Abstract
Multiplanar capability and superior tissue contrast differentiation render magnetic resonance (MR) imaging the preferred method of examination of lesions affecting the hypothalamic-pituitary axis. MR imaging is the modality of choice for evaluating the anatomy and pathologic conditions of the hypothalamus. The MR imaging differential diagnosis of various hypothalamic disease entities relies on understanding the signal characteristics and postcontrast enhancement patterns. MR imaging features in addition to the patient’s demographics and clinical presentation will help the clinician to treat the patient appropriately.
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References
Swaab DF, Hofman MA, Lucassen PJ, Purba JS, Raadsheer FC, Van de Nes JA. Functional neuroanatomy and neuropathology of the human hypothalamus. Anat Embryol (Berl). 1993;187(4):317–30.
Swaab DF. The human hypothalamus in metabolic and episodic disorders. Prog Brain Res. 2006;153:3–45.
Bao AM, Swaab DF. The human hypothalamus in mood disorders: the HPA axis in the center. IBRO Rep. 2019;6:45–53.
Miller MJ, Mark LP, Yetkin FZ, Ho KC, Haughton VM, Estkowski L, et al. Imaging white matter tracts and nuclei of the hypothalamus: an MR-anatomic comparative study. AJNR Am J Neuroradiol. 1994;15(1):117–21.
Saeki N, Sunami K, Kubota M, Murai H, Takanashi J, Iuchi T, et al. Heavily T2-weighted MR imaging of white matter tracts in the hypothalamus: normal and pathologic demonstrations. AJNR Am J Neuroradiol. 2001;22(8):1468–75.
Fujii Y, Nakayama N, Nakada T. High-resolution T2-reversed magnetic resonance imaging on a high magnetic field system. Technical note. J Neurosurg. 1998;89(3):492–5.
Freeman JL, Coleman LT, Wellard RM, Kean MJ, Rosenfeld JV, Jackson GD, et al. MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. AJNR Am J Neuroradiol. 2004;25(3):450–62.
Gray H. Anatomy of the human body. Philadelphia: Lea & Febiger; 1918. Bartleby.com, 2000. Available at http://www.bertelby.com/107/. Accessed 15 Oct 2019.
Nauta WJ. Limbic system and hypothalamus: anatomical aspects. Physiol Rev Suppl. 1960;4:102–4.
Braak H, Braak E. Anatomy of the human hypothalamus (chiasmatic and tuberal region). Prog Brain Res. 1992;93:3–14; discussion -6.
Braak H, Braak E. The hypothalamus of the human adult: chiasmatic region. Anat Embryol (Berl). 1987;175(3):315–30.
Saleem SN, Said AH, Lee DH. Lesions of the hypothalamus: MR imaging diagnostic features. Radiographics. 2007;27(4):1087–108.
Tsai SL, Laffan E. Congenital growth hormone deficiency - a review with a focus on neuroimaging. Eur Endocrinol. 2013;9(2):136–40.
Berkowitz F, Lee PJ, Martin AL, Martin MM. Enlargement of the proximal pituitary stalk associated with spontaneous recovery from multiple pituitary hormone deficiencies. AJNR Am J Neuroradiol. 2008;29(8):1601–2.
Arita K, Kurisu K, Kiura Y, Iida K, Otsubo H. Hypothalamic hamartoma. Neurol Med Chir (Tokyo). 2005;45(5):221–31.
Freeman JL. The anatomy and embryology of the hypothalamus in relation to hypothalamic hamartomas. Epileptic Disord. 2003;5(4):177–86.
Arita K, Ikawa F, Kurisu K, Sumida M, Harada K, Uozumi T, et al. The relationship between magnetic resonance imaging findings and clinical manifestations of hypothalamic hamartoma. J Neurosurg. 1999;91(2):212–20.
Kurt G, Dogulu F, Kaymaz M, Emmez H, Onk A, Baykaner MK. Hypothalamic lipoma adjacent to mamillary bodies. Childs Nerv Syst. 2002;18(12):732–4.
Di Pietro P, Debbia C, Paola Fondelli M. Pediatric hypothalamic lipoma with hypothermia--case report. Brain Dev. 2004;26(1):61–2.
Caldarelli M, Massimi L, Kondageski C, Di Rocco C. Intracranial midline dermoid and epidermoid cysts in children. J Neurosurg. 2004;100(5 Suppl Pediatrics):473–80.
Ikushima I, Korogi Y, Hirai T, Sugahara T, Shigematsu Y, Komohara Y, et al. MR of epidermoids with a variety of pulse sequences. AJNR Am J Neuroradiol. 1997;18(7):1359–63.
Indulkar S, Hsich GE. Spontaneous rupture of intracranial dermoid cyst in a child. Neurology. 2011;77(23):2070.
Voelker JL, Campbell RL, Muller J. Clinical, radiographic, and pathological features of symptomatic Rathke’s cleft cysts. J Neurosurg. 1991;74(4):535–44.
Wenger M, Simko M, Markwalder R, Taub E. An entirely suprasellar Rathke’s cleft cyst: case report and review of the literature. J Clin Neurosci. 2001;8(6):564–7.
Byun WM, Kim OL, Kim D. MR imaging findings of Rathke’s cleft cysts: significance of intracystic nodules. AJNR Am J Neuroradiol. 2000;21(3):485–8.
Sumida M, Uozumi T, Mukada K, Arita K, Kurisu K, Eguchi K. Rathke cleft cysts: correlation of enhanced MR and surgical findings. AJNR Am J Neuroradiol. 1994;15(3):525–32.
Adamson TE. Craniopharyngiomas. Neurosurgery. 1996;39(5):1070–1.
Adamson TE, Wiestler OD, Kleihues P, Yasargil MG. Correlation of clinical and pathological features in surgically treated craniopharyngiomas. J Neurosurg. 1990;73(1):12–7.
Kollias SS, Barkovich AJ, Edwards MS. Magnetic resonance analysis of suprasellar tumors of childhood. Pediatr Neurosurg. 1991;17(6):284–303.
Sartoretti-Schefer S, Wichmann W, Aguzzi A, Valavanis A. MR differentiation of adamantinous and squamous-papillary craniopharyngiomas. AJNR Am J Neuroradiol. 1997;18(1):77–87.
MĂ¼ller HL. The Diagnosis and Treatment of Craniopharyngioma. Neuroendocrinology. 2020;110(9–10):753–66. https://doi.org/10.1159/000504512. Epub 2019 Nov 4. PMID: 31678973.
Pusey E, Kortman KE, Flannigan BD, Tsuruda J, Bradley WG. MR of craniopharyngiomas: tumor delineation and characterization. AJR Am J Roentgenol. 1987;149(2):383–8.
Matsutani M. Pineal germ cell tumors. Prog Neurol Surg. 2009;23:76–85.
Guedes BF, Souza MNP, Barbosa B, Frassetto FP, Lucato LT, Ono CR, et al. Intracranial germinoma causing cerebral haemiatrophy and hypopituitarism. Pract Neurol. 2018;18(4):306–10.
Mootha SL, Barkovich AJ, Grumbach MM, Edwards MS, Gitelman SE, Kaplan SL, et al. Idiopathic hypothalamic diabetes insipidus, pituitary stalk thickening, and the occult intracranial germinoma in children and adolescents. J Clin Endocrinol Metab. 1997;82(5):1362–7.
Campagna M, Opocher E, Viscardi E, Calderone M, Severino SM, Cermakova I, et al. Optic pathway glioma: long-term visual outcome in children without neurofibromatosis type-1. Pediatr Blood Cancer. 2010;55(6):1083–8.
Delman BN. Imaging of pediatric pituitary abnormalities. Endocrinol Metab Clin North Am. 2009;38(4):673–98.
Johnsen DE, Woodruff WW, Allen IS, Cera PJ, Funkhouser GR, Coleman LL. MR imaging of the sellar and juxtasellar regions. Radiographics. 1991;11(5):727–58.
Schubiger O, Haller D. Metastases to the pituitary--hypothalamic axis. An MR study of 7 symptomatic patients. Neuroradiology. 1992;34(2):131–4.
Kastrup O, Wanke I, Maschke M. Neuroimaging of infections of the central nervous system. Semin Neurol. 2008;28(4):511–22.
Prayer D, Grois N, Prosch H, Gadner H, Barkovich AJ. MR imaging presentation of intracranial disease associated with Langerhans cell histiocytosis. AJNR Am J Neuroradiol. 2004;25(5):880–91.
Kalra AA, Riel-Romero RM, Gonzalez-Toledo E. Lymphocytic hypophysitis in children: a novel presentation and literature review. J Child Neurol. 2011;26(1):87–94.
Gubbi S, Hannah-Shmouni F, Stratakis CA, Koch CA. Primary hypophysitis and other autoimmune disorders of the sellar and suprasellar regions. Rev Endocr Metab Disord. 2018;19(4):335–47.
Bathla G, Singh AK, Policeni B, Agarwal A, Case B. Imaging of neurosarcoidosis: common, uncommon, and rare. Clin Radiol. 2016;71(1):96–106.
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Thakkar, R.S., Berkowitz, F. (2021). Neuroimaging of the Human Hypothalamus. In: Uwaifo, G.I. (eds) The Human Hypothalamus. Contemporary Endocrinology. Humana, Cham. https://doi.org/10.1007/978-3-030-62187-2_3
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DOI: https://doi.org/10.1007/978-3-030-62187-2_3
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