Abstract
Brittle nails are a polymorphic disorder characterized by increased fragility or loss of flexibility of the nail plate. The prevalence is approximately 20%, with women being nearly twice as likely to be affected than men. Patients may complain of both aesthetic and functional problems. The cardinal clinical features are onychoschizia, or lamellar splitting and peeling of the nail plate’s free edge, and onychorrhexis, or longitudinal ridging of the nail plate. The pathophysiology is not fully understood, and there are few evidence-based treatments. In this chapter, we review the etiology, history, physical findings, and treatment options for brittle nails.
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Abbreviations
- FDA:
-
Food and Drug Administration
- HPCH:
-
Hydroxypropyl chitosan
- TOWL:
-
Transonychial water loss
References
Iorizzo M, Pazzaglia M, M Piraccini B, Tullo S, Tosti A. Brittle nails. J Cosmet Dermatol. 2004;3(3):138–44.
Garson J, Baltenneck F, Leroy F, Riekel C, Müller M. Histological structure of human nail as studied by synchrotron X-ray microdiffraction. Cell Mol Biol (Noisy-le-Grand, France). 2000;46(6):1025–34.
Cashman MW, Sloan SB. Nutrition and nail disease. Clin Dermatol. 2010;28(4):420–5.
Iorizzo M. Tips to treat the 5 most common nail disorders: brittle nails, onycholysis, paronychia, psoriasis, onychomycosis. Dermatol Clin. 2015;33(2):175–83.
Wertz PW, Swartzendruber DC, Abraham W, Madison KC, Downing DT. Essential fatty acids and epidermal integrity. Arch Dermatol. 1987;123(10):1381–4.
Gniadecka M, Nielsen OF, Christensen DH, Wulf HC. Structure of water, proteins, and lipids in intact human skin, hair, and nail. J Investig Dermatol. 1998;110(4):393–8.
van de Kerkhof PC, Pasch MC, Scher RK, Kerscher M, Gieler U, Haneke E, et al. Brittle nail syndrome: a pathogenesis-based approach with a proposed grading system. J Am Acad Dermatol. 2005;53(4):644–51.
Stern DK, Diamantis S, Smith E, Wei H, Gordon M, Muigai W, et al. Water content and other aspects of brittle versus normal fingernails. J Am Acad Dermatol. 2007;57(1):31–6.
Shemer A, Daniel CR III. Common nail disorders. Clin Dermatol. 2013;31(5):578–86.
Samman P. Nail formation and some nail disorders. J Soc Cosmet Chem. 1972;23:405–13.
Scher RK. Brittle nails. Int J Dermatol. 1989;28(8):515–6.
Murdan S. Nail disorders in older people, and aspects of their pharmaceutical treatment. Int J Pharm. 2016;512(2):405–11.
Jemec G, Agner T, Serup J. Transonychial water loss: relation to sex, age and nail-plate thickness. Br J Dermatol. 1989;121(4):443–6.
Walters K, Flynn G. Permeability characteristics of the human nail plate. Int J Cosmet Sci. 1983;5(6):231–46.
Draelos ZD. Cosmetic consultation understanding and treating brittle nails. Cosmet Dermatol. 2009;22(12):598–609.
Finlay AY, Frost P, Keith AD, Snipes W. An assessment of factors influencing flexibility of human fingernails. Br J Dermatol. 1980;103(4):357–65.
Wessel S, Gniadecka M, Jemec GB, Wulf HC. Hydration of human nails investigated by NIR-FT-Raman spectroscopy. Biochim Biophys Acta. 1999;1433(1–2):210–6.
Warner RR, Stone KJ, Boissy YL. Hydration disrupts human stratum corneum ultrastructure. J Investig Dermatol. 2003;120(2):275–84.
Farran L, Ennos AR, Eichhorn SJ. The effect of humidity on the fracture properties of human fingernails. J Exp Biol. 2008;211(23):3677–81.
Sarifakioglu E, Yilmaz A, Gorpelioglu C. Nail alterations in 250 infant patients: a clinical study. J Eur Acad Dermatol Venereol. 2008;22(6):741–4.
Duarte AF, Correia O, Baran R. Nail plate cohesion seems to be water independent. Int J Dermatol. 2009;48(2):193–5.
Wallis MS, Bowen WR, Guin JD. Pathogenesis of onychoschizia (lamellar dystrophy). J Am Acad Dermatol. 1991;24(1):44–8.
Lubach D, Beckers P. Wet working conditions increase brittleness of nails, but do not cause it. Dermatology. 1992;185(2):120–2.
Egawa M, Ozaki Y, Takahashi M. In vivo measurement of water content of the fingernail and its seasonal change. Skin Res Technol. 2006;12(2):126–32.
Klauder JV, Brown H. Sulphur content of hair and of nails in abnormal states: II. Nails. Arch Dermatol Syphilol. 1935;31(1):26–34.
Runne U, Orfanos C. The human nail: structure, growth and pathological changes. Curr Probl Dermatol. 1981;9:102.
Silver H, Chiego B. Nails and nail changes: III. Brittleness of nails (fragilitas unguium). J Investig Dermatol. 1940;3(5):357–74.
Chen AF, Chimento SM, Hu S, Sanchez M, Zaiac M, Tosti A. Nail damage from gel polish manicure. J Cosmet Dermatol. 2012;11(1):27–9.
Baran R. Nail cosmetics. Am J Clin Dermatol. 2002;3(8):547–55.
Rieder EA, Tosti A. Cosmetically induced disorders of the nail with update on contemporary nail manicures. J Clin Aesthet Dermatol. 2016;9(4):39.
Lubach D, Cohrs W, Wurzinger R. Incidence of brittle nails. Dermatologica. 1986;172(3):144–7.
Tan C, Zhu WY. Thumbnail lamellar onychoschizia in a tea-picker. Int J Dermatol. 2006;45(11):1390–1.
Piraccini BM, Antonucci A, Iorizzo M, Pazzaglia M, Tosti A. Occupational nail fragility in a professional violist. Contact Dermatitis. 2004;51(1):35–6.
Gequelim GC, Kubota CY, Sanches S, Dranka D, Mejia MM, Sumiya FM, et al. Perception of brittle nails in dermatologic patients: a cross-sectional study. An Bras Dermatol. 2013;88(6):1022–5.
Baran R, Moulin G. The bidet nail: a French variant of the worn-down nail syndrome. Br J Dermatol. 1999;140(2):377.
Wollina U, Berger M, Karte K. Calculation of nail plate and nail matrix parameters by 20 MHz ultrasound in healthy volunteers and patients with skin disease. Skin Res Technol. 2001;7(1):60–4.
Dahdah MJ, Scher RK. Nail diseases related to nail cosmetics. Dermatol Clin. 2006;24(2):233–9, vii.
Brosche T, Dressler S, Platt D. Age-associated changes in integral cholesterol and cholesterol sulfate concentrations in human scalp hair and finger nail clippings. Aging Clin Exp Res. 2001;13(2):131–8.
Helmdach M, Thielitz A, Röpke E-M, Gollnick H. Age and sex variation in lipid composition of human fingernail plates1. Skin Pharmacol Physiol. 2000;13(2):111–9.
Tziotzios C, Lee JY, Brier T, Saito R, Hsu C-K, Bhargava K, et al. Lichen planus and lichenoid dermatoses: clinical overview and molecular basis. J Am Acad Dermatol. 2018;79(5):789–804.
Jacobsen AA, Tosti A. Trachyonychia and twenty-nail dystrophy: a comprehensive review and discussion of diagnostic accuracy. Skin Appendage Disord. 2016;2(1–2):7–13.
Chelidze K, Lipner SR. Nail changes in alopecia areata: an update and review. Int J Dermatol. 2018;57(7):776–83.
Choi JW, Kim BR, Seo E, Youn SW. Identification of nail features associated with psoriasis severity. J Dermatol. 2017;44(2):147–53.
Kechijian P. Brittle fingernails. Dermatol Clin. 1985;3(3):421–9.
Singal A, Arora R. Nail as a window of systemic diseases. Indian Dermatol Online J. 2015;6(2):67.
Marie I, Gremain V, Nassermadji K, Richard L, Joly P, Menard J-F, et al. Nail involvement in systemic sclerosis. J Am Acad Dermatol. 2017;76(6):1115–23.
Jabbour SA. Cutaneous manifestations of endocrine disorders. Am J Clin Dermatol. 2003;4(5):315–31.
Damasco FM, Geskin LJ, Akilov OE. Nail changes in Sezary syndrome: a single-center study and review of the literature. J Cutan Med Surg. 2019;23:380–7.
Fanti P, Tosti A, Morelli R, Galbiati G. Nail changes as the first sign of systemic amyloidosis. Dermatology. 1991;183(1):44–6.
Motswaledi MH, Mayayise M. Nail changes in systemic diseases. S Afr Fam Pract. 2010;52(5):409–13.
Noriega L, Di Chiacchio NG, Rezende FC, Di Chiacchio N. Periungual lesion due to secondary syphilis. Skin Appendage Disord. 2016;2(3–4):116–9.
Kaur I, Chakrabarti A, Dogra S, Rai R, Kumar B. Nail involvement in leprosy: a study of 300 patients. Int J Lepr Other Mycobact Dis. 2003;71(4):320–7.
Salem A, Gamil H, Hamed M, Galal S. Nail changes in patients with liver disease. J Eur Acad Dermatol Venereol. 2010;24(6):649–54.
Chao SC, Lee JY. Brittle nails and dyspareunia as first clues to recurrences of malignant glucagonoma. Br J Dermatol. 2002;146(6):1071–4.
Gordon KA, Vega JM, Tosti A. Trachyonychia: a comprehensive review. Indian J Dermatol Venereol Leprol. 2011;77(6):640–5.
Dimitris R, Ralph D. Management of simple brittle nails. Dermatol Ther. 2012;25(6):569–73.
Lubach D, Wurzinger R. Trace elements in samples of brittle and nonbrittle finger nails. Derm Beruf Umwelt. 1986;34(2):37–9.
Seshadri D, De D. Nails in nutritional deficiencies. Indian J Dermatol Venereol Leprol. 2012;78(3):237.
Swenne I, Engström I. Medical assessment of adolescent girls with eating disorders: an evaluation of symptoms and signs of starvation. Acta Paediatr. 2005;94(10):1363–71.
Schulze UM, Pettke-Rank CV, Kreienkamp M, Hamm H, Bröcker EB, Wewetzer C, et al. Dermatologic findings in anorexia and bulimia nervosa of childhood and adolescence. Pediatr Dermatol. 1999;16(2):90–4.
Bitar C, Farooqui MZ, Valdez J, Saba NS, Soto S, Bray A, et al. Hair and nail changes during long-term therapy with ibrutinib for chronic lymphocytic leukemia. JAMA Dermatol. 2016;152(6):698–701.
Dika E, Patrizi A, Ribero S, Fanti PA, Starace M, Melotti B, et al. Hair and nail adverse events during treatment with targeted therapies for metastatic melanoma. Eur J Dermatol. 2016;26(3):232–9.
Piraccini BM, Iorizzo M, Antonucci A, Tosti A. Drug-induced nail abnormalities. Expert Opin Drug Saf. 2004;3(1):57–65.
Lacouture M, Sibaud V. Toxic side effects of targeted therapies and immunotherapies affecting the skin, oral mucosa, hair, and nails. Am J Clin Dermatol. 2018;19(Suppl 1):31–9.
Baran R, Schoon D. Nail fragility syndrome and its treatment. J Cosmet Dermatol. 2004;3(3):131–7.
Önder M, Öztas MO, Öztas P. Isotretinoin-induced nail fragility and onycholysis. J Dermatol Treat. 2001;12(2):115–6.
Erpolat S, Eser A, Kaygusuz I, Balci H, Kosus A, Kosus N. Nail alterations during pregnancy: a clinical study. Int J Dermatol. 2016;55(10):1172–5.
Geyer AS, Onumah N, Uyttendaele H, Scher RK. Modulation of linear nail growth to treat diseases of the nail. J Am Acad Dermatol. 2004;50(2):229–34.
Weistenhöfer W, Uter W, Drexler H. Protection during production: problems due to prevention? Nail and skin condition after prolonged wearing of occlusive gloves. J Toxic Environ Health A. 2017;80(7–8):396–404.
Abdullah L, Abbas O. Common nail changes and disorders in older people: diagnosis and management. Can Fam Physician. 2011;57(2):173–81.
El-Domyati M, Abdel-Wahab H, Abdel-Azim E. Nail changes and disorders in elderly Egyptians. J Cosmet Dermatol. 2014;13(4):269–76.
Chinazzo M, Lorette G, Baran R, Finon A, Saliba E, Maruani A. Nail features in healthy term newborns: a single-centre observational study of 52 cases. J Eur Acad Dermatol Venereol. 2017;31(2):371–5.
Singh G, Haneef NS, Uday A. Nail changes and disorders among the elderly. Indian J Dermatol Venereol Leprol. 2005;71(6):386.
Oranges T, Aleid N, Faleri S, Tosti A. Patch test nails. Contact Dermatitis. 2016;75(6):394–5.
Sherber NS, Hoch AM, Coppola CA, Carter EL, Chang HL, Barsanti FR, et al. Efficacy and safety study of tazarotene cream 0.1% for the treatment of brittle nail syndrome. Cutis. 2011;87(2):96–103.
Tosti A, Piraccini BM. Nail disorders. St. Louis: Elsevier; 2018.
Maddy AJ, Tosti A. Hair and nail diseases in the mature patient. Clin Dermatol. 2018;36(2):159–66.
Lassus A. Colloidal silicic acid for oral and topical treatment of aged skin, fragile hair and brittle nails in females. J Int Med Res. 1993;21(4):209–15.
Rosenberg S, Oster KA, Kallos A, Burroughs W. Further studies in the use of gelatin in the treatment of brittle nails. AMA Arch Derm. 1957;76(3):330–5.
Haneke E. Onychocosmeceuticals. J Cosmet Dermatol. 2006;5(1):95–100.
Scheinfeld N, Dahdah MJ, Scher R. Vitamins and minerals: their role in nail health and disease. J Drugs Dermatol. 2007;6(8):782–7.
Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. J Cosmet Dermatol. 2017;16(4):520–6.
Comben N, Clark R, Sutherland D. Clinical observations on the response of equine hoof defects to dietary supplementation with biotin. Vet Rec. 1984;115(25–26):642–5.
Colombo VE, Gerber F, Bronhofer M, Floersheim GL. Treatment of brittle fingernails and onychoschizia with biotin: scanning electron microscopy. J Am Acad Dermatol. 1990;23(6):1127–32.
Hochman L, Scher R, Meyerson M. Brittle nails: response to daily biotin supplementation. Cutis. 1993;51(4):303–5.
Soleymani T, Lo KS, Shapiro J. The infatuation with biotin supplementation: is there truth behind its rising popularity? A comparative analysis of clinical efficacy versus social popularity. J Drugs Dermatol. 2017;16(5):496–500.
Administration FDA. The FDA warns that biotin may interfere with lab tests: FDA safety communication 2017. Available from: https://www.fda.gov/medical-devices/safety-communications/fda-warns-biotin-may-interfere-lab-tests-fda-safety-communication
Patel DP, Swink SM, Castelo-Soccio L. A review of the use of biotin for hair loss. Skin Appendage Disord. 2017;3(3):166–9.
Lipner SR. Rethinking biotin therapy for hair, nail, and skin disorders. J Am Acad Dermatol. 2018;78(6):1236–8.
De Berker D. The physical basis of cosmetic defects of the nail plate. J Cosmet Dermatol. 2002;1(1):35–42.
Iorizzo M, Piraccini BM, Tosti A. Nail cosmetics in nail disorders. J Cosmet Dermatol. 2007;6(1):53–8.
Batory M, Namieciński P, Rotsztejn H. Evaluation of structural damage and pH of nail plates of hands after applying different methods of decorating. Int J Dermatol. 2019;58(3):311–8.
Batory M, Wołowiec-Korecka E, Rotsztejn H. The effect of various primers improving adhesiveness of gel polish hybrids on pH, TOWL and overall nail plates condition. J Cosmet Dermatol. 2019;18:1529–38.
Nanda S, Grover C. Utility of gel nails in improving the appearance of cosmetically disfigured nails: experience with 25 cases. J Cutan Aesthet Surg. 2014;7(1):26.
Mackay-Wiggan J, Marji J, Walt JG, Campbell A, Coppola C, Chakraborty B, et al. Topical cyclosporine versus emulsion vehicle for the treatment of brittle nails: a randomized controlled pilot study. J Drugs Dermatol. 2014;13(10):1232–9.
Sparavigna A, Setaro M, Genet M, Frisenda L. Equisetum arvense in a new transungual technology improves nail structure and appearance. J Plast Dermatol. 2006;2(1):31–8.
Sparavigna A, Caserini M, Tenconi B, De I. Effects of a novel nail lacquer based on hydroxypropyl-chitosan (HPCH) in subjects with fingernail onychoschizia. J Dermatol Clin Res. 2014;2(2):1013.
Petrosian S, Meehan S, Lasky S, Saitta P. A case of median nail dystrophy treated with poly urea-urethane solution. JAOCD. 2003;75(3):39.
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Geizhals, S., Lipner, S.R. (2021). Brittle Nails. In: Baran, R.L. (eds) Advances in Nail Disease and Management. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-59997-3_10
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