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Integration of Matrisome Omics: Towards System Biology of the Tumor Matrisome

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Book cover Extracellular Matrix Omics

Part of the book series: Biology of Extracellular Matrix ((BEM,volume 7))

Abstract

The tumor matrisome, the collection of structural and functional extracellular matrix (ECM) proteins found in tumors together with ECM-associated proteins, growth factors, cytokines and chemokines is an extremely dynamic entity whose composition and regulation depends on both local, cell-specific processes and overarching pan-cancer microenvironmental landscapes. A deeper knowledge and understanding of the tumor matrisome would grant us novel diagnostic, prognostic and therapeutic possibilities but to reach that point there is a pressing need to combine fine-grained molecular studies with system biology approaches to build a complete map of what actually happens in the tumor microenvironment. In this chapter, we will review the most salient findings on the tumor matrisome at the transcriptomics, regulomics and proteomics level and show how the use of big data enables the identification of biological features and characteristics that cross different tumors and the discovery of novel molecular mechanisms connecting the different omics level. Also, we will provide a simple walkthrough to jumpstart matrisome data analysis for complete beginners in a bid to ignite more research in this fascinating field.

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Authors and Affiliations

  1. Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland

    Valerio Izzi, Jarkko Koivunen & Taina Pihlajaniemi

  2. Finnish Cancer Institute, Helsinki, Finland

    Valerio Izzi

  3. Department of Biochemistry, University of Turku, Turku, Finland

    Pekka Rappu & Jyrki Heino

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  1. Valerio Izzi
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  2. Jarkko Koivunen
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  5. Taina Pihlajaniemi
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  1. Institute of Molecular and Supramolecular Chemistry and Biochemistry (ICBMS), Université Claude Bernard Lyon 1, Villeurbanne Cedex, Lyon, France

    Sylvie Ricard-Blum

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Izzi, V., Koivunen, J., Rappu, P., Heino, J., Pihlajaniemi, T. (2020). Integration of Matrisome Omics: Towards System Biology of the Tumor Matrisome. In: Ricard-Blum, S. (eds) Extracellular Matrix Omics. Biology of Extracellular Matrix, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-030-58330-9_7

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