. Kerdsakundee N, Mahattanadul S, Wiwattanapatapee R (2015) Development and evaluation of gastroretentive raft forming systems incorporating curcumin-Eudragit® EPO solid dispersions for gastric ulcer treatment. Eur J Pharm Biopharm 94:513–520

    CAS  CrossRef  Google Scholar 

  29. Liang Z, Wu R, Xie W, Geng H, Zhao L, Xie C et al (2015) Curcumin suppresses MAPK pathways to reverse tobacco smoke-induced gastric epithelial–mesenchymal transition in mice. Phytother Res 29(10):1665–1671

    CAS  CrossRef  Google Scholar 

  30. Martin RC, Locatelli E, Li Y, Zhang W, Li S, Monaco I et al (2015) Gold nanorods and curcumin-loaded nanomicelles for efficient in vivo photothermal therapy of Barrett’s esophagus. Nanomedicine 10(11):1723–1733

    CAS  CrossRef  Google Scholar 

  31. Panahi Y, Ghanei M, Hajhashemi A, Sahebkar A (2016) Effects of curcuminoids-piperine combination on systemic oxidative stress, clinical symptoms and quality of life in subjects with chronic pulmonary complications due to sulfur mustard: a randomized controlled trial. J Diet Suppl 13(1):93–105

    CAS  CrossRef  Google Scholar 

  32. Santos A, Lopes T, Oleastro M, Gato I, Floch P, Benejat L et al (2015) Curcumin inhibits gastric inflammation induced by Helicobacter pylori infection in a mouse model. Nutrients 7(1):306–320

    CrossRef  Google Scholar 

  33. Panahi Y, Kianpour P, Mohtashami R, Soflaei SS, Sahebkar A (2019) Efficacy of phospholipidated curcumin in nonalcoholic fatty liver disease: a clinical study. J Asian Nat Prod Res 21(8):798–805

    CAS  CrossRef  Google Scholar 

  34. Hu WH, Lam KF, Wong YH, Lam CL, WM HU, Lai KC et al (2002) The Hong Kong index of dyspepsia: a validated symptom severity questionnaire for patients with dyspepsia. J Gastroenterol Hepatol 17(5):545–551

    Google Scholar 

  35. Sarkar A, De R, Mukhopadhyay AK (2016) Curcumin as a potential therapeutic candidate for Helicobacter pylori associated diseases. World J Gastroenterol 22(9):2736–2748

    Google Scholar 

  36. De R, Kundu P, Swarnakar S, Ramamurthy T, Chowdhury A, Nair GB et al (2009) Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrob Agents Chemother 53(4):1592–1597

    Google Scholar 

  37. Sintara K, Thong-Ngam D, Patumraj S, Klaikeaw N, Chatsuwan T (2010) Curcumin suppresses gastric NF-kappaB activation and macromolecular leakage in Helicobacter pylori-infected rats. World J Gastroenterol 16(32):4039–4046

    Google Scholar 

  38. Foryst-Ludwig A, Neumann M, Schneider-Brachert W, Naumann M (2004) Curcumin blocks NF-κB and the motogenic response in Helicobacter pylori-infected epithelial cells. Biochem Biophys Res Commun 316(4):1065–1072

    Google Scholar 

  39. Kundu P, De R, Pal I, Mukhopadhyay AK, Saha DR, Swarnakar S (2011) Curcumin alleviates matrix metalloproteinase-3 and-9 activities during eradication of Helicobacter pylori infection in cultured cells and mice. PLoS One 6(1):e16306. https://doi.org/10.1371/journal.pone.0016306

  40. Vetvicka V, Vetvickova J, Fernandez-Botran R (2016) Effects of curcumin on Helicobacter pylori infection. Ann Transl Med 4(24):479. https://doi.org/10.21037/atm.2016.12.52

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Conflict of Interest

Muhammed Majeed is the founder of Sabinsa Corp. and Sami Labs Ltd. The other authors declare no competing interests.

Funding

This study was supported by the Research Council at the Baqiyatallah University of Medical Sciences.

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Correspondence to Ashraf Karbasi or Amirhossein Sahebkar .

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Panahi, Y. et al. (2021). Effect of Curcumin on Severity of Functional Dyspepsia: a Triple Blinded Clinical Trial. In: Barreto, G.E., Sahebkar, A. (eds) Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Advances in Experimental Medicine and Biology, vol 1308. Springer, Cham. https://doi.org/10.1007/978-3-030-64872-5_10

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