Abstract
The yellow nail syndrome is a condition presenting with a triad: yellow nails, lymphedema, and pleural effusions. Any of these conditions may be either missing or present in isolation. Systemic drugs are mainly used in rhumatoid arthritis and titanium exposure, principally found in food and dental or surgical devices, should be looked for. The role of malignancies is still debatable. The most effective systemic treatments are fluconazole and clarithromycin. They may be associated with intralesional triamcinolone acetonide in the distal phalanges.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Samman PD, White WF. The “Yellow nail” syndrome. Br J Dermatol. 1964;76:153–7.
Vignes S, Baran R. Yellow nail syndrome: a review. Orphanet J Rare Dis. 2017;12:42.
Mishra AK, George L. Yellow nail syndrome in rheumatoid arthritis: an aetiology beyond thiol drugs. Oxford Med Case Rep. 2016;3:37–40.
Berglund F, Cazlmark B. Titanium, sinusitis and the YNS. Biol Trace Elem Res. 2011;143:1–7.
Decker A, Doly D, Scher RK. Role of titanium in the development of YNS. Skin Appendage Disord. 2015;1:28–30.
Maldonado F, Tazelaar H, Wang C-W, et al. Yellow nail syndrome. Analysis of 41 consecutive patients. Chest. 2008;134:375–81.
Chiriac A, Naznean A, Podoleanu C, Stolnicu S. Transient yellow discoloration of the nails for differential diagnosis with yellow nail syndrome. Orphanet J Rare Dis. 2017;12(1):article 159.
Szolnoky G, Lakatos B, Husz S, et al. Improvement in lymphatic function and partial resolution of nails after complex decongestive physiotherapy in yellow nail syndrome. Int J Dermatol. 2005;44:501–3.
Polat AK, Dang HT, Soran A. YNS treatment of lymphedema using low pressure compression. Lymphat Res Biol. 2012;10(1):30–2.
Yamagishi T, Hatanaka N, Kamemura H, et al. Idiopathic yellow nail syndrome successfully treated with OK-432. Intern Med. 2007;46:1127–30.
Kurin M, Wiesen J, Mehta AC. Yellow nail syndrome: a case report and review of treatment options. Clin Respir J. 2017;11:405–10.
El Alami J, Galicier L, Huynh S, Frumholtz L, Bagot M, de Masson A, Vignes S, Bouaziz JD. Congenital yellow nail syndrome presenting with eyelid lymphedema and fetal hydrops. JAAD Case Rep. 2019;5:1010–2.
Nanda A, Al-Essa FA, El-Shafel WM, Alsaleh QA. Congenital yellow nail syndrome: a case report and its relationship to nonimmune fetal hydrops. Pediatr Dermatol. 2010;27(5):533–4.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Baran, R.L., Vignes, S. (2021). Yellow Nail Syndrome. In: Baran, R.L. (eds) Advances in Nail Disease and Management. Updates in Clinical Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-59997-3_1
Download citation
DOI: https://doi.org/10.1007/978-3-030-59997-3_1
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-59996-6
Online ISBN: 978-3-030-59997-3
eBook Packages: MedicineMedicine (R0)