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Human Population Genomics pp 89–121Cite as

Methods for Association Studies

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Abstract

Association studies are a key approach to evaluating the relationship between genetic factors and phenotypes or traits. This chapter presents general methods for genetic association studies in unrelated humans. Topics covered include types of association studies, study design considerations, measurement of genetic information, and analytical techniques. This material provides readers with background for interpreting results from association studies and for undertaking their own studies.

Keywords

  • Genetic association study
  • GWAS
  • Candidate gene study

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  • DOI: 10.1007/978-3-030-61646-5_5
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Acknowledgments

This work was supported by National Institutes of Health grants R25CA112355, R01CA088164, and R01CA201358.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA

    Rebecca E. Graff, Caroline G. Tai, Linda Kachuri & John S. Witte

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  1. Rebecca E. Graff
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  2. Caroline G. Tai
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  3. Linda Kachuri
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  4. John S. Witte
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Correspondence to Rebecca E. Graff .

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  1. Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA

    Prof. Dr. Kirk E. Lohmueller

  2. Integrative Biology, University of California, Berkeley, CA, USA

    Prof. Dr. Rasmus Nielsen

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Graff, R.E., Tai, C.G., Kachuri, L., Witte, J.S. (2021). Methods for Association Studies. In: Lohmueller, K.E., Nielsen, R. (eds) Human Population Genomics. Springer, Cham. https://doi.org/10.1007/978-3-030-61646-5_5

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