Abstract
In this chapter, the reader will get acquainted with the clinical features, diagnostic challenges, and management strategies in patients with hypophysitis – an inflammatory disease affecting the pituitary gland.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Suggested Reading
Albarel F, Castinetti F, Brue T. Management of endocrine disease: immune check point inhibitors-induced hypophysitis. Eur J Endocrinol. 2019;181(3):R107–18. https://doi.org/10.1530/EJE-19-0169.
Castinetti F, Albarel F, Archambeaud F, Bertherat J, Bouillet B, Buffier P, Briet C, Cariou B, Caron P, Chabre O, Chanson P, Cortet C, Do Cao C, Drui D, Haissaguerre M, Hescot S, Illouz F, Kuhn E, Lahlou N, Merlen E, Raverot V, Smati S, Verges B, Borson-Chazot F. French Endocrine Society Guidance on endocrine side effects of immunotherapy. Endocr Relat Cancer. 2019;26(2):G1–G18. https://doi.org/10.1530/ERC-18-0320.
Gutenberg A, Bell JJ, Lupi I, Tzou SC, Landek-Salgado MA, Kimura H, Su J, Karaviti LP, Salvatori R, Caturegli P. Pituitary and systemic autoimmunity in a case of intrasellar germinoma. Pituitary. 2011;14(4):388–94. https://doi.org/10.1007/s11102-009-0187-x.
Honegger J, Buchfelder M, Schlaffer S, Droste M, Werner S, Strasburger C, Störmann S, Schopohl J, Kacheva S, Deutschbein T, Stalla G, Flitsch J, Milian M, Petersenn S, Elbelt U, Pituitary Working Group of the German Society of Endocrinology. Treatment of primary hypophysitis in Germany. J Clin Endocrinol Metab. 2015;100(9):3460–9. https://doi.org/10.1210/jc.2015-2146.
Honegger J, Schlaffer S, Menzel C, Droste M, Werner S, Elbelt U, Strasburger C, Störmann S, Küppers A, Streetz-van der Werf C, Deutschbein T, Stieg M, Rotermund R, Milian M, Petersenn S, Pituitary Working Group of the German Society of Endocrinology. Diagnosis of primary hypophysitis in Germany. J Clin Endocrinol Metab. 2015;100(10):3841–9. https://doi.org/10.1210/jc.2015-2152.
Kleinschmidt-DeMasters BK, Lillehei KO, Hankinson TC. Review of xanthomatous lesions of the sella. Brain Pathol. 2017;27(3):377–95. https://doi.org/10.1111/bpa.12498.
Li G, ZHang C, Sun Y, Mu Q, Huang H. Xanthogranulomatous pituitary adenoma: a case report and literature review. Mol Clin Oncol. 2018;8(3):445–8. https://doi.org/10.3892/mco.2018.1547.
Nagi S. Primary hypophysitis. In: Bonneville JF, Bonneville F, Cattin F, Nagi S, editors. MRI of the pituitary gland. Cham: Springer; 2016. p. 283–91.
Nakata Y, Sato N, Masumoto T, Mori H, Akai H, Nobusawa H, Adachi Y, Oba H, Ohtomo K. Parasellar T2 dark sign on MR imaging in patients with lymphocytic hypophysitis. Am J Neuroradiol. 2010;31(10):1944–50. https://doi.org/10.3174/ajnr.A2201.
Nishioka H, Shibuya M, Ohtsuka K, Ikeda Y, Haraoka J. Endocrinological and MRI features of pituitary adenomas with marked xanthogranulomatous reaction. Neuroradiology. 2010;52(11):997–1002. https://doi.org/10.1007/s00234-010-0675-8.
Pekic S, Bogosavljevic V, Peker S, Doknic M, Miljic D, Stojanovic M, Skender Gazibara M, Manojlovic Gacic E, Popovic V. Lymphocytic hypophysitis successfully treated with stereotactic radiosurgery: case report and review of the literature. J Neurol Surg A Cent Eur Neurosurg. 2018;79(1):77–85. https://doi.org/10.1055/s-0037-1604079.
Prete A, Salvatori R. Hypophysitis. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A, Hershman JM, Kaltsas G, Koch C, Kopp P, Korbonits M, McLachlan R, Morley JE, New M, Perreault L, Purnell J, Rebar R, Singer F, Trence DL, Vinik A, Wilson DP, editors. Endotext [Internet]. South Dartmouth: MDText.com, Inc.; 2000. -.2018 Aug 15.
Ved R, Logier N, Leach P, Davies JS, Hayhurst C. Pituitary xanthogranulomas: clinical features, radiological appearance and post-operative outcomes. Pituitary. 2018;21(3):256–65. https://doi.org/10.1007/s11102-017-0859-x.
Zhou X, Zhu H, Yao Y, Lian X, Feng F, Wang L, Liu S, Deng K, You H, Yang H, Lu L. Etiological spectrum and pattern of change in pituitary stalk thickening: experience in 321 patients. J Clin Endocrinol Metab. 2019;104(8):3419–27. https://doi.org/10.1210/jc.2018-02297.
Acknowledgments
This study was supported by a grant from the Ministry of Science of Republic of Serbia (Project 175033).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Pekic, S., Miljic, D., Stojanovic, M., Albarel, F., Bonneville, JF., Popovic, V. (2021). Hypophysitis. In: Igaz, P. (eds) Practical Clinical Endocrinology. Springer, Cham. https://doi.org/10.1007/978-3-030-62011-0_8
Download citation
DOI: https://doi.org/10.1007/978-3-030-62011-0_8
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-62010-3
Online ISBN: 978-3-030-62011-0
eBook Packages: MedicineMedicine (R0)