Skip to main content

Management of Pigmentary Disorders

  • Chapter
  • First Online:
Ethnic Skin and Hair and Other Cultural Considerations

Part of the book series: Updates in Clinical Dermatology ((UCD))

  • 429 Accesses

Abstract

Disorders of pigmentation, both hyper- and hypopigmentation, are common entities encountered in dermatology. They can be caused by a variety of underlying systemic diseases and infections, as well as present as primary cutaneous disorders and secondary to injury or trauma. Contributing factors leading to both types of pigmentary alterations include both an effect on melanocytes and the activity and rate of melanin production. The most common disorders of hypopigmentation that will be discussed in this chapter include post-inflammatory hypopigmentation, hypopigmented mycosis fungoides, pityriasis alba, tinea versicolor, progressive macular hypomelanosis, idiopathic guttate hypomelanosis, and vitiligo. Hyperpigmentation disorders to be discussed include post-inflammatory hyperpigmentation, melasma, lichen planus pigmentosus, erythema dyschromicum perstans, and drug-induced and metabolic conditions causing hyperpigmentation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Vachiramon V, Thadanipon K. Postinflammatory hypopigmentation. Clin Exp Dermatol. 2011;36:708–14.

    Article  CAS  PubMed  Google Scholar 

  2. Verma S, Patterson JW, Derdeyn AS, et al. Hypopigmented macules in an Indian man. Arch Dermatol. 2006;142:1643–8.

    Article  PubMed  Google Scholar 

  3. Rowley MJ, Nesbitt LT Jr, Carrington PR, Espinoza CG. Hypopigmented macules in acantholytic disorders. Int J Dermatol. 1995;34:390–2.

    Article  CAS  PubMed  Google Scholar 

  4. Yang CC, Lee JY, Won TW. Depigmented extramammary Paget’s disease. Br J Dermatol. 2004;151:1049–53.

    Article  PubMed  Google Scholar 

  5. Halder RM, Richards GM. Management of dyschromias in ethnic skin. Dermatol Ther. 2004;17:151–7.

    Article  PubMed  Google Scholar 

  6. High WA, Pandya AG. Pilot trial of 1% pimecrolimus cream in the treatment of seborrheic dermatitis in African American adults with associated hypopigmentation. J Am Acad Dermatol. 2006;54:1083–8.

    Article  PubMed  Google Scholar 

  7. Ruiz-Maldonado R, Orozco-Covarrubias ML. Postinflammatory hypopigmentation and hyperpigmentation. Semin Cutan Med Surg. 1997;16:36–43.

    Article  CAS  PubMed  Google Scholar 

  8. Grimes PE, Bhawan J, Ki J, et al. Laser resurfacing induced hypopigmentation: histologic alterations and repigmentation with topical photochemotherapy. Dermatol Surg. 2001;27:515–20.

    CAS  PubMed  Google Scholar 

  9. Alexiades-Armenakas MR, Bernstein LJ, Friedman PM, Geronemus RG. The safety and efficacy of the 308-nm excimer laser for pigment correction of hypopigmented scars and striae alba. Arch Dermatol. 2004;140:955–60.

    Article  PubMed  Google Scholar 

  10. Suvanprakorn P, Dee-Ananlap S, Pongsomboon C, Klaus SN. Melanocyte autologous grafting for treatment of leukoderma. J Am Acad Dermatol. 1985;13:968–74.

    Article  CAS  PubMed  Google Scholar 

  11. Bisherwal K, Singal A, Pandhi D, Sharma S. Hypopigmented mycosis fungoides: clinical, histological, and immunohistochemical remission induced by narrow-band ultraviolet B. Indian J Dermatol. 2017;62(2):203–6.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Fatemi N, Abtahi-Naeini B, Sadeghiyan H, Nilforoushzadeh MA, Najafian J, Pourazizi M. Mycosis fungoides in Iranian population: an epidemiological and clinicopathological study. J Skin Cancer. 2015;306543:1–6.

    Article  Google Scholar 

  13. Amorim G, Nieeyer-Corbellini J, Quintella DC, Cuzzi T, Ramos-e-Silva M. Hypopigmented mycosis fungoides: a 20-case retrospective series. Int J Dermatol. 2018;54:306–12.

    Article  Google Scholar 

  14. Yamashita T, Abbade LP, Marques ME, et al. Mycosis fungoides and Sezary syndrome: clinical, histopathological and immunohistochemical review and update. An Bras Dermatol. 2012;87:817–28.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Sanches JA Jr, Moricz CZM, Neto CF. Lymphoproliferative processes of the skin. Part 2- Cutaneous T-cell and NK-cell lymphomas. An Bras Dermatol. 2006;81:7–25.

    Google Scholar 

  16. Rodney IJ, Kindred C, Angra K, Qutub ON, Villanueva AR, Halder RM. Hypopigmented mycosis fungoides: a retrospective clinicohistopathologic study. J Eur Acad Dermatol Venereol: JEADV. 2017;31:808–14.

    Article  CAS  PubMed  Google Scholar 

  17. Tan EST, Tang MBY, Tan SH. Retrospective 5-year review of 131 patients with mycosis fungoides and sezary syndrome seen at the National Skin Centre, Singapore. Australas J Dermatol. 2006;47:248–52.

    Article  PubMed  Google Scholar 

  18. Furlan FC, Sanches JA. Hypopigmented mycosis fungoides: a review of its clinical features and pathophysiology. An Bras Dermatol. 2013;88:954–60.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Castano E, Glick S, Wolgast L, et al. Hypopigmented mycosis fungoides in childhood and adolescence: a long-term retrospective study. J Cutan Pathol. 2013;40:924–34.

    Article  PubMed  Google Scholar 

  20. Laws PM, Shear NH, Pope E. Childhood mycosis fungoides experience of 28 patients and response to phototherapy. Pediatr Dermatol. 2014;31:459–64.

    Article  PubMed  Google Scholar 

  21. Breathnach SM, McKee PH, Smith NP. Hypopigmented mycosis fungoides: report of five cases with ultrastructural observations. Br J Dermatol. 1982;106:643–9.

    Article  CAS  PubMed  Google Scholar 

  22. Boulos S, Vaid R, Aladily T, Ivan D, Talpur R, Duvic M. Clinical presentation, immunopathology, and treatment of juvenile-onset mycosis fungoides: a case series of 34 patients. J Am Acad Dermatol. 2014;71:1117–26.

    Article  PubMed  Google Scholar 

  23. Kanokungsee S, Rajatanavin N, Rutnin S, Vachiramon V. Efficacy of narrowband ultraviolet B twice weekly for hypopigmented mycosis fungoides in Asians. Clin Exp Dermatol. 2012;37:149–52.

    Article  Google Scholar 

  24. Carter J, Zug KA. Phototherapy for cutaneous T cell lymphoma: online survey and literature review. J Am Acad Dermatol. 2009;60:39–50.

    Article  PubMed  Google Scholar 

  25. Miazek N, Michalek I, Pawlowska-Kisiel M, Olszewska M, Rudnicka L. Pityriasis alba- common disease, enigmatic entity: up-to-date review of the literature. Pediatr Dermatol. 2015;32(6):786–91.

    Article  PubMed  Google Scholar 

  26. Jadotte YT, Jannige CK. Pityriasis alba revisited: perspectives on an enigmatic disorder of childhood. Cutis. 2011;87:66–72.

    PubMed  Google Scholar 

  27. Wells BT, Whyte HJ, Kierland RR. Pityriasis alba: a ten-year survey and review of the literature. Arch Dermatol. 1960;85:183–9.

    Article  Google Scholar 

  28. Givler DN, Givler A. Pityriasis, alba. StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2018.

    Google Scholar 

  29. Vargas-Ocampo F. Pityriasis alba: a histologic study. Int J Dermatol. 1993;32:870–3.

    Article  CAS  PubMed  Google Scholar 

  30. In SI, Yi SW, Kang HY, et al. Clinical and histopathological characteristics of pityriasis alba. Clin Exp Dermatol. 2009;34:591–7.

    Article  CAS  PubMed  Google Scholar 

  31. Kang HY, Choi YM. FK506 increases pigmentation and migration of human melanocytes. Br J Dermatol. 2006;155:1037–40.

    Article  CAS  PubMed  Google Scholar 

  32. Lin RL, Janniger CK. Pityriasis alba. Cutis. 2005;76:21–4.

    PubMed  Google Scholar 

  33. Al-Mutairi N, Hadad AA. Efficacy of 3058-nm xenon chloride excimer laser in pityriasis alba. Dermatol Surg. 2012;38:604–9.

    Article  CAS  PubMed  Google Scholar 

  34. Kallini J, Riaz F, Khachemoune A. Tinea versicolor in dark-skinned individuals. Int J Dermatol. 2014;53:137–41.

    Article  PubMed  Google Scholar 

  35. Hald M, Arendrup M, Svejgaard E, Lindskov R, Foged E, Saunte D. Evidence- based Danish guidelines for the treatment of Malassezia-related skin diseases. Acta Derm Venerol. 2015;95:12–9.

    Article  CAS  PubMed  Google Scholar 

  36. Hu S, Bigby M. Pityriasis versicolor. Arch Dermatol. 2010;146(10):1132–9.

    Article  PubMed  Google Scholar 

  37. Gupta AK, Foley KA. Antifungal treatment for pityriasis versicolor. J Fungi. 2015;1:13.

    Article  Google Scholar 

  38. Karray M, McKinney W. Tinea, versicolor. StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2018.

    Google Scholar 

  39. Gupta AK, Lane D, Paquet M. Systematic review of systemic treatments for tinea versicolor and evidence-based dosing regimen recommendations. J Cutan Med Surg. 2014;18(2):79–90.

    Article  CAS  PubMed  Google Scholar 

  40. Kose O, Bulent H, Riza A, Kurumlu A. Comparison of a single 400 mg dose versus a 7-day 200mg daily dose of itraconazole in the treatment of tinea versicolor. J Dermatol Treat. 2002;13:77–9.

    Article  CAS  Google Scholar 

  41. Faergemann J, Todd G, Pather S, Vawda ZFA, Gillies JD, Walford T, Barranco C, Quiring JN, Briones MA. Double-blind, randomized, placebo-controlled, dose-finding study of oral pramiconazole in the treatment of pityriasis versicolor. J Am Acad Dermatol. 2009;61:971–6.

    Article  CAS  PubMed  Google Scholar 

  42. Balevi A, Ustuner P, Kaksi S, Ozdemir M. Narrow-band UV-B phototherapy: an effective and reliable treatment alternative for extensive and recurrent pityriasis versicolor. J Dermatol Treat. 2018;29(3):252–5.

    Article  CAS  Google Scholar 

  43. Want K, Nassef Y, Sahu J, Hermes H, Schwartz L. Facial involvement in progressive macular hypomelanosis. Cutis. 2018;101(4):297–300.

    Google Scholar 

  44. Pertersen RL, Scholtz C, Jensen A, Bruggemann H, Lomholt H. Propionibacterium acnes phylogenetic type III is associated with progressive macular hypomelanosis. Eur J Microbiol Immunol. 2017;7:37–45.

    Article  CAS  Google Scholar 

  45. Thng S, Long V, Chuah S, Ta VW. Efficacy and relapse rates of different treatment modalities for progressive macular hypomelanosis. Indian J Dermatol Venerol Leprol. 2016;82(6):673–6.

    Article  Google Scholar 

  46. Kim MB, Kim GW, Park HJ, Kim HS, Kim SH, Kim BS, Ko HC. Narrowband UVB treatment of progressive macular hypomelanosis. J Am Acad Dermatol. 2012;66(4):598–605.

    Article  PubMed  Google Scholar 

  47. Sim JH, Lee DJ, Lee JS, Kim YC. Comparison of the clinical efficacy of NBUVB and NBUVB with benzoyl peroxide/clindamycin in progressive macular hypomelanosis. J Eur Acad Dermatol Venereol: JEADV. 2011;25:1318–23.

    Article  CAS  PubMed  Google Scholar 

  48. Kim J, Lee DY, Lee JY, Yoon TY. Progressive macular hypomelanosis showing excellent response to oral isotretinoin. J Dermatol. 2012;39(11):937–8.

    Article  PubMed  Google Scholar 

  49. Brown F, Crane JS. Idiopathic guttate hypomelanosis. StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2018. p. 1–4.

    Google Scholar 

  50. Mazioti M. Idiopathic guttate hypomelanosis: a mini review. J Pigmentary Disord. 2015;2(10):1–4.

    Google Scholar 

  51. Falabella R, Escobar C, Giraldo N, Rovetto P, Gill J. On the pathogenesis of idiopathic guttate hypomelanosis. J Am Acad Dermatol. 1987;16:35–44.

    Article  CAS  PubMed  Google Scholar 

  52. Kakepis M, Katoulis A, Katsambas A, et al. Idiopathic guttate hypomelanosis: an electron microscopy study. J Eur Acad Dermatol Venerol. 2015;29:1435–8.

    Article  CAS  Google Scholar 

  53. Gordon J, Reed KE, Sebastian KR, Ahmed AM. Excimer light treatment for idiopathic guttate hypomelanosis: a pilot study. Dermatol Surg. 2017;43:553–7.

    Article  CAS  PubMed  Google Scholar 

  54. Kumarasinghe SP. 3–5 cryotherapy is effective in idiopathic guttate hypomelanosis. J Dermatol. 2004;31:437–9.

    Article  PubMed  Google Scholar 

  55. Asawanonda P, Sutthipong T, Prejawal N. Pimecrolimus for idiopathic guttate hypomelanosis. J Drugs Dermatol. 2010;9:238–9.

    PubMed  Google Scholar 

  56. Hexsel DM. Treatment of idiopathic guttate hypomelanosis by localized superficial dermabrasion. Dermatol Surg. 1999;25:917–8.

    Article  CAS  PubMed  Google Scholar 

  57. Wambier CG, Wambier SPDF, Soares MTPS, Breunig J, Cappel MA, Landau M. 5-fluorouracil tattooing for idiopathic guttate hypomelanosis. J Am Acad Dermatol. 2018;78:e81–2.

    Article  PubMed  Google Scholar 

  58. Bishnoi A, Parsad D. Clinical and molecular aspects of vitiligo treatments. Int J Mol Sci. 2018;19(1509):1–15.

    Google Scholar 

  59. Ezzedine K, Silverberg N. A practical approach to the diagnosis and treatment of vitiligo in children. Pediatrics. 2016;138(1):e20154126.

    Article  PubMed  Google Scholar 

  60. Agarwal S, Gupta S, Ojha A, Sinha R. Childhood vitiligo: clinicoepidemiologic profile of 268 children from the Kumaun region of Utarakhand, India. Pediatr Dermatol. 2013;30(3):348–53.

    Article  PubMed  Google Scholar 

  61. Rodrigues M, Ezzedine K, Hamzavi I, Pandya A, Harris J. New discoveries in the pathogenesis and classification of vitiligo. J Am Acad Dermatol. 2017;77:1–13.

    Article  CAS  PubMed  Google Scholar 

  62. Mason CP, Gawkrodgor DJ. Vitiligo presentation in adults. Clin Exp Dermatol. 2005;30:344–5.

    Article  CAS  PubMed  Google Scholar 

  63. Manolache L, Benea V. Stress in patients with alopecia areata and vitiligo. J Eur Acad Dermatol Venereol. 2007;21:921–8.

    Article  PubMed  Google Scholar 

  64. Tokura Y, Fujiyama T, Ikeya S, et al. Biochemical, cytological and immunological mechanisms of rhododendrol-induced leukoderma. J Dermatol Sci. 2015;77:146–9.

    Article  CAS  PubMed  Google Scholar 

  65. Ghosh S, Mukhopadhyay S. Chemical leukoderma: a clinic-aetiological study of 864 cases in the perspective of a developing country. Br J Dermatol. 2009;160:40–7.

    Article  CAS  PubMed  Google Scholar 

  66. Ezzedine K, Lim HW, Suzuki T, Katayama I, Hamzavi I, Lan CC, Goh BK, Anbar T, de Castro CS, Lee AY, et al. Revised classification/nomenclature of vitiligo and related issues: the vitiligo global issues consensus conference. Pigment Cell Melanoma Res. 2012;25(3):E1–E13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Ezzedine K, Le Thuaut A, Jouary T, Ballanger F, Taieb A, Bastuji-Gari S. Latent class analysis of a series of 717 patients with vitiligo allows the identification of two clinical subtypes. Pigment Cell Melanoma Res. 2014;27(1):134–9.

    Article  CAS  PubMed  Google Scholar 

  68. Toosi S, Orlow SJ, Manga P. Vitiligo-inducing phenols activate the unfolded protein response in melanocytes resulting in upregulation of IL6 and IL8. J Invest Dermatol. 2012;132:2601–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Richmond JM, Frisoli ML, Harris JE. Innate immune mechanisms in vitiligo: danger from within. Curr Opin Immunol. 2013;25:676–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Schallreuter KU, Moore J, Wood JM, et al. In vivo and in vitro evidence for hydrogen peroxide(H2O2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. J Investig Dermatol Symp Proc. 1999;4:91–6.

    Article  CAS  PubMed  Google Scholar 

  71. Alkhateeb A, Fain PR, Thody A, Bennett DC, Spritz RA. Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families. Pigment Cell Res. 2003;16:208–14.

    Article  PubMed  Google Scholar 

  72. Silverberg JI, Silverberg NB. Clinical features of vitiligo associated with comorbid autoimmune disease: a prospective survey. J Am Acad Dermatol. 2013;69(5):824–6.

    Article  PubMed  Google Scholar 

  73. Sakata VM, Da Silva FT, Hirata CE, De Carvalho JF, Yamamoto JH. Diagnosis and classification of Vogt-Koyanagi-Harada disease. Autoimmun Rev. 2014;13:550–5.

    Article  CAS  PubMed  Google Scholar 

  74. Alezzandrini AA. Unilateral manifestations of tapeto-retinal degeneration, vitiligo, poliosis, grey hair and hypoacousia. Ophthalmologica. 1964;147:409–19.

    Article  CAS  PubMed  Google Scholar 

  75. Faria AR, Tarle RG, Dellatorre G, Mira MT, Castro CC. Vitiligo- part 2- classification, histopathology and treatment. An Bras Dermatol. 2014;89(5):784–90.

    Article  PubMed  Google Scholar 

  76. Goh BK, Pandya AG. Presentations, signs of activity, and differential diagnosis of vitiligo. Dermatol Clin. 2017;35:135–44.

    Article  CAS  PubMed  Google Scholar 

  77. Rodrigues M, Ezzedine K, Hamzavi I, Pandya A, Harris J. Emerging treatments for vitiligo. J Am Acad Dermatol. 2017;77:17–29.

    Article  PubMed  Google Scholar 

  78. De Francesco V, Stinco G, Laspina S, Parlangeli ME, Mariuzzi L, Patrone P. Immunohistochemical study before and after narrow band (311nm) UVB treatment in vitiligo. Eur J Dermatol. 2008;18:292–6.

    PubMed  Google Scholar 

  79. Njoo MD, Bos JD, Westerhof W. Treatment of generalized vitiligo in children with narrow-band (TL-01) UVB radiation therapy. J Am Acad Dermatol. 2000;42(2 Pt 1):245–53.

    Article  CAS  PubMed  Google Scholar 

  80. Mohammad TF, Al-Jamal M, Hamzavi IH, et al. The vitiligo working group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo. J Am Acad Dermatol. 2017;76:879–88.

    Article  PubMed  Google Scholar 

  81. Li R, Qiao M, Wang X, Zhao X, Sun Q. Effect of narrow band ultraviolet B phototherapy as monotherapy or combination therapy for vitiligo: a meta-analysis. Photodermatol Photoimmunol Photomed. 2017;33:21–31.

    Article  CAS  Google Scholar 

  82. Bhatnagar A, Kanwar AJ, Parsad D, De D. Psoralen and ultraviolet A and narrow-band ultraviolet B in inducing stability in vitiligo, assessed by vitiligo disease activity score: an open prospective comparative study. J Eur Acad Dermatol Venereol. 2007;21:1381–5.

    Article  CAS  PubMed  Google Scholar 

  83. Linthorst Homan MW, Spuls PI, Nieuweboer-Krobotova L, et al. A randomized comparison of excimer laser vs narrow-band ultraviolet B phototherapy after punch grafting in stable vitiligo patients. J Eur Acad Dermatol Venereol. 2012;26(6):690–5.

    Article  CAS  PubMed  Google Scholar 

  84. Kanwar AJ, Mahajan R, Parsad D. Low-dose oral mini-pulse dexamethasone therapy in progressive unstable vitiligo. J Cutan Med Surg. 2013;17:259–68.

    Article  CAS  PubMed  Google Scholar 

  85. Singh A, Kanwar AJ, Parsad D. Mahajan. Randomized controlled study to evaluate the effectiveness of dexamethasone oral minipulse therapy vs oral minocycline in patients with active vitiligo vulgaris. Indian J Dermatol Venereol Leprol. 2014;80(1):29–35.

    Article  PubMed  Google Scholar 

  86. Singh H, Kumaran MS, Bains A, Parsad D. A randomized comparative study of oral corticosteroid minipulse and low-dose oral methotrexate in the treatment of unstable vitiligo. Dermatology. 2015;231:286–90.

    Article  CAS  PubMed  Google Scholar 

  87. Gokhale BB. Cyclophosphamide and vitiligo. Int J Dermatol. 1979;18:92.

    Article  CAS  PubMed  Google Scholar 

  88. Iannella G, Greco A, Didona D, Didona B, Granata G, Manno A, Pasquariello B, Magliulo G. Vitiligo: pathogenesis, clinical variants and treatment approaches. Autoimmun Rev. 2016;15:335–43.

    Article  CAS  PubMed  Google Scholar 

  89. Radmanesh M, Saedi K. The efficacy of combined PUVA and low-dose azathioprine for early and enhanced repigmentation in vitiligo patients. J Dermatol Treat. 2006;17:151–3.

    Article  CAS  Google Scholar 

  90. Cavalie M, Ezzedine K, Fontas E, Montaudie H, Castela E, Bahadoran P, Taieb A, Lacour JP, Passeran T. Maintenance therapy of adult vitiligo with 0.1% tacrolimus ointment: a randomized, double blind placebo-controlled study. J Invest Dermatol. 2015;135(4):970–4.

    Article  CAS  PubMed  Google Scholar 

  91. Feetham HJ, Chan JL, Pandya AG. Characterization of clinical response in patients with vitiligo undergoing autologous epidermal punch grafting. Dermatol Surg. 2012;38:14–9.

    Article  CAS  PubMed  Google Scholar 

  92. Agrawal K, Agrawal A. Vitiligo: repigmentation with dermabrasion and thin split-thickness skin graft. Dermatol Surg. 1995;21:295–300.

    Article  CAS  PubMed  Google Scholar 

  93. Gupta S, Ajith C, Kanwar AJ, Kumar B. Surgical pearl: standardized suction syringe for epidermal grafting. J Am Acad Dermatol. 2005;52:348–50.

    Article  PubMed  Google Scholar 

  94. Huggins RH, Henderson MD, Mulekar SV, et al. Melanocyte-keratinocyte transplantation procedure in the treatment of vitiligo: the experience of an academic medical center in the United States. J Am Acad Dermatol. 2012;66:785–93.

    Article  PubMed  Google Scholar 

  95. Nordlund JJ, Forget B, Kirkwood J, Lerner AB. Dermatitis produced by applications of monobenzone in patients with active vitiligo. Arch Dermatol. 1985;121:1141–4.

    Article  CAS  PubMed  Google Scholar 

  96. Lim HW, Grimes PE, Agbai O, et al. Afamelanotide and narrowband UV-phototherapy for the treatment of vitiligo: a randomized multicenter trial. JAMA Dermatol. 2015;151:42–50.

    Article  PubMed  Google Scholar 

  97. Passeron T. Medical and maintenance treatments for vitiligo. Dermatol Clin. 2017;35:163–70.

    Article  CAS  PubMed  Google Scholar 

  98. Rashighi M, Harris JE. Interfering with the IFN-gamma/CXCL 10 pathway to develop new targeted treatments for vitiligo. Ann Transl Med. 2015;3:343.

    PubMed  PubMed Central  Google Scholar 

  99. King BA, Craiglow BG. Tofacitinib citrate for the treatment of vitiligo: a pathogenesis-directed therapy. JAMA Dermatol. 2015;151(10):1110–2.

    Article  PubMed  Google Scholar 

  100. Harris JE, Rashighi M, Nguyen N, et al. Rapid skin repigmentation on oral ruxolitinib in a patient with coexisting vitiligo and alopecia areata (AA). J Am Acad Dermatol. 2016;74:370–1.

    Article  PubMed  Google Scholar 

  101. Ramien ML, Ondrejchak S, Gendron R, et al. Quality of life in pediatric patients before and after cosmetic camouflage of visible skin conditions. J Am Acad Dermatol. 2014;71(5):935–40.

    Article  PubMed  Google Scholar 

  102. Tedeschi A, Dall’Oglio F, Micali G, Schwartz RA, Janniger CK. Corrective camouflage in pediatric dermatology. Cutis. 2007;79(2):110–2.

    PubMed  Google Scholar 

  103. Rothstein B, Joshipura D, Saraiya A, et al. Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib. J Am Acad Dermatol. 2017;76:1054–60.

    Article  CAS  PubMed  Google Scholar 

  104. Grimes P, Nashawati R. The role of diet and supplements in vitiligo management. Dermatol Clin. 2017;35:235–43.

    Article  CAS  PubMed  Google Scholar 

  105. De Cuyper C. Permanent makeup: indications and complications. Clin Dermatol. 2008;26:30–4.

    Article  PubMed  Google Scholar 

  106. Shokeen D. Postinflammatory hyperpigmentation in patients with skin of color. Cutis. 2016;97(1):E9–E11.

    PubMed  Google Scholar 

  107. Nouveau S, Agrawal D, Kohl M, Bernard F, Misra N, Nayak CS. Skin hyper pigmentation in Indian population: Insights and best practice. Indian J Dermatol. 2016;61(5):487–95.

    Article  PubMed  PubMed Central  Google Scholar 

  108. Davis E, Callender V. Postinflammatory hyperpigmentation: a review of the epidemiology, clinical features, and treatment option in skin of color. J Clin Aesthet Dermatol. 2010;3(7):20–31.

    PubMed  PubMed Central  Google Scholar 

  109. Lynne C, Kraft J, Lynde C. Topical treatments for melasma and post inflammatory hyper pigmentation. Skin Therapy Lett. 2006;11(9):1–6.

    Google Scholar 

  110. Callender VD, Surin-Lord SS, Davis EC, Maclin M. Postinflammatory hyperpigmentation etiologic therapeutic considerations. Am J Clin Dermatol. 2011;12(2):87–99.

    Article  PubMed  Google Scholar 

  111. Silpa-archa N, Kohl I, Chaowattanapanit S, Lim H, Hamzavi I. Postinflammatory hyperpigmentation: a comprehensive review. J Am Acad Dermatol. 2017;77(4):591–605.

    Article  PubMed  Google Scholar 

  112. Liz N, Vafaie J, Kihiczak N, Schwartz R. Postinflammatory hyperpigmentation: a common but troubling condition. Int J Dermatol. 2004;43:362–5.

    Article  Google Scholar 

  113. Cestari T, Arellano I, Hexsel D, Ortonne JP, Latin American Pigmentary Disorders Academy. Melasma in Latin America: options for therapy and treatment algorithm. Eur Acad Dermatol Venereol. 2009;23:760–72.

    Article  CAS  Google Scholar 

  114. Oma A, Hamzavi I, Jagdeo J. Laser treatments for postinflammatory hyperpigmentation: a systemic review. JAMA Dermatol. 2017;153(2):199–206.

    Article  Google Scholar 

  115. Ball Arefiew KL, Hantash BM. Advances in the treatment of melasma: a review of the recent literature. Dermatol Surg. 2012;38(7):971–84.

    Article  CAS  Google Scholar 

  116. Passeron T. Melasma pathogenesis and influencing factors-an overview of the latest research. J Eur Acad Dermatol Venereol. 2013;27(1):5–6.

    Article  CAS  PubMed  Google Scholar 

  117. Ogbechie-Gode OA, Elbuluk N. Melasma: an up-to-date comprehensive review. Dermatol Ther. 2017;7:305–18.

    Article  Google Scholar 

  118. Mansouri P, Farshi S, Hashemi Z, Kasraee B. Evaluation of the efficacy of cysteamine 5% cream in the treatment of epidermal melasma: a randomized double-blind placebo-controlled trial. British Journal of Dermatology. 2015;173:209–17.

    Google Scholar 

  119. Rodrigues M, Panda A. Melasma: clinical diagnosis and management options. Aust J Dermatol. 2015;56:151–63.

    Article  Google Scholar 

  120. Bourra H, Leila B. Lichen planus pigmentosus. Pan Afr Med J. 2013;15:55.

    Article  PubMed  PubMed Central  Google Scholar 

  121. Ghosh A, Coondoo A. Lichen planus pigmentosus: the controversial consensus. Indian J Dermatol. 2016;61(5):482–6.

    Article  PubMed  PubMed Central  Google Scholar 

  122. Vachiramon V, Suchonwanit P, Thadanipon K. Bilateral linear lichen planus pigmentosus associated with hepatitis C virus infection. Case Rep Dermatol. 2010;2:169–72.

    Article  PubMed  PubMed Central  Google Scholar 

  123. Weston G, Payette M. Update on lichen planus and its clinical variants. Int J Women’s Dermatol. 2015;1(3):140–9.

    Article  Google Scholar 

  124. Robles-Medez JC, Rizo-Frias P, Herz-Ruelas ME, Pandya AG, Candiani JO. Lichen planus pigmentosis and its variants: review and update. Int J Dermatol. 2017;57(5). Wiley Online Library.

    Google Scholar 

  125. Osswald SS, Proffer LH, Sartori CR. Erythema dyschromicum perstans: a case report and review. Cutis: Chatham. 2001;68(1):25–8.

    CAS  Google Scholar 

  126. Mulinari-Brenner FA, Guilherme MR, Werner B. Frontal fibrosing alopecia and lichen planus pigmentosus: diagnosis and therapeutic challenge. An Bras Dermatol. 2017;92(5):79–81.

    Article  PubMed  PubMed Central  Google Scholar 

  127. Wolfshohl JA, Geddes ERC, Stout A, Friedman PM. Improvement of erythema dyschromicum perstans using a combination of the 1,550-nm erbium-doped fractionated laser and topical tacrolimus ointment. Laser Surg Med. 2016;49(1). Wiley Online Library.

    Google Scholar 

  128. Pandya A, Guevara IL. Disorders of hyperpigmentation. Dermatol Clin. 2000;18(1):91–8.

    Article  CAS  PubMed  Google Scholar 

  129. Skorin L. Minocycline-induced hyperpigmentation of the skin, sclera, and palpebral conjunctiva. Can J Opthalmol. 2017;52:e79–81.

    Article  Google Scholar 

  130. Bahloul E, Jallouli M, Garbaa S, Marzouk S, Masmoudi A, Turki H, et al. Hydroxychloroquine-induced hyperpigmentation in systemic disease prevalence, clinical features and risk factures: a cross-sectional study of 41 cases. Lupus. 2017;26:1304–8.

    Article  CAS  PubMed  Google Scholar 

  131. Cohen PR, Eichenfield DZ. Amitriptyline-induced cutaneous hyperpigmentation: case report and review of pscychotropic drug-associated mucocutaneous hyperpigmentation. Dermatol Online J. 2016;22(2):6.

    Google Scholar 

  132. Lause M, Kamboj A, Faith EF. Dermatologic manifestations of endocrine disorders. Transl Pediatr. 2017;6(4):300–12.

    Article  PubMed  PubMed Central  Google Scholar 

  133. Michels A, Michels N. Addison disease: early detection and treatment principles. Am Fam Physician. 2014;89(7):563–8.

    PubMed  Google Scholar 

  134. Neiman LK, Chanco Turner ML. Addison’s disease. Clin Dermatol. 2006;24:276–80.

    Article  Google Scholar 

  135. Fernandez-Flores A, Cassarino DS. Histopathologic findings of cutaneous hyperpigmentation in Addison disease and immunostain of the melanocytic population. Am J Dermatopathol. 2017;39:924–7.

    Article  PubMed  Google Scholar 

  136. Banba K, Tanaka N, Fujioka A, Tajima S. Hyperpigmentation caused by hyperthyroidism: differences from the pigmentation of Addison’s disease. Clin Dermatol. 1999;43:196–8.

    Google Scholar 

  137. Leonhardt JM, Heymann WR. Thyroid disease and the skin. Dermatol Clin. 2002;20(3):473–81.

    Article  PubMed  Google Scholar 

  138. Amatya B, Agrawal S, Dhali T, Sharma S, Pandey SS. Pattern of skin and nail changes in chronic renal failure in Nepal: a hospital-based study. J Dermatol. 2008;35:140–5.

    Article  PubMed  Google Scholar 

  139. Becker S, Walter S, Witzke O, et al. Edema, hyper pigmentation, induration: 3 skin signs heralding danger in patients on maintenance hemodialysis. Medicine. 2016;95(12):1–6.

    Article  CAS  Google Scholar 

  140. Onelmis H, Sener S, Sasmaz S, Ozer A. Cutaneous changes in patient with chronic renal failure on hemodialysis. Cutan Ocul Toxicol. 2013;31(4):286–91.

    Article  Google Scholar 

  141. Fistarol SK, Itin PH. Disorders of pigmentation. J German Soc Dermatol. 2010;8:187–202.

    Google Scholar 

  142. Levy L, Zeichner JA. Dermatologic manifestation of diabetes. J Diabetes. 2012;4:68–76.

    Article  PubMed  Google Scholar 

  143. Morgan AJ, Schwartz RA. Diabetic dermopathy: a subtle sign with grave implications. J Am Acad Dermatol. 2008;58(3):447–51.

    Article  PubMed  Google Scholar 

  144. Vera-Kellter C, Andino-Navarrete R, Navajas-Galimany L. Vitamin B12 deficiency and its numerous skin manifestations. Actas Dermosifiliogr. 2015;106:762–4.

    Google Scholar 

  145. Brescoll J, Daveluy S. A review of vitamin b12 deficiency in dermatology. Am J Clin Dermatol. 2015;16:27–33.

    Article  PubMed  Google Scholar 

  146. Demir N, Dogan M, Koc A, Kaba S, Bulan K, Ozkol HU, et al. Dermatological findings of vitamin B12 deficiency and resolving time of these symptoms. Cutan Ocul Toxicol. 2014;33(1):70–3.

    Article  CAS  PubMed  Google Scholar 

  147. Higgins SP, Freemark M, Prose NS. Acanthosis nigricans: a practical approach to evaluation and management. Dermatol Online J. 2008;14(9). Retrieved from https://escholarship.org/uc/item/7mf6g290.

  148. Abraham C, Rozmus CL. Is acanthosis nigricans a reliable indicator for risk of type 2 diabetes in obese children and adolescents? A systematic review. J Sch Nurs. 2012;28(3):195–205.

    Article  PubMed  Google Scholar 

  149. Brickman WJ, Binns HJ, Jovanovis BD, Kolesky S, Mancini AJ, Metzger BE. Acanthosis nigricanss: A common finding in overweight youth. Pediatr Dermatol. 2007;24(6):601–6.

    Article  PubMed  Google Scholar 

  150. Schwartz RA. Efficacy of topical 0.1% adapalene gel for the use in the treatment of childhood acanthosis nigricans: a pilot study. Dermatol Ther. 2015;28:266.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lauren C. Payne .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Payne, L.C., Nelson, K., Callender, V.D. (2021). Management of Pigmentary Disorders. In: Li, B.S., Maibach, H.I. (eds) Ethnic Skin and Hair and Other Cultural Considerations. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-64830-5_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-64830-5_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-64829-9

  • Online ISBN: 978-3-030-64830-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics