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Metal Complexes as DNA Cleavage and Antimicrobial Agents

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Springer Handbook of Inorganic Photochemistry

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Abstract

In this chapter it is presented an overview regarding some examples presented in the literature regarding photochemical applications of metal complexes as DNA cleavage and microbiocidal agents. In photodynamic therapy (PDT) oxygen is required, which is photochemically converted in singlet oxygen or hydroxyl species that promotes DNA cleavage, microbial killing, and other kinds of cell damage. In these field, many strategies have been applied to improve the photophysical properties and potential as DNA intercalators of metal complexes (mainly Ru and Cu), including the utilization of an organic molecule with extended aromatic rings which presents potential ability to increase the 3MLCT lifetimes, in the case of Ru complexes.

General scheme illustrating a ruthenium metal complex reaching the cytosol and nucleus of the cell and its eventual binding and damage to DNA, leading to cell death

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Acknowledgments

E. H. S. Sousa (CNPq researcher fellowship # 308383/2018-4, Universal 403866/2016-2), L. G. F. Lopes (CNPq researcher fellowship #303355/2018-2, FUNCAP/PRONEX PR2 0101-00030.01.00/15, CAPES (23038.008968/2012-87 and 23038.000936/2018-46)) and CAPES/PRINT (8887.311905/2018-00) are thankful for financial support.

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  1. Universidade Federal do Ceará, Departamento de Quı́mica Orgânica e Inorgânica, Fortaleza, Ceará, Brazil

    Idalina M. M. de Carvalho, Florêncio S. Gouveia Jr, Eduardo H. S. Sousa & Luiz G. F. Lopes

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  1. Idalina M. M. de Carvalho
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  2. Florêncio S. Gouveia Jr
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  3. Eduardo H. S. Sousa
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  4. Luiz G. F. Lopes
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Correspondence to Luiz G. F. Lopes .

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  1. Laboratory “Photoactive Nanocomposite Materials”, Saint-Petersburg State University, Saint-Petersburg, Russia

    Detlef Bahnemann

  2. Laboratory of Photochemistry and Materials Science, Institute of Chemistry, Federal University of Uberlandia, Uberlandia, Brazil

    Antonio Otavio T. Patrocinio

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de Carvalho, I.M.M., Gouveia, F.S., Sousa, E.H.S., Lopes, L.G.F. (2022). Metal Complexes as DNA Cleavage and Antimicrobial Agents. In: Bahnemann, D., Patrocinio, A.O.T. (eds) Springer Handbook of Inorganic Photochemistry. Springer Handbooks. Springer, Cham. https://doi.org/10.1007/978-3-030-63713-2_36

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