Abstract
Existence of multipotent pericytes (MPCs) implies that microvasculature plays a role not only as ducts for blood, but also as a reservoir for stem cells that contributes to tissue maintenance and regeneration. Nerve network is closely linked to the distribution of microvasculature, namely the ‘nerve and vessel wiring’. Thus, microvasculature may function to support the fundamental systems for the maintenance of multicellular organisms, i.e. blood circulating-, cell supplementing- and information processing- systems. Although this research field is gaining much attention for their potential importance in biological science and clinical application, the lack of an appropriate marker for MPCs impedes our understanding of their pathophysiological roles. Using the new marker, EphA7, capillary stem cells (CapSCs) can be isolated from crude PC fractions as a cell population with high regenerative potency. This chapter describes the role of MPCs, especially a new subpopulation of MPCs, CapSCs, in the microvascular functions to maintain multicellular organisms.
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Acknowledgement
I would like to thank the labo members, especially M. Kabara, Y. Yoshida, K. Kano, Y. Tomita, K. Horiuchi, A. Minoshima, T. Matsuki and also Dr. N. Hasebe and T. Araki for useful comments. This work was supported by grants JSPS KAKENHI (17H04170, 17 K19368, 18K16379, 19K16969, 19K16905), and in part by Daiichi Sankyo Co. Ltd., and Asbio Pharmer Co. Ltd. And OideCapiSEA, Inc.
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Kawabe, JI. (2021). EphA7+ Multipotent Pericytes and Their Roles in Multicellular Organisms. In: Birbrair, A. (eds) Biology of Pericytes – Recent Advances. Stem Cell Biology and Regenerative Medicine, vol 68. Humana, Cham. https://doi.org/10.1007/978-3-030-62129-2_8
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DOI: https://doi.org/10.1007/978-3-030-62129-2_8
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