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Syntheses and Biological Applications of Fluorescent Probes

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Functional Properties of Advanced Engineering Materials and Biomolecules

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Abstract

Fluorescent probes are powerful tools with vast potential for application in chemical biology. The specific characteristics of the main group of fluorophores coupled with the development of new techniques, have boosted their investigation in various research areas. For instance, the necessity of fluorescent tags applicable in different studies of subcellular localization and mechanisms of action of bioactive compounds has increased the development of fluorophores and new synthetic protocols toward the application in medicinal chemistry. This chapter discuss the first syntheses as well as modern synthetic methods, and some biological applications of the main fluorescent probes for drug discovery.

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  1. Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP), Universidade de São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, 14090-901, Brazil

    Suzane Quintana Gomes & Carlos Henrique Tomich de Paula da Silva

  2. Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP), Universidade de São Paulo, Av. do Café, s/n, Ribeirão Preto, 14040-903, Brazil

    Ismael Raitz, Mariana Pegrucci Barcelos & Carlos Henrique Tomich de Paula da Silva

  3. Centro Brasileiro de Pesquisas Fisicas, Rua Dr. Xavier Sigaud, 150-Urca, Rio de Janeiro, 22290-180, Brazil

    Carlton Anthony Taft

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    Felipe A. La Porta

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Gomes, S.Q., Raitz, I., Barcelos, M.P., Taft, C.A., de Paula da Silva, C.H.T. (2021). Syntheses and Biological Applications of Fluorescent Probes. In: La Porta, F.A., Taft, C.A. (eds) Functional Properties of Advanced Engineering Materials and Biomolecules. Engineering Materials. Springer, Cham. https://doi.org/10.1007/978-3-030-62226-8_18

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