Abstract
During the COVID-19 pandemic associated with high incidence, transmissibility, and mortality, this chapter focuses on three phases of the disease: initial exposure, initiation of the immune response to the agent, and finally, an inflammatory/autoimmune-like presentation with pulmonary, neurological, and renal failure and disseminated intravascular coagulation which occurs in a small proportion of the patients. The elegant demonstration of the site of interaction between the spike (S) protein of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of COVID-19, and the ACE (angiotensin-converting enzyme) 2 receptor of cells distributed throughout the body has enabled research efforts to develop pharmacological and immune countermeasures to the viral phase of the disease. This chapter rapidly reviews the molecular and structural organization of SARS-CoV-2 and its interaction with ACE2. It is followed by a discussion over the role of the major histocompatibility complex (MHC) in recognition of the virus. The importance of rapid compartmentation of the viral genome into the target cells as opposed to the binding constant of the virus for the ACE receptor is discussed. Host factors affecting the immune response to the virus are examined, and the subsequent inflammatory dysregulation enabling the cytokine storm leading to system organ failure is described. Finally, the similarities of the clinical effects of the murine hepatitis virus-JHM (a coronavirus) on multi-organ systems (liver, brain, clotting cascade) as described by Perlman and colleagues permit insights regarding the role of the interaction between the host and the virus in developing the clinical presentation of the inflammatory/autoimmune disorders that occur in multiple sclerosis, neuromyelitis optica, and more interestingly, during the third phase of COVID-19.
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References
Abiodun OA, Ola MS (2020) Role of brain renin angiotensin system in neurodegeneration: an update. Saudi J Biol Sci 27(3):905–912. https://doi.org/10.1016/j.sjbs.2020.01.026
Amanat F, Krammer F (2020) SARS-CoV-2 vaccines: status report. Immunity 52(4):583–589. https://doi.org/10.1016/j.immuni.2020.03.007
Amanat F, Duehr J, Huang C, Paessler S, Tan GS, Krammer F (2020) Monoclonal antibodies with neutralizing activity and Fc-effector functions against the Machupo virus glycoprotein. J Virol 94(5). https://doi.org/10.1128/JVI.01741-19
Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF (2020) The proximal origin of SARS-CoV-2. Nat Med 26(4):450–452. https://doi.org/10.1038/s41591-020-0820-9
Casadevall A, Pirofski LA (2020) The convalescent sera option for containing COVID-19. J Clin Invest 130(4):1545–1548. https://doi.org/10.1172/JCI138003
Chapman SJ, Hill AV (2012) Human genetic susceptibility to infectious disease. Nat Rev Genet 13(3):175–188. https://doi.org/10.1038/nrg3114
Chen J (2020) Pathogenicity and transmissibility of 2019-nCoV-A quick overview and comparison with other emerging viruses. Microbes Infect 22(2):69–71. https://doi.org/10.1016/j.micinf.2020.01.004
Colson P, Rolain JM, Raoult D (2020) Chloroquine for the 2019 novel coronavirus SARS-CoV-2. Int J Antimicrob Agents 55(3):105923. https://doi.org/10.1016/j.ijantimicag.2020.105923
Corman VM, Muth D, Niemeyer D, Drosten C (2018) Hosts and sources of endemic human coronaviruses. Adv Virus Res 100:163–188. https://doi.org/10.1016/bs.aivir.2018.01.001
Cornelissen LA, Wierda CM, van der Meer FJ, Herrewegh AA, Horzinek MC, Egberink HF, de Groot RJ (1997) Hemagglutinin-esterase, a novel structural protein of torovirus. J Virol 71(7):5277–5286
Cui J, Li F, Shi ZL (2019) Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol 17(3):181–192. https://doi.org/10.1038/s41579-018-0118-9
Demock M, Kornguth S (2019) A mechanism for the development of chronic traumatic encephalopathy from persistent traumatic brain injury. J Exp Neurosci 13:1179069519849935. https://doi.org/10.1177/1179069519849935
Doobay MF, Talman LS, Obr TD, Tian X, Davisson RL, Lazartigues E (2007) Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 292(1):R373–R381. https://doi.org/10.1152/ajpregu.00292.2006
Fehr AR, Perlman S (2015) Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol 1282:1–23. https://doi.org/10.1007/978-1-4939-2438-7_1
Gorbalenya AE, Baker SC, Baric RS, de Groot RJ, Drosten C, Gulyaeva AA, Haagmans BL, Lauber C, Leontovich AM, Neuman BW, Penzar D, Perlman S, Poon LLM, Samborskiy DV, Sidorov IA, Sola I, Ziebuhr J, Grp CS (2020) The species severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol 5(4):536–544. https://doi.org/10.1038/s41564-020-0695-z
Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, Feldt T, Green G, Green ML, Lescure FX, Nicastri E, Oda R, Yo K, Quiros-Roldan E, Studemeister A, Redinski J, Ahmed S, Bernett J, Chelliah D, Chen D, Chihara S, Cohen SH, Cunningham J, D'Arminio Monforte A, Ismail S, Kato H, Lapadula G, L'Her E, Maeno T, Majumder S, Massari M, Mora-Rillo M, Mutoh Y, Nguyen D, Verweij E, Zoufaly A, Osinusi AO, DeZure A, Zhao Y, Zhong L, Chokkalingam A, Elboudwarej E, Telep L, Timbs L, Henne I, Sellers S, Cao H, Tan SK, Winterbourne L, Desai P, Mera R, Gaggar A, Myers RP, Brainard DM, Childs R, Flanigan T (2020) Compassionate use of Remdesivir for patients with severe Covid-19. N Engl J Med 382:2327. https://doi.org/10.1056/NEJMoa2007016
Guo X, Namekata K, Kimura A, Harada C, Harada T (2017) The renin-angiotensin system regulates neurodegeneration in a mouse model of optic neuritis. Am J Pathol 187(12):2876–2885. https://doi.org/10.1016/j.ajpath.2017.08.012
He J, Tao H, Yan Y, Huang SY, Xiao Y (2020) Molecular mechanism of evolution and human infection with SARS-CoV-2. Viruses 12(4). https://doi.org/10.3390/v12040428
Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Muller MA, Drosten C, Pohlmann S (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 181:271. https://doi.org/10.1016/j.cell.2020.02.052
Hui DS, E IA, Madani TA, Ntoumi F, Kock R, Dar O, Ippolito G, McHugh TD, Memish ZA, Drosten C, Zumla A, Petersen E (2020) The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - the latest 2019 novel coronavirus outbreak in Wuhan, China. Int J Infect Dis 91:264–266. https://doi.org/10.1016/j.ijid.2020.01.009
Ibrahim IM, Abdelmalek DH, Elshahat ME, Elfiky AA (2020) COVID-19 spike-host cell receptor GRP78 binding site prediction. J Infect 80:554. https://doi.org/10.1016/j.jinf.2020.02.026
Jackson B, McGrath BP, Matthews PG, Wong C, Johnston CI (1986) Differential renal function during angiotensin converting enzyme inhibition in renovascular hypertension. Hypertension 8(8):650–654. https://doi.org/10.1161/01.hyp.8.8.650
Johnson T, Knobeloch L, Sunderland E, Juhl U, Steinhart C, Scott G, Varkais J, Fuccillo D, Sever J, Kornguth S (1976) Crystals, paracrystals, and rigid tubules in multiple sclerotic brain and spinal fluid. Lab Investig 35(3):264–271
Kirk J (1979) Pseudoviral hollow-cored vesicles in multiple sclerosis brain. Acta Neuropathol 48(1):63–66. https://doi.org/10.1007/bf00691793
Klausegger A, Strobl B, Regl G, Kaser A, Luytjes W, Vlasak R (1999) Identification of a coronavirus hemagglutinin-esterase with a substrate specificity different from those of influenza C virus and bovine coronavirus. J Virol 73(5):3737–3743
Kornguth S, Rutledge N, Perlaza G, Bray J, Hardin A (2017) A proposed mechanism for development of CTE following concussive events: head impact, water hammer injury, Neurofilament release, and autoimmune processes. Brain Sci 7(12). https://doi.org/10.3390/brainsci7120164
Li F, Li W, Farzan M, Harrison SC (2005) Structure of SARS coronavirus spike receptor-binding domain complexed with receptor. Science 309(5742):1864–1868. https://doi.org/10.1126/science.1116480
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, Ren R, Leung KSM, Lau EHY, Wong JY, Xing X, Xiang N, Wu Y, Li C, Chen Q, Li D, Liu T, Zhao J, Liu M, Tu W, Chen C, Jin L, Yang R, Wang Q, Zhou S, Wang R, Liu H, Luo Y, Liu Y, Shao G, Li H, Tao Z, Yang Y, Deng Z, Liu B, Ma Z, Zhang Y, Shi G, Lam TTY, Wu JT, Gao GF, Cowling BJ, Yang B, Leung GM, Feng Z (2020) Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 382(13):1199–1207. https://doi.org/10.1056/NEJMoa2001316
Muth D, Corman VM, Roth H, Binger T, Dijkman R, Gottula LT, Gloza-Rausch F, Balboni A, Battilani M, Rihtaric D, Toplak I, Ameneiros RS, Pfeifer A, Thiel V, Drexler JF, Muller MA, Drosten C (2018) Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission. Sci Rep 8(1):15177. https://doi.org/10.1038/s41598-018-33487-8
Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF, Connelly S, Droese B, Klaus JP, Makino S, Sawicki SG, Siddell SG, Stamou DG, Wilson IA, Kuhn P, Buchmeier MJ (2011) A structural analysis of M protein in coronavirus assembly and morphology. J Struct Biol 174(1):11–22. https://doi.org/10.1016/j.jsb.2010.11.021
Nieto-Torres JL, DeDiego ML, Verdia-Baguena C, Jimenez-Guardeno JM, Regla-Nava JA, Fernandez-Delgado R, Castano-Rodriguez C, Alcaraz A, Torres J, Aguilella VM, Enjuanes L (2014) Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis. PLoS Pathog 10(5):e1004077. https://doi.org/10.1371/journal.ppat.1004077
Perlman S, Dandekar AA (2005) Immunopathogenesis of coronavirus infections: implications for SARS. Nat Rev Immunol 5(12):917–927. https://doi.org/10.1038/nri1732
Prineas J (1972) Paramyxovirus-like particles associated with acute demyelination in chronic relapsing multiple sclerosis. Science 178(4062):760–763. https://doi.org/10.1126/science.178.4062.760
Sanche S, Lin YT, Xu C, Romero-Severson E, Hengartner N, Ke R (2020) High contagiousness and rapid spread of severe acute respiratory syndrome coronavirus 2. Emerg Infect Dis 26(7):1470. https://doi.org/10.3201/eid2607.200282
Sanders JM, Monogue ML, Jodlowski TZ, Cutrell JB (2020) Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA. https://doi.org/10.1001/jama.2020.6019
Stegbauer J, Lee DH, Seubert S, Ellrichmann G, Manzel A, Kvakan H, Muller DN, Gaupp S, Rump LC, Gold R, Linker RA (2009) Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system. Proc Natl Acad Sci U S A 106(35):14942–14947. https://doi.org/10.1073/pnas.0903602106
Tai W, He L, Zhang X, Pu J, Voronin D, Jiang S, Zhou Y, Du L (2020) Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine. Cell Mol Immunol 17:613. https://doi.org/10.1038/s41423-020-0400-4
Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D (2020) Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell 181(2):281–292. e286. https://doi.org/10.1016/j.cell.2020.02.058
Wan Y, Shang J, Graham R, Baric RS, Li F (2020) Receptor recognition by the novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS coronavirus. J Virol 94(7). https://doi.org/10.1128/JVI.00127-20
Wang Q, Zhang Y, Wu L, Niu S, Song C, Zhang Z, Lu G, Qiao C, Hu Y, Yuen KY, Wang Q, Zhou H, Yan J, Qi J (2020) Structural and functional basis of SARS-CoV-2 entry by using human ACE2. Cell 181:894. https://doi.org/10.1016/j.cell.2020.03.045
Woo PC, Huang Y, Lau SK, Yuen KY (2010) Coronavirus genomics and bioinformatics analysis. Viruses 2(8):1804–1820. https://doi.org/10.3390/v2081803
Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS (2020) Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 367(6483):1260–1263. https://doi.org/10.1126/science.abb2507
Xia H, Lazartigues E (2008) Angiotensin-converting enzyme 2 in the brain: properties and future directions. J Neurochem 107(6):1482–1494. https://doi.org/10.1111/j.1471-4159.2008.05723.x
Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q (2020) Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science 367(6485):1444–1448. https://doi.org/10.1126/science.abb2762
Zhang JS, Chen JT, Liu YX, Zhang ZS, Gao H, Liu Y, Wang X, Ning Y, Liu YF, Gao Q, Xu JG, Qin C, Dong XP, Yin WD (2005) A serological survey on neutralizing antibody titer of SARS convalescent sera. J Med Virol 77(2):147–150. https://doi.org/10.1002/jmv.20431
Zhang J, Zeng H, Gu J, Li H, Zheng L, Zou Q (2020) Progress and prospects on vaccine development against SARS-CoV-2. Vaccines (Basel) 8(2). https://doi.org/10.3390/vaccines8020153
Zhou G, Zhao Q (2020) Perspectives on therapeutic neutralizing antibodies against the novel coronavirus SARS-CoV-2. Int J Biol Sci 16(10):1718–1723. https://doi.org/10.7150/ijbs.45123
Zhou YF, Fu B, Zheng X, Wang D et al (2020) Pathogenic T cells and Inflammatory monocytesincite inflammatory storm in severe COVID-19 patients. Nat Sci Rev 7(6):998–1002. https://doi.org/10.1093/nsr/nwaa041
Zhu J, Kim J, Xiao X, Wang Y, Luo D, Chen R, Xu L, Zhang H, Xiao G, Schoggins J (2020) The immune vulnerability landscape of the 2019 Novel Coronavirus, SARS-CoV-2. bioRxiv. https://doi.org/10.1101/2020.02.08.939553
Acknowledgments
This manuscript is dedicated to Margaret Kornguth and Evelyn Marie Hawley. The authors thank them for their lifelong support of the scientific and research endeavors of their respective spouses. EMH succumbed to coronavirus disease 2019 (COVID-19) on April 17, 2020. We want to graciously acknowledge Doctors David R. Franz and John T. Pinto for their critical and valuable review of the manuscript.
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Kornguth, S.E., Hawley, R.J. (2021). Autoimmune Processes Involved in Organ System Failure Following Infection with SARS-CoV-2. In: Rezaei, N. (eds) Coronavirus Disease - COVID-19. Advances in Experimental Medicine and Biology, vol 1318. Springer, Cham. https://doi.org/10.1007/978-3-030-63761-3_21
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