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Role of Epigenetics in Colorectal Cancer

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Colon Cancer Diagnosis and Therapy

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Abstract

In 2018 alone, colorectal cancer (CRC) accounted for 10.2% among all cancer cases. It is known to be a consequence of accumulated alterations in the genome. Several studies on genetics have improved our understanding of CRC. While genetics play its role as the first code of genome, role of epigenetics in CRC as the second code of genome has been highlighted in the last decades. We focus on the essential factors like DNA methylation drivers-writer, reader, eraser and non-coding RNA, miRNA and long non-coding RNAs associated with CRC. 

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Abbreviations

CRC:

Colorectal cancer

LncRNA:

Long non-coding RNA

MBD1:

Methyl-CpG binding domain protein 1

miRNA:

MicroRNA

ncRNAs:

Non-coding RNAs

PVT1:

Plasmacytoma variant translocation 1

TET:

Ten-eleven translocation methylcytosine

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Author information

Authors and Affiliations

  1. Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany

    Beiping Miao & Obul Reddy Bandapalli

  2. Division of Pediatric Neuro Oncology, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany

    Beiping Miao & Obul Reddy Bandapalli

  3. Department of Biotechnology and Bioinformatics, Birla Institute of Scientific Research (BISR), Statue Circle, Jaipur, Rajasthan, India

    Sonal Gupta & Prashanth Suravajhala

  4. Department of Paediatrics, Sawai Man Singh Medical College, Jaipur, Rajasthan, India

    Sonal Gupta

  5. Advance Milk Testing Research Laboratory, Post Graduate Institute of Veterinary Education and Research (RAJUVAS), Jaipur, Rajasthan, India

    Manisha Mathur

  6. Medical Faculty, University of Heidelberg, Heidelberg, Germany

    Obul Reddy Bandapalli

Authors
  1. Beiping Miao
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  2. Sonal Gupta
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  3. Manisha Mathur
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  4. Prashanth Suravajhala
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  5. Obul Reddy Bandapalli
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Correspondence to Obul Reddy Bandapalli .

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Editors and Affiliations

  1. Department of Hematology and Medical Oncology, Emory University, Atlanta, GA, USA

    Ganji Purnachandra Nagaraju

  2. Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India

    Dhananjay Shukla

  3. Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India

    Naveen Kumar Vishvakarma

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Miao, B., Gupta, S., Mathur, M., Suravajhala, P., Bandapalli, O.R. (2021). Role of Epigenetics in Colorectal Cancer. In: Nagaraju, G.P., Shukla, D., Vishvakarma, N.K. (eds) Colon Cancer Diagnosis and Therapy. Springer, Cham. https://doi.org/10.1007/978-3-030-63369-1_6

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