Abstract
The extracellular matrix (ECM) is the complex scaffold made of hundreds of proteins that governs the organization of cells and tissues in all multicellular organisms. It provides structural and mechanical properties to tissues. It also exerts signaling roles, either directly by interacting with cell surface receptors, or by interacting with growth factors and modulating their signaling activities, and by doing so regulates a multitude of cellular functions including cell-matrix interactions, cell proliferation, survival, and differentiation. The purpose of this introductory chapter is to present resources and tools developed to facilitate the identification and analysis of ECM genes and proteins across different conditions using high-throughput methodologies (i.e., genomics, transcriptomics, proteomics, and interactomics). Databases focused on specific ECM genes and ECM-related diseases including genetic diseases are highlighted in the second part of the chapter. The accessibility and standardization of -omic data are a prerequisite for the FAIR (Findability, Accessibility, Interoperability, and Reusability) guiding principles for scientific data management.
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References
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The authors would like to thank Martin Davis from the Naba lab for his critical reading of the manuscript.
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The work of the authors reported here was supported by a start-up fund from the Department of Physiology and Biophysics to and in part by a Catalyst Award from the Chicago Biomedical Consortium with support from the Searle Funds at the Chicago Community Trust (Grant C-088) to AN, and by the “Fondation pour la Recherche Médicale, France [grant number DBI20141231336 to SRB], the Institut Français de Bioinformatique [ANR-11-INBS-0013, Glycomatrix project, call 2015 to SRB], and the Groupement de Recherche (GDR) GagoSciences [CNRS, GDR 3739, Structure, Fonction et Régulation des Glycosaminoglycanes to SRB].
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Naba, A., Ricard-Blum, S. (2020). The Extracellular Matrix Goes -Omics: Resources and Tools. In: Ricard-Blum, S. (eds) Extracellular Matrix Omics. Biology of Extracellular Matrix, vol 7. Springer, Cham. https://doi.org/10.1007/978-3-030-58330-9_1
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DOI: https://doi.org/10.1007/978-3-030-58330-9_1
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