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The Many Microenvironments of Ovarian Cancer

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Tumor Microenvironments in Organs

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1296))

Abstract

High-grade serous ovarian cancer (HGSOC) is the most common and deadly subtype of ovarian cancer as it is commonly diagnosed after substantial metastasis has already occurred. The past two decades have been an active era in HGSOC research, with new information on the origin and genomic signature of the tumor cell. Additionally, studies have begun to characterize changes in the HGSOC microenvironment and examine the impact of these changes on tumor progression and response to therapies. While this knowledge may provide valuable insight into better prognosis and treatments for HGSOCs, its collection, synthesis, and application are complicated by the number of unique microenvironments in the disease—the initiating site (fallopian tube), first metastasis (ovary), distal metastases (peritoneum), and recurrent/platinum-resistant setting. Here, we review the state of our understanding of these diverse sites and highlight remaining questions.

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Acknowledgments

Funding was provided by grants to Pamela K. Kreeger from the NIH (1R01CA232517, 1R01CA240965, and 1R21CA227922), the American Cancer Society (133003-MBG-18-206-01-COUN), and a Pilot grant from the Rivkin Center for Ovarian Cancer.

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  1. Authors Hannah M. Micek and Mike R. Visetsouk have been equally contributed for this chapter.

Authors and Affiliations

  1. Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA

    Hannah M. Micek, Mike R. Visetsouk, Andrew J. Fleszar & Pamela K. Kreeger

  2. University of Wisconsin Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

    Pamela K. Kreeger

  3. Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

    Pamela K. Kreeger

  4. Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

    Pamela K. Kreeger

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  1. Hannah M. Micek
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  4. Pamela K. Kreeger
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Correspondence to Pamela K. Kreeger .

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  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA, Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Alexander Birbrair

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Micek, H.M., Visetsouk, M.R., Fleszar, A.J., Kreeger, P.K. (2020). The Many Microenvironments of Ovarian Cancer. In: Birbrair, A. (eds) Tumor Microenvironments in Organs. Advances in Experimental Medicine and Biology, vol 1296. Springer, Cham. https://doi.org/10.1007/978-3-030-59038-3_12

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