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Human Endogenous Natural Products

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Progress in the Chemistry of Organic Natural Products 114

Part of the book series: Progress in the Chemistry of Organic Natural Products ((POGRCHEM,volume 114))

Abstract

Natural products are a class of chemical compounds that are biosynthesized by living organisms, including humans. Endogenous natural products are produced by human cells as well as by the human microbiome. This contribution describes the current understanding and recent progress made on endogenous natural products that are produced by human cells, including amines, steroids, and fatty acid-derived natural products. The co-metabolism and natural product produced by the human microbiome will also be described, including the involvement of tryptophan, bile acids, choline, and cysteine. New strategies and technologies have been introduced that can be applied to identify and characterize those natural products produced by the human microbiome in terms of their composition and physiological function.

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Acknowledgements

Financial support from the National Natural Science Foundation of China Grant (21625201, 21961142010, 21661140001, 91853202, and 21521003), the National Key Research and Development Program of China (2017YFA0505200), the Beijing Outstanding Young Scientist Program (BJJWZYJH01201910001001) is gratefully acknowledged.

Author information

Authors and Affiliations

  1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, 282 Chengfu Road, Haidian District, Beijing, China

    Yingjie Bai & Liyun Zhang

  2. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, College of Chemistry and Molecular Engineering and Peking-Tsinghua Center for Life Science, Peking University, 282 Chengfu Road, Haidian District, Beijing, China

    Xiaoguang Lei

Authors
  1. Yingjie Bai
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  2. Liyun Zhang
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  3. Xiaoguang Lei
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Correspondence to Xiaoguang Lei .

Editor information

Editors and Affiliations

  1. College of Pharmacy, Ohio State University, Columbus, OH, USA

    A. Douglas Kinghorn

  2. Institute of Organic Chemistry, Johannes Kepler University, Linz, Oberösterreich, Austria

    Heinz Falk

  3. School of Pharmacy, University of East Anglia, NORWICH, UK

    Simon Gibbons

  4. Graduate School of Pharmaceutical Science, Hokkaido University, Fukuoka, Japan

    Jun'ichi Kobayashi

  5. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Yoshinori Asakawa

  6. School of Pharmaceutical Sciences, South Central University for Nationalities, Wuhan, China

    Ji-Kai Liu

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Bai, Y., Zhang, L., Lei, X. (2021). Human Endogenous Natural Products. In: Kinghorn, A.D., Falk, H., Gibbons, S., Kobayashi, J., Asakawa, Y., Liu, JK. (eds) Progress in the Chemistry of Organic Natural Products 114. Progress in the Chemistry of Organic Natural Products, vol 114. Springer, Cham. https://doi.org/10.1007/978-3-030-59444-2_4

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