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Mechanobiology of Atherosclerosis

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Part of the Cardiac and Vascular Biology book series (Abbreviated title: Card. vasc. biol., volume 8)

Abstract

Vascular mechanobiology deals with the question of how different physical forces and changes in the mechanical properties of single cells and entire tissue structures contribute to cell differentiation, physiology, initiation, and progression of disease development. This review surveys new findings and progress in the research field of atherosclerosis in recent years. Moreover, it aims to integrate different aspects to demonstrate the interlacing and integration of certain mechanisms in the pathogenesis of atherosclerosis.

Keywords

Mechanical forces Glycocalyx Transcription factors Epigenetics Arterial stiffness 

Abbreviations

ApoE

Apolipoprotein E

ICAM-1

Intercellular adhesion molecule-1

LIM

Named after their initial discovery in the proteins Lin11, Isl-1, Mec-3

NADPH

Nicotinamide adenine dinucleotide phosphate hydrate

NOS3

Endothelial nitric oxide synthase (eNOS)

NOX

NADPH oxidase

ROS

Reactive oxygen species

Smad

Acronym refers to the Caenorhabditis elegans Sma (small worm phenotype) and the Drosophila Mad (mothers against decapentaplegic) gene family

SUMO

Small Ubiquitin-related Modifier

TAZ

Transcriptional co-activator with PDZ-binding motif

TNF-α

Tumor necrosis factor-α

VCAM-1

Vascular cell adhesion protein-1

VSMCs

Vascular smooth muscle cells

YAP

Yes-associated protein

Notes

Compliance with Ethical Standards

Conflict of Interest The author declares that he has no conflict of interest.

Ethical Approval This chapter does not contain any studies with human participants or animals.

Sources of Funding None.

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Authors and Affiliations

  1. 1.Department of Cardiovascular PhysiologyInstitute of Physiology and Pathophysiology, Heidelberg UniversityHeidelbergGermany

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