Prenatal Programming of Neurodevelopment: Structural and Functional Changes

Demers, Catherine H.; Aran, Özlü; Glynn, Laura M.; Davis, Elysia Poggi

doi:10.1007/978-3-030-60159-1_9

Catherine H. Demers^5,6^na1,
Özlü Aran⁵^na1,
Laura M. Glynn^7,8^na1 &
…
Elysia Poggi Davis^5,7,9^na1

1548 Accesses
10 Citations

Abstract

Prenatal maternal stress is highly prevalent and predicts many child psychopathologies. Here, we apply the fetal programming hypothesis as an organizational framework to address the possibility that exposure to maternal stress during pregnancy affects fetal neurodevelopmental pathways that enhance risk for subsequent psychopathology. This chapter evaluates the empirical literature assessing the ontogenetic influences of prenatal maternal stress on child brain maturation. We conducted a systematic review investigating prenatal stress broadly defined and any direct measure of brain development including electroencephalography (EEG) and event-related potential (ERP), structural and functional magnetic resonance imaging (MRI), and diffusion tensor imaging (DTI). Lastly, we propose the following areas as promising avenues of future research to further elucidate the underlying etiology of such findings: investigation of sex/gender specific mechanisms, genetic interactions, pre- and postnatal effects, and opportunities for intervention.

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Acknowledgments

We gratefully acknowledge the support from the National Institute of Mental Health (P50MH096889, EPD, LMG and R01MH10966, EPD) and T32 Training Fellowship (MH015442-402, CHD).

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Authors Catherine H. Demers and Özlü Aran have equally contributed to this chapter.

Authors and Affiliations

Department of Psychology, University of Denver, Denver, CO, USA
Catherine H. Demers, Özlü Aran & Elysia Poggi Davis
Department of Psychiatry, University of Colorado Denver Anschutz Medical Campus, Denver, CO, USA
Catherine H. Demers
Department of Psychiatry and Human Behavior, University of California-Irvine, Irvine, CA, USA
Laura M. Glynn & Elysia Poggi Davis
Department of Psychology, Chapman University, Orange, CA, USA
Laura M. Glynn
Neurodevelopmental Research Program, Department of Psychology, University of Denver, Denver, CO, USA
Elysia Poggi Davis

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Department of Psychiatry, McGill University, Montreal, QC, Canada
Ashley Wazana & Eszter Székely &
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada
Ashley Wazana & Eszter Székely &
BC Children‘s Hospital, BC Women‘s Hospital and Health Centre, Vancouver, BC, Canada
Tim F. Oberlander
Department of Pediatrics Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
Tim F. Oberlander

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Demers, C.H., Aran, Ö., Glynn, L.M., Davis, E.P. (2021). Prenatal Programming of Neurodevelopment: Structural and Functional Changes. In: Wazana, A., Székely, E., Oberlander, T.F. (eds) Prenatal Stress and Child Development. Springer, Cham. https://doi.org/10.1007/978-3-030-60159-1_9

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DOI: https://doi.org/10.1007/978-3-030-60159-1_9
Published: 20 April 2021
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