Abstract
The Yale T1D Treatment Program has utilized traditional, twice a day injections of insulin as initial treatment of youth with type 1 diabetes (T1D). Moreover, almost all of our newly diagnosed patients are admitted to the hospital when first diagnosed with T1D. While the limitations of twice a day insulin injections become more apparent over time, it is very effective during the initial treatment of T1D, since most youngsters go through a honeymoon period of increased endogenous insulin secretion during the first 6 months of diabetes. We refer to this approach as “The Bridge to Pump Treatment,” since most of our patients transition to pump therapy when metabolic control of diabetes because more difficult during the second half of the first year of treatment.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cengiz E, Tamborlane WV, Martin-Fredericksen M, Dziura J, Weinzimer SA. Early pharmacokinetic and pharmacodynamic effects of mixing lispro with glargine insulin: results of glucose clamp studies in youth with type 1 diabetes. Diabetes Care. 2010;33:1009–12.
Cengiz E, Sherr JL, Sikes K, Urban A, Weinzimer SA. Tamborlane WV for the Yale Pediatric Type 1 Diabetes Treatment Team. A bridge to insulin pump therapy: BID regimen with NPH and detemir insulin during initial treatment of youth with type 1 diabetes. Endocr Pract. 2011;6:1–17.
Heise T, Nosek L, Ronn BB, et al. Lower within-subject variability of insulin detemir in comparison to NPH insulin and insulin glargine in people with type 1 diabetes. Diabetes. 2004;53:1614–20.
Danne T, Lupke K, Walte K, Von Schuetz W, Gall MA. Insulin detemir is characterized by a consistent pharmacokinetic profile across age-groups in children, adolescents, and adults with type 1 diabetes. Diabetes Care. 2003;26:3087–92.
Diabetes Research in Children Network (DirecNet) and Type 1 Diabetes TrialNet Study Groups. Effectiveness of early intensive therapy on Beta cell preservation in type 1 diabetes. Diabetes care. Diabetes Care. 2013;36:4030–5.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Stephenson, K., Tamborlane, W.V. (2021). Initial Management of Youth with Type 1 Diabetes. In: Tamborlane, W.V. (eds) Diabetes in Children and Adolescents. Contemporary Endocrinology. Humana, Cham. https://doi.org/10.1007/978-3-030-64133-7_4
Download citation
DOI: https://doi.org/10.1007/978-3-030-64133-7_4
Published:
Publisher Name: Humana, Cham
Print ISBN: 978-3-030-64132-0
Online ISBN: 978-3-030-64133-7
eBook Packages: MedicineMedicine (R0)