Abstract
Skin cancer is the most common cancer in the United States. The malignancy occurs less frequently in individuals with skin of color, yet has a higher mortality rate than other racial groups due to misdiagnoses, inaccessibility to skin cancer screenings, and lack of skin cancer awareness. Skin cancer can present atypically in individuals with skin of color, often resulting in misidentification, a delayed diagnosis, and an advanced tumor. In skin of color, basal cell carcinoma is associated with UVR and presents as a pigmented nodule with pearly borders. Squamous cell carcinoma commonly arises from chronic inflammation, appearing as a pigmented papule or nodule on non-sun-exposed areas such as the lower extremities and anogenital region. Malignant melanoma is the deadliest form, occurring in abnormal anatomical sites including the nail beds, palms and soles, and mucosal membranes. Understanding the characteristic features for skin cancers in skin of color and increasing awareness of the malignancy is necessary to improve the outcome for this population and allow for prompt diagnoses and effective treatment.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Guy GP, et al. Vital signs: melanoma incidence and mortality trends and projections – United States, 1982–2030. MMWR. 2015;64(21):591–6.
Stern RS. Prevalence of a history of skin cancer in 2007: results of an incidence-based model. Arch Dermatol. 2010;146(3):279–82.
Skin cancer. 2018 [cited 2018 December 21]; Available from: https://www.aad.org/media/stats/conditions/skin-cancer.
Benjamin CL, Ananthaswamy HN. p53 and the pathogenesis of skin cancer. Toxicol Appl Pharmacol. 2007;224(3):241–8.
Narayanan DL, Saladi RN, Fox JL. Ultraviolet radiation and skin cancer. Int J Dermatol. 2010;49(9):978–86.
Prevent skin cancer. 2018 [cited 2018 December 21]; Available from: https://www.aad.org/public/spot-skin-cancer/learn-about-skin-cancer/prevent.
Surveillance, Epidemiology, and End Results (SEER) Program. 2018.
Avilés-Izquierdo JA, et al. Who detects melanoma? Impact of detection patterns on characteristics and prognosis of patients with melanoma. J Am Acad Dermatol. 2016;75(5):967–74.
What to look for: ABCDEs of melanoma. 2018 [cited 2018 December 22].
Rotte A, Bhandaru M. Melanoma—diagnosis, subtypes and AJCC stages. In: Immunotherapy of melanoma, vol. 21-47. Cham: Springer International Publishing; 2016.
Gershenwald, J.E. and R.A.J.A.o.S.O. Scolyer, Melanoma Staging: American Joint Committee on Cancer (AJCC) 8th Edition and Beyond. 2018. 25(8): p. 2105–2110.
Surveillance, Epidemiology, and End Results (SEER) Program 2018, National Cancer Institute: Bethesda
Singh P, Kim HJ, Schwartz RA. Superficial spreading melanoma: an analysis of 97 702 cases using the SEER database. Melanoma Res. 2016;26(4):395–400.
Types of Melanoma. 2018 [cited 2018 December 22, 2018].
Garbe C, Bauer J. In: Bolognia JL, Schaffer JV, Cerroni L, editors. Melanoma. 4th ed: Elsevier; 2018.
Kibbi N, Kluger H, Choi JN. Melanoma: clinical presentations. In: Kaufman HL, Mehnert JM, editors. Melanoma. Cham: Springer International Publishing; 2016. p. 107–29.
Smoller BR. Histologic criteria for diagnosing primary cutaneous malignant melanoma. Mod Pathol. 2006;19:S34–40.
Dhomen N, Marais R. New insight into BRAF mutations in cancer. Curr Opin Genet Dev. 2007;17(1):31–9.
Menzies SW, et al. Dermoscopic evaluation of nodular melanoma. JAMA Dermatol. 2013;149(6):699–709.
Brinster NK, et al. Melanoma. In: Brinster NK, et al., editors. Dermatopathology: high-yield pathology. Philadelphia: Elsevier; 2011. p. 355–63.
Charifa A, Chen CSJ. Cancer, melanoma, lentigo maligna: StatPearls; 2018. [cited 2018 December 23, 2018].
Weinstock MA, Sober AJ. The risk of progression of lentigo maligna to lentigo maligna melanoma. Br J Dermatol. 1987;116(3):303–10.
Cohen LM. Lentigo maligna and lentigo maligna melanoma. J Am Acad Dermatol. 1995;33(6):923–36.
Elston DM. Melanocytic neoplasms. In: Elston DM, Ferringer T, editors. Dermatopathology: Elsevier. p. 101–31.
Metzger S, et al. Extent and consequences of physician delay in the diagnosis of acral melanoma. Melanoma Res. 1998;8(2):181–6.
Bradford PT, et al. Acral lentiginous melanoma: incidence and survival patterns in the United States, 1986-2005. Arch Dermatol. 2009;145(4):427–34.
Chu DH. Structure and function of the skin. In: Goldman L, Schafer AL, editors. Goldman-cecil medicine. Philadelphia: Elsevier; 2016. p. 2632–7.
Basal cell carcinoma. 2018 [cited 2018 December 21]; Available from: https://www.skincancer.org/skin-cancer-information/basal-cell-carcinoma.
Marzuka AG, Book SE. Basal cell carcinoma: pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management. Yale J Biol Med. 2015;88(2):167–79.
Ortel B, Bolotin D. Cancer of the skin. In: Kellerman RD, Bope ET, editors. Conn’s current therapy 2018. Philadelphia, PA: Elsevier; 2018.
SEER training modules, layers of the skin. 2018 [cited 2018 December 22]; Available from: https://training.seer.cancer.gov/melanoma/anatomy/layers.html.
Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med. 2001;344(13):975–83.
Bradford PT. Skin cancer in skin of color. Dermatol Nurs. 2009;21(4):170–206.
Reha J, Katz SC. Dermatofibrosarcoma protuberans. Surg Clin N Am. 2016;96(5):1031–46.
Thway K, et al. Dermatofibrosarcoma protuberans: pathology, genetics, and potential therapeutic strategies. Ann Diagn Pathol. 2016;25:64–71.
Pulitzer M. Merkel cell carcinoma. Surg Pathol Clin. 2017;10(2):399–408.
Cassler NM, et al. Merkel cell carcinoma therapeutic update. Curr Treat Options Oncol. 2016;17(7):36.
Gandhi SA, Kampp J. Skin cancer epidemiology, detection, and management. Med Clin. 2015;99(6):1323–35.
Swetter SM, et al. Guidelines of care for the management of primary cutaneous melanoma. J Am Acad Dermatol. 2019;80(1):208–50.
Network, N.C.C. Melanoma. 2018 April 30, 2019]; Available from: https://www.nccn.org/patients/guidelines/melanoma/files/assets/common/downloads/files/melanoma.pdf.
Shriner DL, et al. Mohs micrographic surgery. J Am Acad Dermatol. 1998;39(1):79–97.
Divine J, et al. A comprehensive guide to the surgical management of nonmelanoma skin cancer. Curr Probl Cancer. 2015;39(4):216–25.
Bichakjian C, et al. Guidelines of care for the management of basal cell carcinoma. J Am Acad Dermatol. 2018;78(3):540–59.
Alam M, et al. Guidelines of care for the management of cutaneous squamous cell carcinoma. J Am Acad Dermatol. 2018;78(3):560–78.
Higgins S, et al. Review of nonmelanoma skin Cancer in African Americans, hispanics, and asians. Dermatol Surg. 2018;44(7):903–10.
Gloster HM, Neal K. Skin cancer in skin of color. J Am Acad Dermatol. 2006;55(5):741–60.
Morrison BF. Risk factors and prevalence of penile cancer. West Indian Med J. 2014;63(6):559–60.
Wich LG, et al. Impact of socioeconomic status and sociodemographic factors on melanoma presentation among ethnic minorities. J Community Health. 2011;36(3):461–8.
Jacobsen AA, et al. Defining the need for skin cancer prevention education in uninsured, minority, and immigrant communities. JAMA Dermatol. 2016;152(12):1342–7.
Marneros AG, et al. Clinical genetics of familial keloids. Arch Dermatol. 2001;137(11):1429–34.
Buster KJ, et al. Skin cancer risk perceptions: a comparison across ethnicity, age, education, gender, and income. J Am Acad Dermatol. 2012;66(5):771–9.
Korta DZ, Saggar V, Wu TP, Sanchez M. Racial differences in skin cancer awareness and surveillance practices at a public hospital dermatology clinic. J Am Acad Dermatol. 2013;70(2):312–7.
Pipitone M, et al. Skin cancer awareness in suburban employees: a Hispanic perspective. J Am Acad Dermatol. 2002;47(1):118–23.
Teramoto Y, Martinez-Said H, Guo J, Garbe C. (2019) Acral Lentiginous Melanoma. In: Balch C. et al. (eds) Cutaneous Melanoma. Springer, Cham. https://doi-org.libproxy2.usc.edu/10.1007/978-3-319-46029-1_67-1.
Jackson BA, Jackson BA. (2013) Skin Cancers in Skin of Color. In: Alexis A, Barbosa V. (eds) Skin of Color. Springer, New York, NY. https://doi-org.libproxy2.usc.edu/10.1007/978-0-387-84929-4_11.
Al-Haseni A, Sahni D. (2017) Skin Cancer. In: Vashi N, Maibach H. (eds) Dermatoanthropology of Ethnic Skin and Hair. Springer, Cham. https://doi-org.libproxy2.usc.edu/10.1007/978-3-319-53961-4_16.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Manier, K.K., Maibach, H.I. (2021). Skin Cancer Knowledge, Awareness, and Perception. In: Li, B.S., Maibach, H.I. (eds) Ethnic Skin and Hair and Other Cultural Considerations. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-64830-5_5
Download citation
DOI: https://doi.org/10.1007/978-3-030-64830-5_5
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-64829-9
Online ISBN: 978-3-030-64830-5
eBook Packages: MedicineMedicine (R0)