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Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals

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Cannabinoids and Sleep

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1297))

Abstract

The cannabinoids are a family of chemical compounds that can be either synthesized or naturally derived. These compounds have been shown to modulate a wide variety of biological processes. In this chapter, the studies detailing the effects of cannabinoids on sleep in laboratory animals are reviewed. Both exogenous and endogenous cannabinoids generally appear to decrease wakefulness and alter rapid eye movement (REM) and non-REM sleep in animal models. In addition, cannabinoids potentiate the effects of sedative-hypnotic drugs. However, the individual contributions of each cannabinoid on sleep processes is more nuanced and may depend on the site of action in the central nervous system. Many studies investigating the mechanism of cannabinoid effects on sleep suggest that the effects of cannabinoids on sleep are mediated via cannabinoid receptors; however, some evidence suggests that some sleep effects may be elicited via non-cannabinoid receptor-dependent mechanisms. More research is necessary to fully elucidate the role of each compound in modulating sleep processes.

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Authors and Affiliations

  1. Department of Psychology, Indiana University Northwest, Gary, IN, USA

    Maureen L. Petrunich-Rutherford

  2. Center for Sleep and Health Research, University of Illinois at Chicago, Chicago, IL, USA

    Michael W. Calik

  3. Department of Biobehavioral Nursing Science, University of Illinois at Chicago, Chicago, IL, USA

    Michael W. Calik

Authors
  1. Maureen L. Petrunich-Rutherford
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  2. Michael W. Calik
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Correspondence to Michael W. Calik .

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Editors and Affiliations

  1. School of Medicine, University of the Republic, Montevideo, Uruguay

    Jaime M. Monti

  2. Somnogen Canada Inc., Toronto, ON, Canada

    S. R. Pandi-Perumal

  3. División Ciencias de la Salud, Universidad Anáhuac Mayab, Merida, Mexico

    Eric Murillo-Rodríguez

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Petrunich-Rutherford, M.L., Calik, M.W. (2021). Effects of Cannabinoid Agonists and Antagonists on Sleep in Laboratory Animals. In: Monti, J.M., Pandi-Perumal, S.R., Murillo-Rodríguez, E. (eds) Cannabinoids and Sleep. Advances in Experimental Medicine and Biology, vol 1297. Springer, Cham. https://doi.org/10.1007/978-3-030-61663-2_7

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