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Coronary Blood Flow Reserve and Myocardial Ischemia

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Nuclear Cardiology

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Abstract

Radionuclide myocardial perfusion imaging (MPI) using single-photon emission tomography (SPECT) or positron emission tomography (PET) is used worldwide in the assessment of patients with suspected or known coronary artery disease (CAD) [1–6]. In the recent decades, the better understanding of the coronary physiology and advances in technology have raised the possibility of noninvasive measurement of myocardial blood flow (MBF). The dynamic acquisition enables the absolute radiotracer quantification in mL/min/g and substantially increments the diagnostic and prognostic value of the nuclear studies [6–13]. This chapter will review the basic concepts of coronary physiology, the current evidence supporting MBF use in the clinical scenario, and the protocols for MFB acquisition with PET and SPECT.

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Abbreviations

CAD:

Coronary artery disease

CBF:

Coronary blood flow

CMD:

Coronary microvascular dysfunction

IWOS:

Ischemia without stenosis

MBF:

Myocardial blood flow

MFR:

Myocardial flow reserve

MFR:

Myocardial flow reserve

MPI:

Myocardial perfusion imaging

PET:

Positron emission tomography

SPECT:

Single-photon emission tomography

SWOI:

Stenosis without ischemia

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Authors and Affiliations

  1. Diagnosticos da America SA, Clínica de Diagnóstico por Imagem, Rio de Janeiro, Brazil

    Fernanda Erthal & Ronaldo Lima

  2. Department of Cardiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    Ronaldo Lima

  3. Fonte Imagem, Rio de Janeiro, Brazil

    Ronaldo Lima

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  1. Fernanda Erthal
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  1. Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

    Cláudio Tinoco Mesquita

  2. Hospital Vitória, Rio de Janeiro, Rio de Janeiro, Brazil

    Maria Fernanda Rezende

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Erthal, F., Lima, R. (2021). Coronary Blood Flow Reserve and Myocardial Ischemia. In: Mesquita, C.T., Rezende, M.F. (eds) Nuclear Cardiology. Springer, Cham. https://doi.org/10.1007/978-3-030-62195-7_8

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