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The Microbiome, Probiotics, and Prebiotics

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Abstract

In this chapter, there will be discussion of the skin microbiome formation, composition, function, and regional topographical differences. Similarly, the gut microbiome will be reviewed, and dysbiosis at each site as well as the consequences of such dysbiosis will be entertained. Specifically, the interaction between the skin microbiome and gut microbiome will be discussed with respect to acne and rosacea. Although information to date is limited with respect to treatment options, therapeutic interventions which may work through microbial systems will be presented. Finally, ideas for future research will be put forth.

Keywords

  • Microbiome
  • Skin microbiome
  • Gut microbiome
  • Gut–brain–skin axis
  • Probiotics
  • Prebiotics

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References

  1. Lloyd-Price J, Abu-Ali G, Huttenhower C. The healthy human microbiome. Genome Med. 2016;8:51.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  2. Prescott SL, Larcombe DL, Logan AC, West C, Burks W, Caraballo L, et al. The skin microbiome: impact of modern environments on skin ecology, barrier integrity, and systemic immune programming. World Allergy Organ J. 2017;10:29.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  3. Ladizinski B, McLean R, Lee KC, Elpern DJ, Eron L. The human skin microbiome. Int J Dermatol. 2014;53:1177–9.

    CrossRef  PubMed  Google Scholar 

  4. Weyrich LS, Dixit S, Farrer AG, Cooper AJ, Cooper AJ. The skin microbiome: associations between altered microbial communities and disease. Australas J Dermatol. 2015;56:268–74.

    CrossRef  PubMed  Google Scholar 

  5. Zeeuwen PLJM, Kleerebezem M, Timmerman HM, Schalkwijk J. Microbiome and skin diseases. Curr Opin Allergy Clin Immunol. 2013;13:514–20.

    CrossRef  CAS  PubMed  Google Scholar 

  6. Chen YE, Tsao H. The skin microbiome: current perspectives and future challenges. J Am Acad Dermatol. 2013;69:143–55.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  7. Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R. Current understanding of the human microbiome. Nat Med. 2018;24:392–400.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  8. Yamazaki Y, Nakamura Y, Núñez G. Role of the microbiota in skin immunity and atopic dermatitis. Allergol Int. 2017;66:539–44.

    CrossRef  CAS  PubMed  Google Scholar 

  9. Schommer NN, Gallo RL. Structure and function of the human skin microbiome. Trends Microbiol. 2013;21:660–8.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  10. Pflughoeft KJ, Versalovic J. Human microbiome in health and disease. Annu Rev Pathol. 2012;7:99–122.

    CrossRef  CAS  PubMed  Google Scholar 

  11. Muszer M, Noszczyńska M, Kasperkiewicz K, Skurnik M. Human microbiome: when a friend becomes an enemy. Arch Immunol Ther Exp. 2015;63:287–98.

    CrossRef  CAS  Google Scholar 

  12. Kong HH, Segre JA. The molecular revolution in cutaneous biology: investigating the skin microbiome. J Invest Dermatol. 2017;137:e119–22.

    CrossRef  CAS  PubMed  Google Scholar 

  13. Baba H, Masuyama A, Yoshimura C, Aoyama Y, Takano T, Ohki K. Oral intake of lactobacillus helveticus-fermented milk whey decreased transepidermal water loss and prevented the onset of sodium dodecylsulfate-induced dermatitis in mice. Biosci Biotechnol Biochem. 2010;74:18–23.

    CrossRef  CAS  PubMed  Google Scholar 

  14. Philippe D, Blum S, Benyacoub J. Oral Lactobacillus paracasei improves skin barrier function recovery and reduces local skin inflammation. Eur J Dermatol. 2011;21:279–80.

    CrossRef  PubMed  Google Scholar 

  15. Gueniche A, Philippe D, Bastien P, Reuteler G, Blum S, Castiel-Higounenc I, et al. Randomised double-blind placebo-controlled study of the effect of Lactobacillus paracasei NCC 2461 on skin reactivity. Benef Microbes. 2014;5:137–45.

    CrossRef  CAS  PubMed  Google Scholar 

  16. Benyacoub J, Bosco N, Blanchard C, Demont A, Philippe D, Castiel-Higounenc I, et al. Immune modulation property of Lactobacillus paracasei NCC2461 (ST11) strain and impact on skin defences. Benef Microbes. 2014;5:129–36.

    CrossRef  CAS  PubMed  Google Scholar 

  17. Poutahidis T, Kearney SM, Levkovich T, Qi P, Varian BJ, Lakritz JR, et al. Microbial symbionts accelerate wound healing via the neuropeptide hormone oxytocin. PLoS One. 2013;e78898:8.

    Google Scholar 

  18. Salem I, Ramser A, Isham N, Ghannoum MA. The gut microbiome as a major regulator of the gut-skin axis. Front Microbiol. 2018;9:1459.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  19. Fabbrocini G, Bertona M, Picazo Ó, Pareja-Galeano H, Monfrecola G, Emanuele E. Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. Benef Microbes. 2016;7:625–30.

    CrossRef  CAS  PubMed  Google Scholar 

  20. Bowe W, Patel NB, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine. Benef Microbes. 2014;5:185–99.

    CrossRef  CAS  PubMed  Google Scholar 

  21. Stokes JH, Pillsbury DM. The effect on the skin of emotional and nervous states: III. Theoretical and practical consideration of a gastro-intestinal mechanism. Arch Dermatol Syphilol. 1930;22:962–93.

    CrossRef  Google Scholar 

  22. Deng Y, Wang H, Zhou J, Mou Y, Wang G, Xiong X. Patients with acne vulgaris have a distinct gut microbiota in comparison with healthy controls. Acta Derm Venereol. 2018;98:783–90.

    CrossRef  CAS  PubMed  Google Scholar 

  23. Yan H-M, Zhao H-J, Guo D-Y, Zhu P-Q, Zhang C-L, Jiang W. Gut microbiota alterations in moderate to severe acne vulgaris patients. J Dermatol. 2018;45:1166–71.

    CrossRef  CAS  PubMed  Google Scholar 

  24. Marchetti F, Capizzi R, Tulli A. Efficacy of regulators of the intestinal bacterial flora in the therapy of acne vulgaris. Clin Ter. 1987;122:339–43. [In Italian].

    CAS  PubMed  Google Scholar 

  25. Volkova LA, Khalif IL, Kabanova IN. Impact of the impaired intestinal microflora on the course of acne vulgaris. Klin Med. 2001;79:39–41.

    CAS  Google Scholar 

  26. Jung GW, Tse JE, Guiha I, Rao J. Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. J Cutan Med Surg. 2013;7:114–22.

    CrossRef  Google Scholar 

  27. Clark AK, Haas KN, Sivamani RK. Edible plants and their influence on the gut microbiome and acne. Int J Mol Sci. 2017;18(5):E1070. https://doi.org/10.3390/ijms18051070.

    CrossRef  CAS  PubMed  Google Scholar 

  28. Lu PH, Hsu CH. Does supplementation with green tea extract improve acne in post-adolescent women? A randomized, double-blind, and placebo-controlled clinical trial. Complement Ther Med. 2016;25:159–63.

    CrossRef  CAS  PubMed  Google Scholar 

  29. Thappa DM, Dogra J. (1994) Nodulocystic acne: oral gugulipid versus tetracycline. J Dermatol. 1994;21:729–31.

    CrossRef  CAS  PubMed  Google Scholar 

  30. He J-M, Mu Q. The medicinal uses of the genus Mahonia in traditional Chinese medicine: an ethnopharmacological, phytochemical and pharmacological review. J Ethnopharmacol. 2015;175:668–83.

    CrossRef  CAS  PubMed  Google Scholar 

  31. Egeberg A, Weinstock LB, Thyssen EP, Gislason GH, Thyssen JP. Rosacea and gastrointestinal disorders: a population-based cohort study. Br J Dermatol. 2017;176:100–6.

    CrossRef  CAS  PubMed  Google Scholar 

  32. Drago F, De Col E, Agnoletti AF, Schiavetti I, Savarino V, Rebora A, et al. The role of small intestinal bacterial overgrowth in rosacea: a 3-year follow-up. J Am Acad Dermatol. 2016;75:e113–5.

    CrossRef  PubMed  Google Scholar 

  33. Musthaq S, Mazuy A, Jakus J. The microbiome in dermatology. Clin Dermatol. 2018;36:390–8.

    CrossRef  PubMed  Google Scholar 

  34. Kendall SN. Remission of rosacea induced by reduction of gut transit time. Clin Exp Dermatol. 2004;29:297–9.

    CrossRef  CAS  PubMed  Google Scholar 

  35. Nam J-H, Yun Y, Kim H-S, Kim H-N, Jung HJ, Chang Y, et al. Rosacea and its association with enteral microbiota in Korean females. Exp Dermatol. 2018;27:37–42.

    CrossRef  CAS  PubMed  Google Scholar 

  36. Fortuna MC, Garelli V, Pranteda G, Romaniello F, Cardone M, Carlesimo M, et al. A case of scalp rosacea treated with low dose doxycycline and probiotic therapy and literature review on therapeutic options. Dermatol Ther. 2016;29:249–51.

    CrossRef  CAS  PubMed  Google Scholar 

  37. Sanford JA, Gallo RL. Functions of the skin microbiota in health and disease. Semin Immunol. 2013;25:370–7.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  38. Dréno B, Araviiskaia E, Berardesca E, Gontijo G, Sanchez Viera M, Xiang LF, et al. Microbiome in healthy skin, update for dermatologists. J Eur Acad Dermatol Venereol. 2016;30:2038–47.

    CrossRef  PubMed  PubMed Central  CAS  Google Scholar 

  39. Capone K. Intra and interpersonal changes in the skin microbiome from infancy to adulthood. Presented at 2013 AAP National Conference and Exhibition. Available at: https://aap.confex.com/aap/2013/webprogram/Paper21199.html.

  40. Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol. 2011;9:244–53.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  41. Schloss PD. An integrated view of the skin microbiome. Nature. 2014;514:44–5.

    CrossRef  CAS  PubMed  Google Scholar 

  42. Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC, et al. Topographical and temporal diversity of the human skin microbiome. Science. 2009;324:1190–2.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  43. Xu H, Li H. Acne, the skin microbiome, and antibiotic treatment. Am J Clin Dermatol. 2019;20(3):335–44. https://doi.org/10.1007/s40257-018-00417-3.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  44. Cosseau C, Romano-Bertrand S, Duplan H, Lucas O, Ingrassia I, Pigasse C, et al. Proteobacteria from the human skin microbiota: species-level diversity and hypotheses. One Health. 2016;2:33–41.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  45. Grice EA, Kong HH, Renaud G, Young AC, Bouffard GG, Blakesley RW, et al. A diversity profile of the human skin microbiota. Genome Res. 2008;18:1043–50.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  46. Hannigan GD, Meisel JS, Tyldsley AS, Zheng Q, Hodkinson BP, SanMiguel AJ, et al. The human skin double-stranded DNA virome: topographical and temporal diversity, genetic enrichment, and dynamic associations with the host microbiome. MBio. 2015;6:e01578–15.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  47. Hall JB, Cong Z, Imamura-Kawasawa Y, Kidd BA, Dudley JT, Thiboutot DM, et al. Isolation and identification of the follicular microbiome: implications for acne research. J Invest Dermatol. 2018;138:2033–40.

    CrossRef  CAS  PubMed  Google Scholar 

  48. Stacy A, Belkaid Y. Microbial guardians of skin health. Science. 2019;363:227–8.

    CrossRef  CAS  PubMed  Google Scholar 

  49. Cogen AL, Nizet V, Gallo RL. Skin microbiota: a source of disease or defence? Br J Dermatol. 2008;158:442–55.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  50. Shu M, Wang Y, Yu J, Kuo S, Coda A, Jiang Y, Gallo RL, Huang CM. Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus. PLoS One. 2013;8:e55380.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  51. Brandwein M, Steinberg D, Meshner S. Microbial biofilms and the human skin microbiome. NPJ Biofilms Microbiomes. 2016;2:3.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  52. Grice EA. The skin microbiome: potential for novel diagnostic and therapeutic approaches to cutaneous disease. Semin Cutan Med Surg. 2014;33:98–103.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  53. Fitz-Gibbon S, Tomida S, Chiu BH, Nguyen L, Du C, Liu M, et al. Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol. 2013;133:2152–60.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  54. Eady EA, Layton AM. A distinct acne microbiome: fact or fiction? J Invest Dermatol. 2013;133:2294–5.

    CrossRef  CAS  PubMed  Google Scholar 

  55. Bek-Thomsen M, Lomholt HB, Kilian M. Acne is not associated with yet-uncultured bacteria. J Clin Microbiol. 2008;46:3355–60.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  56. Chien AL, Tsai J, Leung S, Mongodin EF, Nelson AM, Kang S, et al. Association of systemic antibiotic treatment of acne with skin microbiota characteristics. JAMA Dermatol. 2019;155(4):425–34. https://doi.org/10.1001/jamadermatol.2018.5221.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  57. Kober MM, Bowe WP. The effect of probiotics on immune regulation, acne, and photoaging. Int J Womens Dermatol. 2015;1:85–9.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  58. Marzio LD, Di Marzio L, Cinque B, De Simone C, Grazia CM. Effect of the lactic acid bacterium streptococcus thermophilus on ceramide levels in human keratinocytes in vitro and stratum corneum in vivo. J Invest Dermatol. 1999;113:98–106.

    CrossRef  PubMed  Google Scholar 

  59. Dimarzio L, Cinque B, Cupelli F, De Simone C, Cifone MG. Giuliani MIncrease of skin-ceramide levels in aged subjects following a short-term topical application of bacterial sphingomyelinase from streptococcus thermophilus. Int J Immunopathol Pharmacol. 2008;21:137–43.

    CrossRef  CAS  Google Scholar 

  60. Pavicic T, Wollenweber U, Farwick M, Korting HC. Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris. Int J Cosmet Sci. 2007;29:181–90.

    CrossRef  CAS  PubMed  Google Scholar 

  61. Kang BS, Seo JG, Lee GS, Kim JH, Kim SY, Han YW, et al. Antimicrobial activity of Enterocins from enterococcus faecalis SL-5 against Propionibacterium acnes, the causative agent in acne vulgaris, and its therapeutic effect. J Microbiol. 2009;47:101–9.

    CrossRef  CAS  PubMed  Google Scholar 

  62. Al-Ghazzewi FH, Tester RF. Effect of konjac glucomannan hydrolysates and probiotics on the growth of the skin bacterium Propionibacterium acnes in vitro. Int J Cosmet Sci. 2010;32:139–42.

    CrossRef  CAS  PubMed  Google Scholar 

  63. Tavaria F. Topical use of probiotics: the natural balance. Porto Biomed J. 2017;2:69–70.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  64. Picardo M, Ottaviani M. Skin microbiome and skin disease: the example of rosacea. J Clin Gastroenterol. 2014;48(Suppl 1):S85–6.

    CrossRef  PubMed  Google Scholar 

  65. Casas C, Paul C, Lahfa M, Livideanu B, Lejeune O, Alvarez-Georges S, et al. Quantification of Demodex folliculorum by PCR in rosacea and its relationship to skin innate immune activation. Exp Dermatol. 2012;21:906–10.

    CrossRef  CAS  PubMed  Google Scholar 

  66. Georgala S, Katoulis AC, Kylafis GD, Koumantaki-Mathioudaki E, Georgala C, Aroni K. Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea. J Eur Acad Dermatol Venereol. 2001;15:441–4.

    CrossRef  CAS  PubMed  Google Scholar 

  67. Arck P, Handjiski B, Hagen E, Pincus M, Bruenahl C, Bienenstock J, et al. Is there a “gut-brain-skin axis”? Exp Dermatol. 2010;19:401–5.

    CrossRef  PubMed  Google Scholar 

  68. Dorrestein PC, Gallo RL, Knight R. Microbial skin inhabitants: friends forever. Cell. 2016;165:771–2.

    CrossRef  CAS  PubMed  Google Scholar 

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Correspondence to Jonette Keri .

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Fardin, S., Keri, J. (2021). The Microbiome, Probiotics, and Prebiotics. In: Rupani, R.N., Lio, P.A. (eds) Integrative Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-58954-7_1

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