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Introducing Drugonfly; A Novel Computer-Aided Drug Repurposing Pipeline Based on Genomic, Structural and Physicochemical Profiles

Conference paper
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Part of the Lecture Notes in Computer Science book series (LNCS, volume 12462)

Abstract

Herein, we are proposing a novel and radical pipeline that will facilitate the repurposing of approved drugs in an unprecedented way that will eventually yield invaluable insights and results that will aid the pharma-medical domain to tackle many more pathologies using weaponry that has already been approved, is safe for the public, is very rapid relatively to conventional drug design and requires no further significant investment to be made. The ultimate goal is to develop a novel clinical concept and establish a computer-aided pipeline that will facilitate and rationalize the repurposing of approved drugs, orphan drugs and generics. The end result of the described pipeline is a competitive and reliable software that will be made available for the scientific community.

Keywords

Drug design Drug repurposing Bioinformatics Metagenomics Data mining Data analytics 

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Genetics and Computational Biology Group, Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and BiotechnologyAgricultural University of AthensAthensGreece
  2. 2.Laboratory of Molecular Endocrinology, Division of Endocrinology and Metabolism, Center of ClinicalExperimental Surgery and Translational Research, Biomedical Research Foundation, Academy of AthensAthensGreece
  3. 3.University Research, Institute of Maternal and Child Health and Precision MedicineMedical School, National and Kapodistrian University of AthensAthensGreece

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