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Ocular Rigidity and Diabetes

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Abstract

Within the last decades, diabetes mellitus has emerged as a major cause of visual disability and blindness in both developed and developing countries. High glucose concentrations lead, via several biochemical pathways, to increased production of free radical intermediates that are known to affect different physical properties of human tissues. Based on the aforementioned mechanisms, a possible correlation between ocular biomechanics and diabetic retinopathy has been suggested. Within this chapter, the pathophysiological mechanisms that may support this relationship are being covered, while a literature review with regard to ocular rigidity measurements in diabetes is being provided.

Keywords

  • Ocular rigidity
  • Diabetes
  • Diabetic retinopathy

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  • DOI: 10.1007/978-3-030-64422-2_20
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References

  1. Kharroubi AT, Darwish HM. Diabetes mellitus: the epidemic of the century. World J Diabetes. 2015;6(6):850–67.

    CrossRef  Google Scholar 

  2. International Diabetes Federation. IDF diabetes atlas. 6th ed. Brussels: International Diabetes Federation; 2013. https://www.idf.org/e-library/epidemiology-research/diabetes-atlas/19-atlas-6th-edition.html

    Google Scholar 

  3. Lee R, Wong TY, Sabanayagam C. Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss. Eye Vis (Lond). 2015;2:17.

    CrossRef  Google Scholar 

  4. Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124–36.

    CrossRef  Google Scholar 

  5. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813–20.

    CAS  CrossRef  Google Scholar 

  6. Scheler A, Spoerl E, Boehm AG. Effect of diabetes mellitus on corneal biomechanics and measurement of intraocular pressure. Acta Ophthalmol. 2012;90(6):e447–51.

    CrossRef  Google Scholar 

  7. To M, Goz A, Camenzind L, et al. Diabetes-induced morphological, biomechanical, and compositional changes in ocular basement membranes. Exp Eye Res. 2013;116:298–307.

    CAS  CrossRef  Google Scholar 

  8. Gautieri A, Redaelli A, Buehler MJ, Vesentini S. Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: candidate amino acids involved in Advanced Glycation End-products. Matrix Biol. 2014;34:89–95.

    CAS  CrossRef  Google Scholar 

  9. Paul RG, Bailey AJ. Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes. Int J Biochem Cell Biol. 1996;28(12):1297–310.

    CAS  CrossRef  Google Scholar 

  10. Tsilibary EC. Microvascular basement membranes in diabetes mellitus. J Pathol. 2003;200(4):537–46.

    CAS  CrossRef  Google Scholar 

  11. Durham JT, Herman IM. Microvascular modifications in diabetic retinopathy. Curr Diabetes Rep. 2011;11(4):253–64.

    CrossRef  Google Scholar 

  12. Zatz R, Brenner BM. Pathogenesis of diabetic microangiopathy. The hemodynamic view. Am J Med. 1986;80(3):443–53.

    CAS  CrossRef  Google Scholar 

  13. Halfter W, Candiello J, Hu H, et al. Protein composition and biomechanical properties of in vivo-derived basement membranes. Cell Adh Migr. 2013;7(1):64–71.

    CrossRef  Google Scholar 

  14. Massoudi D, Malecaze F, Galiacy SD. Collagens and proteoglycans of the cornea: importance in transparency and visual disorders. Cell Tissue Res. 2016;363(2):337–49.

    CAS  CrossRef  Google Scholar 

  15. Watson PG, Young RD. Scleral structure, organisation and disease. A review. Exp Eye Res. 2004;78(3):609–23.

    CAS  CrossRef  Google Scholar 

  16. Kase S, Ishida S, Rao NA. Immunolocalization of advanced glycation end products in human diabetic eyes: an immunohistochemical study. J Diabetes Mellitus. 2011;1:57–62.

    CrossRef  Google Scholar 

  17. Sato E, Mori F, Igarashi S, Abiko T, Takeda M, Ishiko S, Yoshida A. Corneal advanced glycation end products increase in patients with proliferative diabetic retinopathy. Diabetes Care. 2001;24(3):479–82.

    CAS  CrossRef  Google Scholar 

  18. Hadley JC, Meek KM, Malik NS. The effect of glycation on charge distribution and swelling behaviour of corneal and scleral collagen. Invest Ophthalmol Vis Sci. 1996;37:4636.

    Google Scholar 

  19. Panagiotoglou T, Tsilimbaris M, Ginis H, et al. Ocular rigidity and outflow facility in nonproliferative diabetic retinopathy. J Diabetes Res. 2015;2015:141598.

    CrossRef  Google Scholar 

  20. Poh S, Mohamed Abdul RB, Lamoureux EL, et al. Metabolic syndrome and eye diseases. Diabetes Res Clin Pract. 2016;113:86–100.

    CAS  CrossRef  Google Scholar 

  21. Friedenwald JS. Contribution to the theory and practice of tonometry. Am J Ophthalmol. 1937;20:985–1024.

    CrossRef  Google Scholar 

  22. Pallikaris IG, Kymionis GD, Ginis HS, Kounis GA, Tsilimbaris MK. Ocular rigidity in living human eyes. Invest Ophthalmol Vis Sci. 2005;46(2):409–14.

    CrossRef  Google Scholar 

  23. Arora VK, Prasad VN. The intraocular pressure and diabetes—a correlative study. Indian J Ophthalmol. 1989;37(1):10–2.

    CAS  PubMed  Google Scholar 

  24. Detorakis ET, Pallikaris IG. Ocular rigidity: biomechanical role, in vivo measurements and clinical significance. Clin Exp Ophthalmol. 2013;41(1):73–81.

    CrossRef  Google Scholar 

  25. Pallikaris IG, Kymionis GD, Ginis HS, Kounis GA, Christodoulakis E, Tsilimbaris MK. Ocular rigidity in patients with age-related macular degeneration. Am J Ophthalmol. 2006;141(4):611–5.

    CrossRef  Google Scholar 

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Giarmoukakis, A., Panagiotoglou, T. (2021). Ocular Rigidity and Diabetes. In: Pallikaris, I., Tsilimbaris, M.K., Dastiridou, A.I. (eds) Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye. Springer, Cham. https://doi.org/10.1007/978-3-030-64422-2_20

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  • DOI: https://doi.org/10.1007/978-3-030-64422-2_20

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  • Publisher Name: Springer, Cham

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