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Electrospun Nanofibers for Cancer Therapy

Chapter
First Online:
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1295)

Abstract

Lately, a remarkable progress has been recorded in the field of electrospinning for the preparation of numerous types of nanofiber scaffolds. These scaffolds present some remarkable features including high loading capacity and encapsulation efficiency, superficial area and porosity, potential for modification, structure for the co-delivery of various therapies, and cost-effectiveness. Their present and future applications for cancer diagnosis and treatment are promising and pioneering. In this chapter we provide a comprehensive overview of electrospun nanofibers (ESNFs) applications in cancer diagnosis and treatment, covering diverse types of drug-loaded electrospun nanofibers.

Keywords

Electrospun fibers Drug carrier Cancer diagnosis Cell capture Biosensors Chemosensors Gas sensors Immunosensor Intelligent cancer therapy Switchable drug release Immunotherapy Synergistic therapy 
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Notes

Acknowledgments

We thank Zhejiang Provincial Medical and Health Technology Foundation of China (2020RC125).

Notes

The authors declare no competing financial interest.

References

  1. 1.
    Qin, S. Y., Zhang, A. Q., Cheng, S. X., Rong, L., & Zhang, X. Z. (2017). Drug self-delivery systems for cancer therapy. Biomaterials, 112, 234–247.PubMedCrossRefPubMedCentralGoogle Scholar
  2. 2.
    Singh, M., Kundu, S., Reddy, M. A., Sreekanth, V., Motiani, R. K., Sengupta, S., Srivastava, A., & Bajaj, A. (2014). Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin. Nanoscale, 6(21), 12849–12855.PubMedCrossRefPubMedCentralGoogle Scholar
  3. 3.
    Cho, K., Wang, X., Nie, S., Chen, Z. G., & Shin, D. M. (2008). Therapeutic nanoparticles for drug delivery in cancer. Clinical Cancer Research, 14(5), 1310–1316.PubMedCrossRefPubMedCentralGoogle Scholar
  4. 4.
    Li, Y., Zhou, Y., Gu, T., Wang, G., Ren, Z., Weng, W., Li, X., Han, G., & Mao, C. (2016). A multifunctional Nanocrystalline CaF2:Tm,Yb@mSiO2 system for dual-triggered and optically monitored doxorubicin delivery. Particle and Particle Systems Characterization, 33(12), 896–905.PubMedCrossRefPubMedCentralGoogle Scholar
  5. 5.
    Li, Y., Zhou, Y., Li, X., Sun, J., Ren, Z., Wen, W., Yang, X., & Han, G. (2016). A facile approach to Upconversion crystalline CaF2:Yb(3+),Tm(3+)@mSiO2 nanospheres for tumor therapy. RSC Advances, 6(44), 38365–38370.PubMedPubMedCentralCrossRefGoogle Scholar
  6. 6.
    Li, Z., Hu, Y., Howard, K. A., Jiang, T., Fan, X., Miao, Z., Sun, Y., Besenbacher, F., & Yu, M. (2016). Multifunctional bismuth selenide nanocomposites for antitumor thermo-chemotherapy and imaging. ACS Nano, 10(1), 984–997.PubMedCrossRefPubMedCentralGoogle Scholar
  7. 7.
    Li, W., Peng, J., Tan, L., Wu, J., Shi, K., Qu, Y., Wei, X., & Qian, Z. (2016). Mild photothermal therapy/photodynamic therapy/chemotherapy of breast cancer by Lyp-1 modified Docetaxel/IR820 Co-loaded micelles. Biomaterials, 106, 119–133.PubMedCrossRefPubMedCentralGoogle Scholar
  8. 8.
    Zhang, Q., Polyakov, N., Chistyachenko, Y., Khvostov, M., Frolova, T., Tolstikova, T., Alexandr, D., & Su, W. (2018). Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry. Drug Delivery, 25, 198–209.PubMedPubMedCentralCrossRefGoogle Scholar
  9. 9.
    Xiang, J., Wu, B., Zhou, Z., Hu, S., Piao, Y., Zhou, Q., Wang, G., Tang, J., Liu, X., & Shen, Y. (2018). Synthesis and evaluation of a paclitaxel-binding polymeric micelle for efficient breast cancer therapy. Science China Life Sciences, 61, 436.PubMedCrossRefPubMedCentralGoogle Scholar
  10. 10.
    Feng, L., Gao, M., Tao, D., Chen, Q., Wang, H., Dong, Z., Chen, M., & Liu, Z. (2016). Cisplatin-prodrug-constructed liposomes as a versatile theranostic nanoplatform for bimodal imaging guided combination cancer therapy. Advanced Functional Materials, 26, 2207–2217.CrossRefGoogle Scholar
  11. 11.
    Ngweniform, P., Abbineni, G., Cao, B., & Mao, C. (2009). Self-assembly of drug-loaded liposomes on genetically engineered target-recognizing M13 phage: A novel nanocarrier for targeted drug delivery. Small, 5(17), 1963–1969.PubMedCrossRefPubMedCentralGoogle Scholar
  12. 12.
    Fang, J., Nakamura, H., & Maeda, H. (2011). The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Advanced Drug Delivery Reviews, 63(3), 136–151.PubMedCrossRefPubMedCentralGoogle Scholar
  13. 13.
    Huynh, E., & Zheng, G. (2015). Cancer nanomedicine: Addressing the dark side of the enhanced permeability and retention effect. Nanomedicine, 10(13), 1993–1995.PubMedCrossRefPubMedCentralGoogle Scholar
  14. 14.
    Jain, R. K., & Stylianopoulos, T. (2010). Delivering nanomedicine to solid tumors. Nature Reviews. Clinical Oncology, 7(11), 653–664.PubMedPubMedCentralCrossRefGoogle Scholar
  15. 15.
    Soussan, E., Cassel, S., Blanzat, M., & Rico-Lattes, I. (2009). Drug delivery by soft matter: Matrix and vesicular carriers. Angewandte Chemie (International Ed. in English), 48(2), 274–288.CrossRefGoogle Scholar
  16. 16.
    Fu, Y., Chen, X., Mou, X., Ren, Z., Li, X., & Han, G. (2016). A dual-color luminescent localized drug delivery system with ratiometric-monitored doxorubicin release functionalities. ACS Biomaterials Science & Engineering, 2(4), 652–661.CrossRefGoogle Scholar
  17. 17.
    Huang, S., Duan, S., Wang, J., Bao, S., Qiu, X., Li, C., Liu, Y., Yan, L., Zhang, Z., & Hu, Y. (2016). Folic-acid-mediated functionalized gold nanocages for targeted delivery of anti-miR-181b in combination of gene therapy and photothermal therapy against hepatocellular carcinoma. Advanced Functional Materials, 26(15), 2532–2544.CrossRefGoogle Scholar
  18. 18.
    Folkman, J., & Long, D. (1964). The use of silicone rubber as a carrier for prolonged drug therapy. Journal of Surgical Research, 4(3), 139–142.CrossRefGoogle Scholar
  19. 19.
    De Souza, R., Zahedi, P., Allen, C. J., & Piquette-Miller, M. (2010). Polymeric drug delivery systems for localized cancer chemotherapy. Drug Delivery, 17(6), 365–375.PubMedCrossRefPubMedCentralGoogle Scholar
  20. 20.
    Ho, E. A., Soo, P. L., Allen, C., & Piquette-Miller, M. (2007). Impact of intraperitoneal, sustained delivery of paclitaxel on the expression of P-glycoprotein in ovarian tumors. Journal of Controlled Release, 117(1), 20–27.PubMedCrossRefPubMedCentralGoogle Scholar
  21. 21.
    Wolinsky, J. B., Colson, Y. L., & Grinstaff, M. W. (2012). Local drug delivery strategies for cancer treatment: Gels, nanoparticles, polymeric films, rods, and wafers. Journal of Controlled Release, 159(1), 14–26.PubMedCrossRefPubMedCentralGoogle Scholar
  22. 22.
    Xue, J., Xie, J., Liu, W., & Xia, Y. (2017). Electrospun nanofibers: New concepts, materials, and applications. Accounts of Chemical Research, 50(8), 1976–1987.PubMedPubMedCentralCrossRefGoogle Scholar
  23. 23.
    Nair, L. S., Bhattacharyya, S., & Laurencin, C. T. (2004). Development of novel tissue engineering scaffolds via electrospinning. Expert Opinion on Biological Therapy, 4(5), 659–668.PubMedCrossRefPubMedCentralGoogle Scholar
  24. 24.
    Goyal, R., Macri, L. K., Kaplan, H. M., & Kohn, J. (2016). Nanoparticles and nanofibers for topical drug delivery. Journal of Controlled Release, 240, 77–92.PubMedCrossRefPubMedCentralGoogle Scholar
  25. 25.
    Jiang, S., Lv, L. P., Landfester, K., & Crespy, D. (2016). Nanocontainers in and onto nanofibers. Accounts of Chemical Research, 49(5), 816–823.PubMedCrossRefPubMedCentralGoogle Scholar
  26. 26.
    Aussawasathien, D., Teerawattananon, C., & Vongachariya, A. (2008). Separation of micron to sub-micron particles from water: Electrospun nylon-6 nanofibrous membranes as pre-filters. Journal of Membrane Science, 315(1–2), 11–19.CrossRefGoogle Scholar
  27. 27.
    Gopal, R., Kaur, S., Feng, C. Y., Chan, C., Ramakrishna, S., Tabe, S., & Matsuura, T. (2007). Electrospun nanofibrous polysulfone membranes as pre-filters: Particulate removal. Journal of Membrane Science, 289(1–2), 210–219.CrossRefGoogle Scholar
  28. 28.
    Gopal, R., Kaur, S., Ma, Z., Chan, C., Ramakrishna, S., & Matsuura, T. (2006). Electrospun nanofibrous filtration membrane. Journal of Membrane Science, 281(1–2), 581–586.CrossRefGoogle Scholar
  29. 29.
    Gorji, M., Jeddi, A. A. A., & Gharehaghaji, A. A. (2012). Fabrication and characterization of polyurethane electrospun nanofiber membranes for protective clothing applications. Journal of Applied Polymer Science, 125(5), 4135–4141.CrossRefGoogle Scholar
  30. 30.
    Lee, S., & Kay Obendorf, S. (2006). Developing protective textile materials as barriers to liquid penetration using melt-electrospinning. Journal of Applied Polymer Science, 102(4), 3430–3437.CrossRefGoogle Scholar
  31. 31.
    Kowalczyk, T., Nowicka, A., Elbaum, D., & Kowalewski, T. A. (2008). Electrospinning of bovine serum albumin. Optimization and the use for production of biosensors. Biomacromolecules, 9(7), 2087–2090.PubMedCrossRefPubMedCentralGoogle Scholar
  32. 32.
    Rojas, R., & Pinto, N. J. (2008). Using electrospinning for the fabrication of rapid response gas sensors based on conducting polymer nanowires. IEEE Sensors Journal, 8(6), 951–953.CrossRefGoogle Scholar
  33. 33.
    Dong, Z., Kennedy, S. J., & Wu, Y. (2011). Electrospinning materials for energy-related applications and devices. Journal of Power Sources, 196(11), 4886–4904.CrossRefGoogle Scholar
  34. 34.
    Khil, M., Chan, D., Kim, H., Kim, I., & Bhattarai, N. (2003). Electrospun nanofibrous polyurethane membrane as wound dressing. Journal of Biomedical Materials Research, 67B(2), 675–679.CrossRefGoogle Scholar
  35. 35.
    Luo, C. J., Stoyanov, S. D., Stride, E., Pelan, E., & Edirisinghe, M. (2012). Electrospinning versus fibre production methods: From specifics to technological convergence. Chemical Society Reviews, 41(13), 4708–4735.PubMedCrossRefPubMedCentralGoogle Scholar
  36. 36.
    Persano, L., Camposeo, A., Tekmen, C., & Pisignano, D. (2013). Industrial upscaling of electrospinning and applications of polymer nanofibers: A review. Macromolecular Materials and Engineering, 298(5), 504–520.CrossRefGoogle Scholar
  37. 37.
    Zahedi, P., Rezaeian, I., Ranaei-Siadat, S.-O., Jafari, S.-H., & Supaphol, P. (2009., , n/a–n/a). A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polymers for Advanced Technologies.Google Scholar
  38. 38.
    Zhou, F.-L., Gong, R.-H., & Porat, I. (2009). Mass production of nanofibre assemblies by electrostatic spinning. Polymer International, 58(4), 331–342.CrossRefGoogle Scholar
  39. 39.
    Pillay, V., Dott, C., Choonara, Y. E., Tyagi, C., Tomar, L., Kumar, P., du Toit, L. C., & Ndesendo, V. M. K. (2013). A review of the effect of processing variables on the fabrication of electrospun nanofibers for drug delivery applications. Journal of Nanomaterials, 2013, 1–22.CrossRefGoogle Scholar
  40. 40.
    Rieger, K. A., Birch, N. P., & Schiffman, J. D. (2013). Designing electrospun nanofiber mats to promote wound healing – A review. Journal of Materials Chemistry B, 1(36), 4531.PubMedCrossRefPubMedCentralGoogle Scholar
  41. 41.
    Sill, T. J., & von Recum, H. A. (2008). Electrospinning: Applications in drug delivery and tissue engineering. Biomaterials, 29(13), 1989–2006.PubMedCrossRefPubMedCentralGoogle Scholar
  42. 42.
    Yoo, H. S., Kim, T. G., & Park, T. G. (2009). Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Advanced Drug Delivery Reviews, 61(12), 1033–1042.PubMedCrossRefPubMedCentralGoogle Scholar
  43. 43.
    Kenawy, E. R., Bowlin, G. L., Mansfield, K., Layman, J., Simpson, D. G., Sanders, E. H., & Wnek, G. E. (2002). Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinyl acetate), poly(lactic acid), and a blend. Journal of Controlled Release, 81, 57–64.CrossRefGoogle Scholar
  44. 44.
    Bala Balakrishnan, P., Gardella, L., Forouharshad, M., Pellegrino, T., & Monticelli, O. (2018). Star poly(ε-caprolactone)-based electrospun fibers as biocompatible scaffold for doxorubicin with prolonged drug release activity. Colloids and Surfaces B: Biointerfaces, 161, 488–496.PubMedCrossRefPubMedCentralGoogle Scholar
  45. 45.
    Gabriel, D., Cohen-Karni, T., Huang, D., Chiang, H. H., & Kohane, D. S. (2014). Photoactive electrospun fibers for inducing cell death. Advanced Healthcare Materials, 3(4), 494–499.PubMedCrossRefPubMedCentralGoogle Scholar
  46. 46.
    Mohammadian, F., & Eatemadi, A. (2017). Drug loading and delivery using nanofibers scaffolds. Artificial Cells, Nanomedicine, and Biotechnology, 45(5), 881–888.PubMedCrossRefPubMedCentralGoogle Scholar
  47. 47.
    Zeng, J., Xu, X., Chen, X., Liang, Q., Bian, X., Yang, L., & Jing, X. (2003). Biodegradable electrospun fibers for drug delivery. Journal of Controlled Release, 92(3), 227–231.PubMedCrossRefPubMedCentralGoogle Scholar
  48. 48.
    Zeng, J., Yang, L., Liang, Q., Zhang, X., Guan, H., Xu, X., Chen, X., & Jing, X. (2005). Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation. Journal of Controlled Release, 105(1–2), 43–51.PubMedCrossRefPubMedCentralGoogle Scholar
  49. 49.
    Xu, X., Yang, L., Xu, X., Wang, X., Chen, X., Liang, Q., Zeng, J., & Jing, X. (2005). Ultrafine medicated fibers electrospun from W/O emulsions. Journal of Controlled Release, 108(1), 33–42.PubMedCrossRefPubMedCentralGoogle Scholar
  50. 50.
    Loo, T. L., Dion, R. L., Dixon, R. L., & Rall, D. P. (1966). The antitumor agent, 1,3-bis(2-chloroethyl)-1-nitrosourea. Journal of Pharmaceutical Sciences, 55(5), 492–497.CrossRefGoogle Scholar
  51. 51.
    Xu, X., Chen, X., Xu, X., Lu, T., Wang, X., Yang, L., & Jing, X. (2006). BCNU-loaded PEG-PLLA ultrafine fibers and their in vitro antitumor activity against Glioma C6 cells. Journal of Controlled Release, 114(3), 307–316.PubMedCrossRefPubMedCentralGoogle Scholar
  52. 52.
    Liu, D., Liu, S., Jing, X., Li, X., Li, W., & Huang, Y. (2012). Necrosis of cervical carcinoma by dichloroacetate released from electrospun polylactide mats. Biomaterials, 33(17), 4362–4369.PubMedCrossRefPubMedCentralGoogle Scholar
  53. 53.
    Ma, G., Liu, Y., Peng, C., Fang, D., He, B., & Nie, J. (2011). Paclitaxel loaded electrospun porous nanofibers as mat potential application for chemotherapy against prostate cancer. Carbohydrate Polymers, 86(2), 505–512.CrossRefGoogle Scholar
  54. 54.
    Shao, S., Li, L., Yang, G., Li, J., Luo, C., Gong, T., & Zhou, S. (2011). Controlled green tea polyphenols release from electrospun PCL/MWCNTs composite nanofibers. International Journal of Pharmaceutics, 421(2), 310–320.PubMedCrossRefPubMedCentralGoogle Scholar
  55. 55.
    Chen, F. M., Zhang, M., & Wu, Z. F. (2010). Toward delivery of multiple growth factors in tissue engineering. Biomaterials, 31(24), 6279–6308.PubMedCrossRefPubMedCentralGoogle Scholar
  56. 56.
    Xie, C., Li, X., Luo, X., Yang, Y., Cui, W., Zou, J., & Zhou, S. (2010). Release modulation and cytotoxicity of hydroxycamptothecin-loaded electrospun fibers with 2-hydroxypropyl-beta-cyclodextrin inoculations. International Journal of Pharmaceutics, 391(1–2), 55–64.PubMedCrossRefPubMedCentralGoogle Scholar
  57. 57.
    Mi, K., & Xing, Z. (2015). CD44(+)/CD24(−) breast cancer cells exhibit phenotypic reversion in three-dimensional self-assembling peptide RADA16 nanofiber scaffold. International Journal of Nanomedicine, 10, 3043–3053.PubMedPubMedCentralCrossRefGoogle Scholar
  58. 58.
    Liu, S., Wang, X., Zhang, Z., Zhang, Y., Zhou, G., Huang, Y., Xie, Z., & Jing, X. (2015). Use of asymmetric multilayer polylactide nanofiber mats in controlled release of drugs and prevention of liver cancer recurrence after surgery in mice. Nanomedicine, 11(5), 1047–1056.PubMedCrossRefPubMedCentralGoogle Scholar
  59. 59.
    Yang, G., Wang, J., Wang, Y., Li, L., Guo, X., & Zhou, S. (2015). An implantable active-targeting micelle-in-nanofiber device for efficient and safe cancer therapy. ACS Nano, 9(2), 1161–1174.PubMedCrossRefPubMedCentralGoogle Scholar
  60. 60.
    Zamani, M., Prabhakaran, M. P., & Ramakrishna, S. (2013). Advances in drug delivery via electrospun and electrosprayed nanomaterials. International Journal of Nanomedicine, 8, 2997–3017.PubMedPubMedCentralGoogle Scholar
  61. 61.
    Kim, Y.-J., ebara, m., & Aoyagi, T. (2013). A smart hyperthermia nanofiber with switchable drug release for inducing cancer apoptosis. Advanced Functional Materials, 23, 5753–5761.CrossRefGoogle Scholar
  62. 62.
    Liang, P., Zheng, J., Dai, S., Wang, J., Zhang, Z., Kang, T., & Quan, C. (2017). pH triggered re-assembly of nanosphere to nanofiber: The role of peptide conformational change for enhanced cancer therapy. Journal of Controlled Release, 260, 22–31.PubMedCrossRefPubMedCentralGoogle Scholar
  63. 63.
    Sadrearhami, Z., Morshed, M., & Varshosaz, J. (2015). Production and evaluation of polyblend of Agar and polyacrylonitrile nanofibers for in vitro release of methotrexate in cancer therapy. Fibers and Polymers, 16, 254–262.CrossRefGoogle Scholar
  64. 64.
    Kim, Y.-J., Park, M., Kim, M., & Kwon, O. H. (2012). Polyphenol-loaded polycaprolactone nanofibers for effective growth inhibition of human cancer cells. Materials Chemistry and Physics, 133, 674–680.CrossRefGoogle Scholar
  65. 65.
    Chou, S.-F., Carson, D., & Woodrow, K. A. (2015). Current strategies for sustaining drug release from electrospun nanofibers. Journal of Controlled Release, 220, 584–591.PubMedPubMedCentralCrossRefGoogle Scholar
  66. 66.
    Carson, D., Jiang, Y., & Woodrow, K. A. (2016). Tunable release of multiclass anti-HIV drugs that are water-soluble and loaded at high drug content in polyester blended electrospun fibers. Pharmaceutical Research, 33(1), 125–136.PubMedCrossRefPubMedCentralGoogle Scholar
  67. 67.
    Xie, J., & Wang, C. H. (2006). Electrospun micro- and nanofibers for sustained delivery of paclitaxel to treat C6 glioma in vitro. Pharmaceutical Research, 23(8), 1817–1826.PubMedCrossRefPubMedCentralGoogle Scholar
  68. 68.
    McDonald, P. F., Lyons, J. G., Geever, L. M., & Higginbotham, C. L. (2010). In vitro degradation and drug release from polymer blends based on poly(dl-lactide), poly(l-lactide-glycolide) and poly(ε-caprolactone). Journal of Materials Science, 45(5), 1284–1292.CrossRefGoogle Scholar
  69. 69.
    He, C. L., Huang, Z. M., Han, X. J., Liu, L., Zhang, H. S., & Chen, L. S. (2006). Coaxial electrospun poly(L-lactic acid) ultrafine fibers for sustained drug delivery. Journal of Macromolecular Science, Part B, 45(4), 515–524.CrossRefGoogle Scholar
  70. 70.
    Reise, M., Wyrwa, R., Muller, U., Zylinski, M., Volpel, A., Schnabelrauch, M., Berg, A., Jandt, K. D., Watts, D. C., & Sigusch, B. W. (2012). Release of metronidazole from electrospun poly(L-lactide-co-D/L-lactide) fibers for local periodontitis treatment. Dental Materials, 28(2), 179–188.PubMedCrossRefPubMedCentralGoogle Scholar
  71. 71.
    Verreck, G., Chun, I., Rosenblatt, J., Peeters, J., Dijck, A. V., Mensch, J., Noppe, M., & Brewster, M. E. (2003). Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer. Journal of Controlled Release, 92(3), 349–360.PubMedCrossRefPubMedCentralGoogle Scholar
  72. 72.
    Llorens, E., Ibanez, H., Del Valle, L. J., & Puiggali, J. (2015). Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol. Materials Science & Engineering. C, Materials for Biological Applications, 49, 472–484.CrossRefGoogle Scholar
  73. 73.
    Yang, J. M., Zha, L. S., Yu, D. G., & Liu, J. (2013). Coaxial electrospinning with acetic acid for preparing ferulic acid/zein composite fibers with improved drug release profiles. Colloids and Surfaces. B, Biointerfaces, 102, 737–743.PubMedCrossRefPubMedCentralGoogle Scholar
  74. 74.
    He, M., Xue, J., Geng, H., Gu, H., Chen, D., Shi, R., & Zhang, L. (2015). Fibrous guided tissue regeneration membrane loaded with anti-inflammatory agent prepared by coaxial electrospinning for the purpose of controlled release. Applied Surface Science, 335, 121–129.CrossRefGoogle Scholar
  75. 75.
    Tiwari, S. K., Tzezana, R., Zussman, E., & Venkatraman, S. S. (2010). Optimizing partition-controlled drug release from electrospun core-shell fibers. International Journal of Pharmaceutics, 392(1–2), 209–217.PubMedCrossRefPubMedCentralGoogle Scholar
  76. 76.
    Yu, H., Jia, Y., Yao, C., & Lu, Y. (2014). PCL/PEG core/sheath fibers with controlled drug release rate fabricated on the basis of a novel combined technique. International Journal of Pharmaceutics, 469(1), 17–22.PubMedCrossRefPubMedCentralGoogle Scholar
  77. 77.
    Kiatyongchai, T., Wongsasulak, S., & Yoovidhya, T. (2014). Coaxial electrospinning and release characteristics of cellulose acetate-gelatin blend encapsulating a model drug. Journal of Applied Polymer Science, 131(8), n/a–n/a.CrossRefGoogle Scholar
  78. 78.
    Sohrabi, A., Shaibani, P. M., Etayash, H., Kaur, K., & Thundat, T. (2013). Sustained drug release and antibacterial activity of ampicillin incorporated poly(methyl methacrylate)–nylon6 core/shell nanofibers. Polymer, 54(11), 2699–2705.CrossRefGoogle Scholar
  79. 79.
    Ball, C., Krogstad, E., Chaowanachan, T., & Woodrow, K. A. (2012). Drug-eluting fibers for HIV-1 inhibition and contraception. PLoS One, 7(11), e49792.PubMedPubMedCentralCrossRefGoogle Scholar
  80. 80.
    Huang, C., Soenen, S. J., van Gulck, E., Vanham, G., Rejman, J., Van Calenbergh, S., Vervaet, C., Coenye, T., Verstraelen, H., Temmerman, M., et al. (2012). Electrospun cellulose acetate phthalate fibers for semen induced anti-HIV vaginal drug delivery. Biomaterials, 33(3), 962–969.PubMedCrossRefPubMedCentralGoogle Scholar
  81. 81.
    Varkey, M., Gittens, S. A., & Uludag, H. (2004). Growth factor delivery for bone tissue repair: An update. Expert Opinion Drug Delivery, 1(1), 19–36.CrossRefGoogle Scholar
  82. 82.
    Chen, P., Wu, Q. S., Ding, Y. P., Chu, M., Huang, Z. M., & Hu, W. (2010). A controlled release system of titanocene dichloride by electrospun fiber and its antitumor activity in vitro. European Journal of Pharmaceutics and Biopharmaceutics, 76(3), 413–420.PubMedCrossRefPubMedCentralGoogle Scholar
  83. 83.
    Chew, S. Y., Wen, J., Yim, E., & Leong, K. W. (2005). Sustained release of proteins from electrospun biodegradable fibers. Biomacromolecules, 6, 2017–2024.PubMedCrossRefPubMedCentralGoogle Scholar
  84. 84.
    Patel, S., Kurpinski, K., Quigley, R., Gao, H., Hsiao, B. S., Poo, M., & Li, S. (2007). Bioactive nanofibers-synergistic effects of nanotopography and chemical signaling on cell guidance. Nano Letters, 7(7), 2122–2128.PubMedCrossRefPubMedCentralGoogle Scholar
  85. 85.
    Sahoo, S., Ang, L. T., Goh, J. C., & Toh, S. L. (2010). Growth factor delivery through electrospun nanofibers in scaffolds for tissue engineering applications. Journal of Biomedical Materials Research. Part A, 93(4), 1539–1550.PubMedPubMedCentralGoogle Scholar
  86. 86.
    Mottaghitalab, F., Farokhi, M., Mottaghitalab, V., Ziabari, M., Divsalar, A., & Shokrgozar, M. A. (2011). Enhancement of neural cell lines proliferation using nano-structured chitosan/poly(vinyl alcohol) scaffolds conjugated with nerve growth factor. Carbohydrate Polymers, 86(2), 526–535.CrossRefGoogle Scholar
  87. 87.
    Zomer Volpato, F., Almodovar, J., Erickson, K., Popat, K. C., Migliaresi, C., & Kipper, M. J. (2012). Preservation of FGF-2 bioactivity using heparin-based nanoparticles, and their delivery from electrospun chitosan fibers. Acta Biomaterialia, 8(4), 1551–1559.PubMedCrossRefPubMedCentralGoogle Scholar
  88. 88.
    Liao, I. C., Chen, S., Liu, J., & Leong, K. (2009). Sustained viral gene delivery through core-shell fibers. Journal of Controlled Release: Official Journal of the Controlled Release Society, 139, 48–55.CrossRefGoogle Scholar
  89. 89.
    Wang, J., An, Q., Li, D., Wu, T., Chen, W., Sun, B., El-Hamshary, H., Al-Deyab, S. S., Zhu, W., & Mo, X. (2015). Heparin and vascular endothelial growth factor loaded poly(L-lactide-co-caprolactone) nanofiber covered stent-graft for aneurysm treatment. Journal of Biomedical Nanotechnology, 11(11), 1947–1960.PubMedCrossRefPubMedCentralGoogle Scholar
  90. 90.
    Yu, Y. Q., Jiang, X. S., Gao, S., Ma, R., Jin, Y., Jin, X., Peng, S. Y., Mao, H. Q., & Li, J. T. (2014). Local delivery of vascular endothelial growth factor via nanofiber matrix improves liver regeneration after extensive hepatectomy in rats. Journal of Biomedical Nanotechnology, 10(11), 3407–3415.PubMedCrossRefPubMedCentralGoogle Scholar
  91. 91.
    Kim, T. H., Kim, J. J., & Kim, H. W. (2014). Basic fibroblast growth factor-loaded, mineralized biopolymer-nanofiber scaffold improves adhesion and proliferation of rat mesenchymal stem cells. Biotechnology Letters, 36(2), 383–390.PubMedCrossRefPubMedCentralGoogle Scholar
  92. 92.
    Jain, V., Jain, S., & Mahajan, S. (2015). Nanomedicines based drug delivery systems for anti-cancer targeting and treatment. Current Drug Delivery, 12(2), 177–191.PubMedCrossRefPubMedCentralGoogle Scholar
  93. 93.
    Maitra, A., Arking, D. E., Shivapurkar, N., Ikeda, M., Stastny, V., Kassauei, K., Sui, G., Cutler, D. J., Liu, Y., Brimble, S. N., et al. (2005). Genomic alterations in cultured human embryonic stem cells. Nature Genetics, 37(10), 1099–1103.PubMedCrossRefPubMedCentralGoogle Scholar
  94. 94.
    Lai, K., Kaspar, B., Gage, F., & Schaffer, D. (2003). Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo. Nature Neuroscience, 6, 21–27.PubMedCrossRefPubMedCentralGoogle Scholar
  95. 95.
    Gropp, M., Itsykson, P., Singer, O., Ben-Hur, T., Reinhartz, E., Galun, E., & Reubinoff, B. E. (2003). Stable genetic modification of human embryonic stem cells by lentiviral vectors. Molecular Therapy, 7(2), 281–287.PubMedCrossRefPubMedCentralGoogle Scholar
  96. 96.
    Walther, W., & Schlag, P. (2013). Current status of gene therapy for cancer. Current Opinion in Oncology, 25, 659–664.PubMedCrossRefPubMedCentralGoogle Scholar
  97. 97.
    Réjiba, S., Bigand, C., Parmentier, C., Masmoudi, A., & Hajri, A. (2013). Oncosuppressive suicide gene Virotherapy “PVH1-yCD/5-FC” for pancreatic peritoneal carcinomatosis treatment: NFκB and Akt/PI3K involvement. PLoS One, 8, e70594.PubMedPubMedCentralCrossRefGoogle Scholar
  98. 98.
    Jang, J.-H., Houchin, T., Shea, L., Jang, J. H., Houchin, T. L., & Shea, L. D. (2004). Gene delivery from polymer scaffolds for tissue engineering. Expert Review of Medical Devices, 1, 127–138.PubMedCrossRefPubMedCentralGoogle Scholar
  99. 99.
    Shea, L., Smiley, E., Bonadio, J., Mooney, D., Shea, L. D., Smiley, E., Bonadio, J., & Mooney, D. J. (1999). DNA delivery from polymer matrices for tissue engineering. Nature Biotechnology, 17, 551–554.PubMedCrossRefPubMedCentralGoogle Scholar
  100. 100.
    Yates, F., Daley, G., Yates, F., & Daley, G. Q. (2006). Progress and prospects: Gene transfer into embryonic stem cells. Gene Therapy, 13, 1431–1439.PubMedCrossRefPubMedCentralGoogle Scholar
  101. 101.
    Hanna, E., Remuzat, C., Auquier, P., & Toumi, M. (2017). Gene therapies development: Slow progress and promising prospect. Journal of Market Access Health Policy, 5(1), 1265293.PubMedPubMedCentralCrossRefGoogle Scholar
  102. 102.
    Nayerossadat, N., Maedeh, T., & Ali, P. A. (2012). Viral and nonviral delivery systems for gene delivery. Advanced Biomedical Research, 1, 27.PubMedPubMedCentralCrossRefGoogle Scholar
  103. 103.
    Cao, H., Jiang, X., Chai, C., & Chew, S. Y. (2010). RNA interference by nanofiber-based siRNA delivery system. Journal of Controlled Release, 144(2), 203–212.PubMedCrossRefPubMedCentralGoogle Scholar
  104. 104.
    Chen, M., Gao, S., Dong, M., Song, J., Yang, C., Howard, H. A., Kjems, K., & Besenbacher, F. (2012). Chitosan-siRNA nanoparticles encapsulated in PLGA nanofibers for siRNA delivery. ACS Nano, 6(6), 4835–4844.PubMedCrossRefPubMedCentralGoogle Scholar
  105. 105.
    Chooi, W. H., Ong, W., Murray, A., Lin, J., Nizetic, D., & Chew, S. Y. (2018). Scaffold mediated gene knockdown for neuronal differentiation of human neural progenitor cells. Biomaterials Science, 6(11), 3019–3029.PubMedCrossRefPubMedCentralGoogle Scholar
  106. 106.
    He, S., Xia, T., Wang, H., Wei, L., Luo, X., & Li, X. (2012). Multiple release of polyplexes of plasmids VEGF and bFGF from electrospun fibrous scaffolds towards regeneration of mature blood vessels. Acta Biomaterialia, 8(7), 2659–2669.PubMedCrossRefPubMedCentralGoogle Scholar
  107. 107.
    Hu, W. W., & Ting, J. C. (2019). Gene immobilization on alginate/polycaprolactone fibers through electrophoretic deposition to promote in situ transfection efficiency and biocompatibility. International Journal of Biological Macromolecules, 121, 1337–1345.PubMedCrossRefPubMedCentralGoogle Scholar
  108. 108.
    Karthikeyan, K., Krishnaswamy, V. R., Lakra, R., Kiran, M. S., & Korrapati, P. S. (2015). Fabrication of electrospun zein nanofibers for the sustained delivery of siRNA. Journal of Materials Science. Materials in Medicine, 26(2), 101.PubMedCrossRefPubMedCentralGoogle Scholar
  109. 109.
    Kim, H. S., & Yoo, H. S. (2010). MMPs-responsive release of DNA from electrospun nanofibrous matrix for local gene therapy: In vitro and in vivo evaluation. Journal of Controlled Release, 145(3), 264–271.PubMedCrossRefPubMedCentralGoogle Scholar
  110. 110.
    Kim, H. S., & Yoo, H. S. (2013). Matrix metalloproteinase-inspired suicidal treatments of diabetic ulcers with siRNA-decorated nanofibrous meshes. Gene Therapy, 20(4), 378–385.PubMedCrossRefPubMedCentralGoogle Scholar
  111. 111.
    Lee, S., Kim, J. S., Chu, H. S., Kim, G. W., Won, J. I., & Jang, J. H. (2011). Electrospun nanofibrous scaffolds for controlled release of adeno-associated viral vectors. Acta Biomaterialia, 7(11), 3868–3876.PubMedCrossRefPubMedCentralGoogle Scholar
  112. 112.
    Liang, D., Luu, Y., Kim, K., Hsiao, B., Hadjiargyrou, M., & Chu, B. (2005). In vitro non-viral gene delivery with nanofibrous scaffolds. Nucleic Acids Research, 33, e170.PubMedPubMedCentralCrossRefGoogle Scholar
  113. 113.
    Low, W. C., Rujitanaroj, P. O., Lee, D. K., Kuang, J., Messersmith, P. B., Chan, J. K., & Chew, S. Y. (2015). Mussel-inspired modification of nanofibers for REST siRNA delivery: Understanding the effects of gene-silencing and substrate topography on human mesenchymal stem cell neuronal commitment. Macromolecular Bioscience, 15(10), 1457–1468.PubMedCrossRefPubMedCentralGoogle Scholar
  114. 114.
    Low, W. C., Rujitanaroj, P. O., Lee, D. K., Messersmith, P. B., Stanton, L. W., Goh, E., & Chew, S. Y. (2013). Nanofibrous scaffold-mediated REST knockdown to enhance neuronal differentiation of stem cells. Biomaterials, 34(14), 3581–3590.PubMedCrossRefPubMedCentralGoogle Scholar
  115. 115.
    Luu, Y. K., Kim, K., Hsiao, B. S., Chu, B., & Hadjiargyrou, M. (2003). Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA–PEG block copolymers. Journal of Controlled Release, 89(2), 341–353.PubMedCrossRefPubMedCentralGoogle Scholar
  116. 116.
    Mazza, M., Hadjidemetriou, M., La’zaro, I., Bussy, C., & Kostarelos, K. (2015). Peptide nanofiber complexes with siRNA for deep brain gene silencing by stereotactic neurosurgery. ACS Nano, 9(2), 1137–1149.PubMedCrossRefPubMedCentralGoogle Scholar
  117. 117.
    Nie, H., Ho, M. L., Wang, C. K., Wang, C. H., & Fu, Y. C. (2009). BMP-2 plasmid loaded PLGA/HAp composite scaffolds for treatment of bone defects in nude mice. Biomaterials, 30(5), 892–901.PubMedCrossRefPubMedCentralGoogle Scholar
  118. 118.
    Nie, H., & Wang, C.-H. (2007). Fabrication and characterization of PLGA/HAp composite scaffolds for delivery of BMP-2 plasmid DNA. Journal of Controlled Release, 120(1), 111–121.PubMedCrossRefPubMedCentralGoogle Scholar
  119. 119.
    Pinese, C., Lin, J., Milbreta, U., Li, M., Wang, Y., Leong, K. W., & Chew, S. Y. (2018). Sustained delivery of siRNA/mesoporous silica nanoparticle complexes from nanofiber scaffolds for long-term gene silencing. Acta Biomaterialia, 76, 164–177.PubMedCrossRefPubMedCentralGoogle Scholar
  120. 120.
    Qin, L., Yan, P., Xie, C., Huang, J., Ren, Z., Li, X., Best, S., Cai, X., & Han, G. (2018). Gold nanorod-assembled ZnGa2O4:Cr nanofibers for LED-amplified gene silencing in cancer cells. Nanoscale, 10(28), 13432–13442.PubMedCrossRefPubMedCentralGoogle Scholar
  121. 121.
    Rujitanaroj, P. O., Jao, B., Yang, J., Wang, F., Anderson, J. M., Wang, J., & Chew, S. Y. (2013). Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) expression by nanofiber-mediated siRNA gene silencing. Acta Biomaterialia, 9(1), 4513–4524.PubMedCrossRefPubMedCentralGoogle Scholar
  122. 122.
    Rujitanaroj, P. O., Wang, Y. C., Wang, J., & Chew, S. Y. (2011). Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications. Biomaterials, 32(25), 5915–5923.PubMedCrossRefPubMedCentralGoogle Scholar
  123. 123.
    Sakai, S., Yamada, Y., Yamaguchi, T., Ciach, T., & Kawakami, K. (2009). Surface immobilization of poly(ethyleneimine) and plasmid DNA on electrospun poly(L-lactic acid) fibrous mats using a layer-by-layer approach for gene delivery. Journal of Biomedical Materials Research. Part A, 88(2), 281–287.PubMedCrossRefPubMedCentralGoogle Scholar
  124. 124.
    Saraf, A., Baggett, L., Raphael, R., Kasper, F., & Mikos, A. (2009). Regulated non-viral gene delivery from coaxial electrospun fiber mesh scaffolds. Journal of Controlled Release: Official Journal of the Controlled Release Society, 143, 95–103.CrossRefGoogle Scholar
  125. 125.
    Wang, W., Zhang, K., & Chen, D. (2018). From tunable DNA/polymer self-assembly to tailorable and morphologically pure core-shell nanofibers. Langmuir, 34(50), 15350–15359.PubMedCrossRefPubMedCentralGoogle Scholar
  126. 126.
    Yang, Y., Li, X., Cheng, L., He, S., Zou, J., Chen, F., & Zhang, Z. (2011). Core-sheath structured fibers with pDNA polyplex loadings for the optimal release profile and transfection efficiency as potential tissue engineering scaffolds. Acta Biomaterialia, 7(6), 2533–2543.PubMedCrossRefPubMedCentralGoogle Scholar
  127. 127.
    Zou, B., Liu, Y., Luo, X., Chen, F., Guo, X., & Li, X. (2012). Electrospun fibrous scaffolds with continuous gradations in mineral contents and biological cues for manipulating cellular behaviors. Acta Biomaterialia, 8(4), 1576–1585.PubMedCrossRefPubMedCentralGoogle Scholar
  128. 128.
    Wilhelm, S., Tavares, A. J., Dai, Q., Ohta, S., Audet, J., Dvorak, H. F., & Chan, C. (2016). Analysis of nanoparticle delivery to tumours. Nature Reviews Materials, 1(5), 16014.CrossRefGoogle Scholar
  129. 129.
    Agarwal, S., Wendorff, J. H., & Greiner, A. (2009). Progress in the field of electrospinning for tissue engineering applications. Advanced Materials, 21(32–33), 3343–3351.PubMedCrossRefPubMedCentralGoogle Scholar
  130. 130.
    Williams, G., Chatterton, N., Nazir, T., Yu, D., Zhu, L.-M., & Branford-White, C. (2012). Electrospun nanofibers in drug delivery: Recent developments and perspectives. Therapeutic Delivery, 3, 515–533.PubMedCrossRefPubMedCentralGoogle Scholar
  131. 131.
    Lee, S., Cho, S., Kim, M., Jin, G., Jeong, U., & Jang, J.-H. (2014). Highly moldable electrospun clay-like fluffy nanofibers for three-dimensional scaffolds. ACS Applied Materials & Interfaces, 6, 1082–1091.CrossRefGoogle Scholar
  132. 132.
    Shimanovich, U., Tkacz, I., Eliaz, D., Cavaco-Paulo, A., Michaeli, S., & Gedanken, A. (2011). Encapsulation of RNA molecules in BSA microspheres and internalization into Trypanosoma Brucei parasites and human U2OS cancer cells. Advanced Functional Materials, 21, 3659–3666.CrossRefGoogle Scholar
  133. 133.
    Trabulo, S., Resina, S., Lebleu, B., Pedroso de Lima, M., Trabulo, S., Resina, S., Simões, S., Lebleu, B., & Pedroso de Lima, M. C. (2010). A non-covalent strategy combining cationic lipids and CPPs to enhance the delivery of splice correcting oligonucleotides. Journal of Controlled Release: Official Journal of the Controlled Release Society, 145, 149–158.CrossRefGoogle Scholar
  134. 134.
    Achille, C., Sundaresh, S., Chu, B., & Hadjiargyrou, M. (2012). Cdk2 silencing via a DNA/PCL electrospun scaffold suppresses proliferation and increases death of breast cancer cells. PLoS One, 7, e52356.PubMedPubMedCentralCrossRefGoogle Scholar
  135. 135.
    Xie, J. (2015). Expanding two-dimensional electrospun nanofiber membranes in the third dimension by a modified gas-foaming technique. ACS Bimaterials Science & Engineering, 1, 991.CrossRefGoogle Scholar
  136. 136.
    Bago, R., Pegna, G. J., Okolie, O., Mohiti-Asli, M., Loboa, E., & Hingtgen, S. (2016). Electrospun nanofibrous scaffolds increase the efficacy of stem cell-mediated therapy of surgically resected glioblastoma. Biomaterials, 90, 116.PubMedPubMedCentralCrossRefGoogle Scholar
  137. 137.
    Wang, Z., Ma, R., Yan, L., Chen, X., & Zhu, G. (2015). Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance. Chemical Communications (Camb), 51(58), 11587–11590.CrossRefGoogle Scholar
  138. 138.
    Liu, Y., Zhang, X., Zhou, M., Nan, X., Chen, X., & Zhang, X. (2017). Mitochondrial-targeting Lonidamine-doxorubicin nanoparticles for synergistic chemotherapy to conquer drug resistance. ACS Applied Materials & Interfaces, 9(50), 43498–43507.CrossRefGoogle Scholar
  139. 139.
    Fu, Y., Li, X., Ren, Z., Mao, C., & Han, G. (2018). Multifunctional electrospun nanofibers for enhancing localized cancer treatment. Small, e1801183.Google Scholar
  140. 140.
    Blanco, E., Shen, H., & Ferrari, M. (2015). Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nature Biotechnology, 33(9), 941–951.PubMedPubMedCentralCrossRefGoogle Scholar
  141. 141.
    He, Y., Li, X., Ma, J., Ni, G., Yang, G., & Zhou, S. (2019). Programmable codelivery of doxorubicin and Apatinib using an implantable hierarchical-structured Fiber device for overcoming cancer multidrug resistance. Small, 15(8), 1804397.CrossRefGoogle Scholar
  142. 142.
    Xiao, Y., Shen, M., & Shi, X. (2018). Design of functional electrospun nanofibers for cancer cell capture applications. Journal of Materials Chemistry B, 6(10), 1420–1432.PubMedCrossRefPubMedCentralGoogle Scholar
  143. 143.
    Zhao, Y., Fan, Z., Shen, M., & Shi, X. (2015). Hyaluronic acid-functionalized electrospun polyvinyl alcohol/Polyethylenimine nanofibers for Cancer cell capture applications. Advanced Materials Interfaces, 2(15), 1500256.CrossRefGoogle Scholar
  144. 144.
    Zhao, Y., Zhu, X., Liu, H., Luo, Y., Wang, S., Shen, M., Zhu, M., & Shi, X. (2014). Dendrimer-functionalized electrospun cellulose acetate nanofibers for targeted cancer cell capture applications. Journal of Materials Chemistry B, 2(42), 7384–7393.PubMedCrossRefPubMedCentralGoogle Scholar
  145. 145.
    Wang, S., Zhu, J., Shen, M., Zhu, M., & Shi, X. (2014). Poly(amidoamine) Dendrimer-enabled simultaneous stabilization and functionalization of electrospun poly(γ-glutamic acid) nanofibers. ACS Applied Materials & Interfaces, 6, 2153.CrossRefGoogle Scholar
  146. 146.
    Zhang, N., Deng, Y., Tai, Q., Cheng, B., Zhao, L., Shen, Q., He, R., Hong, L., Liu, W., Guo, S., et al. (2012). Electrospun TiO2 nanofiber-based cell capture assay for detecting circulating tumor cells from colorectal and gastric cancer patients. Advanced Materials, 24(20), 2756–2760.PubMedCrossRefPubMedCentralGoogle Scholar
  147. 147.
    Zha, Z., Cohn, C., Dai, Z., Qiu, W., Zhang, J., & Wu, X. (2011). Nanofibrous lipid membranes capable of functionally immobilizing antibodies and capturing specific cells. Advanced Materials, 23(30), 3435–3440.PubMedCrossRefPubMedCentralGoogle Scholar
  148. 148.
    Zha, Z., Jiang, L., Dai, Z., & Wu, X. (2012). A biomimetic mechanism for antibody immobilization on lipid nanofibers for cell capture. Applied Physics Letters, 101(19), 193701.PubMedPubMedCentralCrossRefGoogle Scholar
  149. 149.
    Sun, N., Liu, M., Jine, W., Zhili, W., Li, X., Jiang, B., & Pei, R. (2016). Chitosan nanofibers for specific capture and nondestructive release of CTCs assisted by pCBMA brushes. Small, 12, 5090–5097.PubMedCrossRefPubMedCentralGoogle Scholar
  150. 150.
    Yoon, J., Yoon, H. S., Shin, Y., Kim, S., Ju, Y., Kim, J., & Chung, S. (2017). Ethanol-dispersed and antibody-conjugated polymer nanofibers for the selective capture and 3-dimensional culture of EpCAM-positive cells. Nanomedicine, 13(5), 1617–1625.PubMedCrossRefPubMedCentralGoogle Scholar
  151. 151.
    Jackson, J. M., Witek, M. A., Kamande, J. W., & Soper, S. A. (2017). Materials and microfluidics: Enabling the efficient isolation and analysis of circulating tumour cells. Chemical Society Reviews, 46(14), 4245–4280.PubMedPubMedCentralCrossRefGoogle Scholar
  152. 152.
    Myung, J. H., & Hong, S. (2015). Microfluidic devices to enrich and isolate circulating tumor cells. Lab on a Chip, 15(24), 4500–4511.PubMedPubMedCentralCrossRefGoogle Scholar
  153. 153.
    Liu, Z., Zhang, W., Huang, F., Feng, H., Shu, W., Xu, X., & Chen, Y. (2013). High throughput capture of circulating tumor cells using an integrated microfluidic system. Biosensors & Bioelectronics, 47, 113–119.CrossRefGoogle Scholar
  154. 154.
    Liu, H.-Q., Yu, X.-L., Cai, B., You, S.-J., He, Z., Huang, Q.-Q., Rao, L., Li, S.-S., Liu, C., Sun, W.-W., et al. (2015). Capture and release of cancer cells using electrospun etchable MnO2 nanofibers integrated in microchannels. Applied Physics Letters, 106, 093703.CrossRefGoogle Scholar
  155. 155.
    Hou, S., Zhao, L., Shen, Q., Yu, J., Ng, C., Kong, X., Wu, D., Song, M., Shi, X., Xu, X., et al. (2013). Inside back cover: Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma. Cells Angewandte Chemie International Edition, 52(12), 3533–3533.CrossRefGoogle Scholar
  156. 156.
    Wu, L., & Qu, X. (2015). Cancer biomarker detection: Recent achievements and challenges. Chemical Society Reviews, 44, 2963–2997.PubMedCrossRefPubMedCentralGoogle Scholar
  157. 157.
    Rakovich, T., Mahfoud, O., Mohamed, B., Prina-Mello, A., Crosbie Staunton, K., Van Den Broeck, T., De Kimpe, L., Sukhanova, A., Baty, D., Rakovich, A., et al. (2014). Highly sensitive single domain antibody-quantum dot conjugates for detection of HER2 biomarker in lung and breast cancer cells. ACS Nano, 8, 5682.PubMedCrossRefPubMedCentralGoogle Scholar
  158. 158.
    Xu, J.-J., Zhao, W.-W., Song, S., Fan, C., & Chen, H.-Y. (2014). ChemInform abstract: Functional nanoprobes for ultrasensitive detection of biomolecules: An update. ChemInform, 45(18), 1601–1611.Google Scholar
  159. 159.
    Yu Ding, Y., Wang, Y., Su, L., Bellagamba, M., Zhang, H., & Lei, Y. (2010). Electrospun Co(3)O(4) nanofibers for sensitive and selective glucose detection. Biosensors & Bioelectronics, 26, 542–548.CrossRefGoogle Scholar
  160. 160.
    Hu, J., & Easley, C. (2011). A simple and rapid approach for measurement of dissociation constants of DNA aptamers against proteins and small molecules via automated microchip electrophoresis. The Analyst, 136, 3461–3468.PubMedCrossRefPubMedCentralGoogle Scholar
  161. 161.
    Hu, J., Sollie, R., & Easley, C. (2010). Improvement of sensitivity and dynamic range in proximity ligation assays by asymmetric connector hybridization. Analytical Chemistry, 82, 6976–6982.PubMedCrossRefPubMedCentralGoogle Scholar
  162. 162.
    Wang, X., Wang, X., Wang, X., Chen, F., Zhu, K., & Tang, M. (2013). Novel electrochemical biosensor based on functional composite nanofibers for sensitive detection of p53 tumor suppressor gene. Analytica Chimica Acta, 765, 63–69.PubMedCrossRefPubMedCentralGoogle Scholar
  163. 163.
    Davis, B., Niamnont, N., Hare, C., Sukwattanasinitt, M., & Cheng, Q. (2010). Nanofibers doped with dendritic fluorophores for protein detection. ACS Applied Materials & Interfaces, 2, 1798–1803.CrossRefGoogle Scholar
  164. 164.
    Hu, J., Wang, T., Shannon, C., & Easley, C. (2012). Quantitation of Femtomolar protein levels via direct readout with the electrochemical proximity assay. Journal of the American Chemical Society, 134, 7066–7072.PubMedPubMedCentralCrossRefGoogle Scholar
  165. 165.
    Hu, J., Yu, Y., Brooks, J., Godwin, L., Somasundaram, S., Torabinejad, F., Shannon, C., & Easley, C. (2014). A reusable electrochemical proximity assay for highly selective, real-time protein quantitation in biological matrices. Journal of the American Chemical Society, 136, 8467–8474.PubMedPubMedCentralCrossRefGoogle Scholar
  166. 166.
    Wang, X., Shu, G., Gao, C., Yang, Y., & Tang, M. (2014). Electrochemical biosensor based on functional composite nanofibers for detection of K-ras gene via multiple signal amplification strategy. Analytical Biochemistry, 466, 51–58.PubMedCrossRefPubMedCentralGoogle Scholar
  167. 167.
    Bohunicky, B., & Mousa, S. (2010). Biosensors: The new wave in cancer diagnosis. Nanotechnology, Science and Applications, 4, 1–10.PubMedPubMedCentralGoogle Scholar
  168. 168.
    Dorothee, G., MacKenzie, R., Janos, V. r. s., & Reimhult, E. (2008). Electrochemical biosensors - sensor principles and architectures. Sensors, 8(3), 1400–1458.CrossRefGoogle Scholar
  169. 169.
    Wei, Y., Li, X., Sun, X., Ma, H., Zhang, Y., & Wei, Q. (2017). Dual-responsive electrochemical immunosensor for prostate specific antigen detection based on au-CoS/graphene and CeO 2 /ionic liquids doped with carboxymethyl chitosan complex. Biosensors and Bioelectronics, 94, 141–147.PubMedCrossRefPubMedCentralGoogle Scholar
  170. 170.
    Mehrvar, M., & Abdi, M. (2004). Recent developments, characteristics, and potential applications of electrochemical biosensors. Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry, 20, 1113–1126.CrossRefGoogle Scholar
  171. 171.
    Marcus, R., & Sutin, N. (1985). Electron transfers in chemistry and biology. Biochimica Et Biophysica Acta (bba) - Reviews on Bioenergetics, 811, 265–322.CrossRefGoogle Scholar
  172. 172.
    Putzbach, W., & Ronkainen, N. (2013). ChemInform abstract: Immobilization techniques in the fabrication of nanomaterial-based electrochemical biosensors: A review. Sensors (Basel, Switzerland), 13, 4811–4840.CrossRefGoogle Scholar
  173. 173.
    Tilmaciu, C., & Morris, M. (2015). Carbon nanotube biosensors. Frontiers in Chemistry, 3, 1–21.CrossRefGoogle Scholar
  174. 174.
    Tyagi, S., & Kramer, F. R. (1996). Molecular beacons: Probes that fluoresce upon hybridization. Nature Biotechnology, 14(3), 303–308.PubMedCrossRefPubMedCentralGoogle Scholar
  175. 175.
    Medina, V., & Rivera, E. (2010). Histamine receptors and cancer pharmacology. British Journal of Pharmacology, 161, 755–767.PubMedPubMedCentralCrossRefGoogle Scholar
  176. 176.
    Seong, D., Choi, M.-S., & Kim, Y.-J. (2012). Fluorescent chemosensor for the detection of histamine based on dendritic porphyrin-incorporated nanofibers. European Polymer Journal, 48, 1988–1996.CrossRefGoogle Scholar
  177. 177.
    Kosaki, Y., Izawa, H., Ishihara, S., Kawakami, K., Sumita, M., Tateyama, Y., Ji, Q., Krishnan, V., Hishita, S., Yamauchi, Y., et al. (2013). Nanoporous carbon sensor with cage-in-fiber structure: Highly selective aniline adsorbent toward cancer risk management. ACS Applied Materials & Interfaces, 5, 2930–2934.CrossRefGoogle Scholar
  178. 178.
    Peng, G., Tisch, U., Adams, O., Hakim, M., Shehada, N., Broza, Y., Billan, S., Abdah-Bortnyak, R., Kuten, A., & Haick, H. (2009). Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nature Nanotechnology, 4, 669–673.PubMedCrossRefPubMedCentralGoogle Scholar
  179. 179.
    Yu, H., Xu, L., Cao, M., Chen, X., Wang, P., Jiao, J., & Wang, Y. (2003). Detection volatile organic compounds in breath as markers of lung cancer using a novel electronic nose, 2003.Google Scholar
  180. 180.
    Choi, S.-H., Ankonina, G., Youn, D.-Y., Oh, S.-G., Hong, J.-M., Rothschild, A., & Kim, I.-D. (2009). Hollow ZnO nanofibers fabricated using electrospun polymer templates and their electronic transport properties. ACS Nano, 3, 2623–2631.PubMedCrossRefPubMedCentralGoogle Scholar
  181. 181.
    Zhang, Y., He, X., Li, J., Miao, Z., & Huang, F. (2008). Fabrication and ethanol-sensing properties of micro gas sensor based on electrospun SnO2 nanofibers. Sensors and Actuators B: Chemical, 132, 67–73.CrossRefGoogle Scholar
  182. 182.
    Lee, C., Kim, I.-D., & Lee, J.-H. (2013). Selective and sensitive detection of trimethylamine using ZnO–In2O3 composite nanofibers. Sensors and Actuators B: Chemical, 181, 463–470.CrossRefGoogle Scholar
  183. 183.
    Choi, S.-J., Kim, S.-J., Koo, W.-T., Cho, H.-J., & Kim, I.-D. (2014). Catalyst-loaded porous WO3 nanofibers using catalyst-decorated polystyrene colloid templates for detection of biomarker molecules. Chemical Communications, 51, 2609.CrossRefGoogle Scholar
  184. 184.
    Adiguzel, Y., & Kulah, H. (2015). Breath sensors for lung cancer diagnosis. Biosensors and Bioelectronics, 65, 121–138.Google Scholar
  185. 185.
    Kim, S.-J., Choi, S.-J., Yang, D.-J., Bae, J., Park, J., & Kim, I.-D. (2014). Highly sensitive and selective hydrogen sulfide and toluene sensors using Pd functionalized WO3 nanofibers for potential diagnosis of halitosis and lung cancer. Sensors and Actuators B: Chemical, 193, 574–581.Google Scholar
  186. 186.
    Kimmel, D., Leblanc, G., Meschievitz, M., & Cliffel, D. (2011). Electrochemical sensors and biosensors. Analytical Chemistry, 84, 685–707.PubMedPubMedCentralCrossRefGoogle Scholar
  187. 187.
    Scanlon, M., Salaj-Kosla, U., Belochapkine, S., MacAodha, D., Leech, D., Ding, Y., & Magner, E. (2012). Characterization of nanoporous gold electrodes for bioelectrochemical applications. Langmuir: The ACS Journal of Surfaces and Colloids, 28, 2251–2261.CrossRefGoogle Scholar
  188. 188.
    Ali, M. A., Mondal, K., Singh, C., Malhotra, B., & Sharma Iitk, A. (2015). Anti-epidermal growth factor receptor conjugated mesoporous zinc oxide nanofibers for breast cancer diagnostics. Nanoscale, 7, 7234–7245.PubMedCrossRefPubMedCentralGoogle Scholar
  189. 189.
    Frenot, A., & Chronakis, I. (2003). Polymer nanofibers assembled by electrospinning. Current Opinion in Colloid & Interface Science, 8, 64–75.CrossRefGoogle Scholar
  190. 190.
    Zhang, C.-L., & Yu, S.-H. (2014). Nanoparticles meet electrospinning: Recent advances and future prospects. Chemical Society Reviews, 43, 4423–4448.PubMedCrossRefPubMedCentralGoogle Scholar
  191. 191.
    Jordan, A., Scholz, R., Maier-Hauff, K., van Landeghem, F. K., Waldoefner, N., Teichgraeber, U., Pinkernelle, J., Bruhn, H., Neumann, F., Thiesen, B., et al. (2006). The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma. Journal of Neuro-Oncology, 78(1), 7–14.PubMedCrossRefPubMedCentralGoogle Scholar
  192. 192.
    Yanase, M., Shinkai, M., Honda, H., Wakabayashi, T., Yoshida, J., & Kobayashi, T. (1998). Intracellular hyperthermia for cancer using magnetite cationic liposomes: An in vivo study. Japanese Journal of Cancer Research, 89(4), 463–470.PubMedCrossRefPubMedCentralGoogle Scholar
  193. 193.
    Hervault, A., & Thanh, N. T. (2014). Magnetic nanoparticle-based therapeutic agents for thermo-chemotherapy treatment of cancer. Nanoscale, 6(20), 11553–11573.PubMedCrossRefPubMedCentralGoogle Scholar
  194. 194.
    Kobayashi, T. (2011). Cancer hyperthermia using magnetic nanoparticles. Biotechnology Journal, 6(11), 1342–1347.PubMedCrossRefPubMedCentralGoogle Scholar
  195. 195.
    Santhosh, P. B., & Ulrih, N. P. (2013). Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics. Cancer Letters, 336(1), 8–17.PubMedCrossRefPubMedCentralGoogle Scholar
  196. 196.
    Mfiller, R. H., Maaben, S., Weyhers, L. H., Specht, F., & Lucks, J. S. (1996). Cytotoxicity of magnetite-loaded polylactide, polylactide-glycolide particles and solid lipid nanoparticles. International Journal of Pharmaceutics, 138, 85–94.CrossRefGoogle Scholar
  197. 197.
    Weissleder, R., Bogdanov, A., Neuweltb, E. A., & Papisov, M. (1995). Long-circulating iron oxides for MR imaging. Advanced Drug Delivery Reviews, 16, 321–334.CrossRefGoogle Scholar
  198. 198.
    Kaminski, M. D., & Rosengart, A. J. (2005). Detoxification of blood using injectable magnetic nanospheres: A conceptual technology description. Journal of Magnetism and Magnetic Materials, 293(1), 398–403.CrossRefGoogle Scholar
  199. 199.
    Feng, Z.-Q., Shi, C., Zhao, B., & Wang, T. (2017). Magnetic electrospun short nanofibers wrapped graphene oxide as a promising biomaterials for guiding cellular behavior. Materials Science and Engineering: C, 81, 314–320.CrossRefGoogle Scholar
  200. 200.
    Huang, C., Soenen, S. J., Rejman, J., Trekker, J., Chengxun, L., Lagae, L., Ceelen, W., Wilhelm, C., Demeester, J., & De Smedt, S. C. (2012). Magnetic electrospun fibers for cancer therapy. Advanced Functional Materials, 22(12), 2479–2486.CrossRefGoogle Scholar
  201. 201.
    Sasikala, A. R. K., Unnithan, A. R., Yun, Y.-H., Park, C. H., & Kim, C. S. (2016). An implantable smart magnetic nanofiber device for endoscopic hyperthermia treatment and tumor-triggered controlled drug release. Acta Biomaterialia, 31, 122–133.PubMedCrossRefPubMedCentralGoogle Scholar
  202. 202.
    Song, C., Wang, X. X., Zhang, J., Nie, G. D., Luo, W. L., Fu, J., Ramakrishna, S., & Long, Y. Z. (2018). Electric field-assisted in situ precise deposition of electrospun gamma-Fe2O3/polyurethane nanofibers for magnetic hyperthermia. Nanoscale Research Letters, 13(1), 273.PubMedPubMedCentralCrossRefGoogle Scholar
  203. 203.
    Radmansouri, M., Bahmani, E., Sarikhani, E., Rahmani, K., Sharifianjazi, F., & Irani, M. (2018). Doxorubicin hydrochloride - loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers for hyperthermic tumor cell treatment and controlled drug release. International Journal of Biological Macromolecules, 116, 378–384.PubMedCrossRefPubMedCentralGoogle Scholar
  204. 204.
    Chen, Z., Chen, Z., Zhang, A., Hu, J., Wang, X., & Yang, Z. (2016). Electrospun nanofibers for cancer diagnosis and therapy. Biomaterials Science, 4(6), 922–932.PubMedCrossRefPubMedCentralGoogle Scholar
  205. 205.
    Fan, Y., Chen, C., Huang, Y., Zhang, F., & Lin, G. (2017). Study of the pH-sensitive mechanism of tumor-targeting liposomes. Colloids and Surfaces. B, Biointerfaces, 151, 19–25.PubMedCrossRefPubMedCentralGoogle Scholar
  206. 206.
    Demirci, S., Celebioglu, A., Aytac, Z., & Uyar, T. (2014). pH-responsive nanofibers with controlled drug release properties. Polymer Chemistry, 5(6), 2050–2056.CrossRefGoogle Scholar
  207. 207.
    Thakkar, S., & Misra, M. (2017). Electrospun polymeric nanofibers: New horizons in drug delivery. European Journal of Pharmaceutical Sciences, 107, 148–167.PubMedCrossRefPubMedCentralGoogle Scholar
  208. 208.
    Illangakoon, U. E., Yu, D. G., Ahmad, B. S., Chatterton, N. P., & Williams, G. R. (2015). 5-fluorouracil loaded Eudragit fibers prepared by electrospinning. International Journal of Pharmaceutics, 495(2), 895–902.PubMedCrossRefPubMedCentralGoogle Scholar
  209. 209.
    Han, D., & Steckl, A. J. (2017). Selective pH-responsive core-sheath nanofiber membranes for Chem/bio/med applications: Targeted delivery of functional molecules. ACS Applied Materials & Interfaces, 9(49), 42653–42660.CrossRefGoogle Scholar
  210. 210.
    Tran, T., Hernandez, M., Patel, D., Burns, E., Peterman, V., & Wu, J. (2015). Controllable and switchable drug delivery of ibuprofen from temperature responsive composite nanofibers. Nano Convergence, 2(1), 15.CrossRefGoogle Scholar
  211. 211.
    Zhang, R. Y., Zaslavski, E., Vasilyev, G., Boas, M., & Zussman, E. (2018). Tunable pH-responsive chitosan-poly(acrylic acid) electrospun fibers. Biomacromolecules, 19(2), 588–595.PubMedCrossRefPubMedCentralGoogle Scholar
  212. 212.
    Sang, Q., Williams, G. R., Wu, H., Liu, K., Li, H., & Zhu, L. M. (2017). Electrospun gelatin/sodium bicarbonate and poly(lactide-co-epsilon-caprolactone)/sodium bicarbonate nanofibers as drug delivery systems. Materials Science & Engineering. C, Materials for Biological Applications, 81, 359–365.CrossRefGoogle Scholar
  213. 213.
    Jassal, M., Boominathan, V., Ferreira, T., Sengupta, S., & Bhowmick, S. (2016). pH-responsive drug release from functionalized electrospun poly(caprolactone) scaffolds under simulated in-vivo environment. Journal of Biomaterials Science, Polymer Edition, 27, 1–34.CrossRefGoogle Scholar
  214. 214.
    Toncheva, A., Paneva, D., Maximova, V., Manolova, N., & Rashkov, I. (2012). Antibacterial fluoroquinolone antibiotic-containing fibrous materials from poly(L-lactide-co-D,L-lactide) prepared by electrospinning. European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences, 47, 642–651.CrossRefGoogle Scholar
  215. 215.
    Ercole, F., Davis, T., & Evans, R. (2010). Photo-responsive systems and biomaterials: Photochromic polymers, light-triggered self-assembly, surface modification, fluorescence modulation and beyond. Polymer Chemistry, 1, 37.CrossRefGoogle Scholar
  216. 216.
    Gorostiza, P., & Isacoff, E. (2008). Optical switches for remote and noninvasive control of cell signaling. Science (New York, N.Y.), 322, 395–399.CrossRefGoogle Scholar
  217. 217.
    Yu, Y., Nakano, M., & Ikeda, T. (2003). Directed bending of a polymer film by light. Nature, 425(6954), 145–145.PubMedCrossRefPubMedCentralGoogle Scholar
  218. 218.
    Klajn, R., Wesson, P., Bishop, K., & Grzybowski, B. (2009). Writing self-erasing images using metastable nanoparticle “inks”. Angewandte Chemie (International Ed. in English), 48, 7035–7039.CrossRefGoogle Scholar
  219. 219.
    Davis, M., Brewster, M., Davis, M. E., & Brewster, M. E. (2005). Cyclodextrin-based pharmaceutics: Past, present and future. Nature Reviews. Drug Discovery, 3, 1023–1035.CrossRefGoogle Scholar
  220. 220.
    Wang, Y., Ma, N., Wang, Z., & Zhang, X. (2007). Photocontrolled reversible supramolecular assemblies of an Azobenzene-containing surfactant with α-Cyclodextrin. Angewandte Chemie (International Ed. in English), 46, 2823–2826.CrossRefGoogle Scholar
  221. 221.
    Fu, G., Xu, L., Yao, F., Li, G., & Kang, E. (2009). Smart nanofibers with a Photoresponsive surface for controlled release. ACS Applied Materials & Interfaces, 1, 2424–2427.CrossRefGoogle Scholar
  222. 222.
    Weissleder, R. (2001). A clearer vision for in vivo imaging. Nature Biotechnology, 19, 316–317.PubMedCrossRefPubMedCentralGoogle Scholar
  223. 223.
    Chen, J., Guo, Z., Wang, H. B., Gong, M., Kong, X. K., Xia, P., & Chen, Q. W. (2013). Multifunctional Fe3O4@C@ag hybrid nanoparticles as dual modal imaging probes and near-infrared light-responsive drug delivery platform. Biomaterials, 34(2), 571–581.PubMedCrossRefPubMedCentralGoogle Scholar
  224. 224.
    Kurapati, R., & Raichur, A. (2013). Near-infrared light-responsive graphene oxide composite multilayer capsules: A novel route for remote controlled drug delivery. Chemical Communications, 49, 734.PubMedCrossRefPubMedCentralGoogle Scholar
  225. 225.
    Yashchenok, A., Bratashov, D., Gorin, D., Lomova, M., Pavlov, A., Sapelkin, A., Shim, B., Khomutov, G., Kotov, N., Sukhorukov, G., et al. (2010). Carbon nanotubes on polymeric microcapsules: Free-standing structures and point-wise laser openings. Advanced Functional Materials, 20, 3136–3142.CrossRefGoogle Scholar
  226. 226.
    Zhang, Z., Wang, L., Wang, J., Jiang, X.-M., Li, X., Hu, Z., Yinglu, J., Wu, X., Chen, C., Zhang, Z., Wang, L., Wang, J., Jiang, X., Li, X., Hu, Z., Ji, Y., Wu, X., & Chen, C. (2012). Mesoporous silica-coated gold nanorods as a light-mediated multifunctional theranostic platform for cancer treatment. Advanced Materials (Deerfield Beach, Fla.), 24, 1418–1423.CrossRefGoogle Scholar
  227. 227.
    Cobley, C., Chen, J., Cho, E., Wang, L., & Xia, Y. (2011). ChemInform abstract: Gold nanostructures: A class of multifunctional materials for biomedical applications. Chemical Society Reviews, 40, 44–56.PubMedCrossRefPubMedCentralGoogle Scholar
  228. 228.
    Kang, H., Trondoli, A., Zhu, G., Chen, Y., Chang, Y.-J., Liu, H., Huang, Y.-F., Zhang, X., & Tan, W. (2011). Near-infrared light-responsive Core-Shell Nanogels for targeted drug delivery. ACS Nano, 5, 5094–5099.PubMedPubMedCentralCrossRefGoogle Scholar
  229. 229.
    Hribar, K., Lee, M., Lee, D. H., & Burdick, J. (2011). Enhanced release of small molecules from near-infrared light responsive polymer-Nanorod composites. ACS Nano, 5, 2948–2956.PubMedCrossRefPubMedCentralGoogle Scholar
  230. 230.
    Wei, Q., Ji, J., & Shen, J. (2008). Synthesis of near-infrared responsive gold Nanorod/PNIPAAm Core/Shell Nanohybrids via surface initiated ATRP for smart drug delivery. Macromolecular Rapid Communications, 29, 645–650.CrossRefGoogle Scholar
  231. 231.
    Sivakumaran, D., Bakaic, E., Campbell, S., Xu, F., Mueller, E., & Hoare, T. (2018). Fabricating degradable thermoresponsive hydrogels on multiple length scales via reactive extrusion, microfluidics, self-assembly, and electrospinning. Journal of Visualized Experiments, 2018, 54502.Google Scholar
  232. 232.
    Liu, L., Bai, S., Yang, H., Li, S., Quan, J., Zhu, L., & Nie, H. (2016). Controlled release from thermo-sensitive PNVCL-co-MAA electrospun nanofibers: The effects of hydrophilicity/hydrophobicity of a drug. Materials Science and Engineering: C, 67, 581–589.CrossRefGoogle Scholar
  233. 233.
    Slemming-Adamsen, P., Song, J., Dong, M., Besenbacher, F., & Chen, M. (2015). In situ cross-linked pNIPAM/gelatin nanofibers for thermo-responsive drug release. Macromolecular Materials and Engineering, 300, 1226–1231.Google Scholar
  234. 234.
    Zhang, H., Niu, Q., Wang, N., Nie, J., & Ma, G. (2015). Thermo-sensitive drug controlled release PLA core/ pNIPAM shell fibers fabricated using a combination of electrospinning and UV photo-polymerization. European Polymer Journal, 71, 440–451.Google Scholar
  235. 235.
    Cicotte, K., Reed, J., Nguyen, P., Lora, J., Dirk, E., & Canavan, H. (2017). Optimization of electrospun poly( N- isopropyl acrylamide) mats for the rapid reversible adhesion of mammalian cells. Biointerphases, 12, 02C417.PubMedPubMedCentralCrossRefGoogle Scholar
  236. 236.
    Liu, L., Bakhshi, H., Shaohua, J., Schmalz, H., & Agarwal, S. (2018). Composite polymeric membranes with directionally embedded fibers for controlled dual actuation. Macromolecular Rapid Communications, 39, 1800082.CrossRefGoogle Scholar
  237. 237.
    Li, H., Sang, Q., Wu, J., Williams, G., Wang, H., Niu, S., Wu, J., & Zhu, L.-M. (2018). Dual-responsive drug delivery systems prepared by blend electrospinning. International Journal of Pharmaceutics, 543, 1–7.PubMedCrossRefPubMedCentralGoogle Scholar
  238. 238.
    Li, H., Liu, K., Williams, G. R., Wu, J., Wu, J., Wang, H., Niu, S., & Zhu, L.-M. (2018). Dual temperature and pH responsive nanofiber formulations prepared by electrospinning. Colloids and Surfaces B: Biointerfaces, 171, 142–149.PubMedCrossRefPubMedCentralGoogle Scholar
  239. 239.
    Hu, J., Li, H.-Y., Williams, G., Yang, H.-H., Tao, L., & Zhu, L.-M. (2016). Electrospun poly(N-isopropylacrylamide)/ethyl cellulose nanofibers as thermoresponsive drug delivery systems. Journal of Pharmaceutical Sciences, 105(3), 1104–1112.PubMedCrossRefPubMedCentralGoogle Scholar
  240. 240.
    Han, D., Yu, X., Chai, Q., Ayres, N., & Steckl, A. (2017). Stimuli-responsive self-Immolative polymer nanofiber membranes formed by coaxial electrospinning. ACS Applied Materials & Interfaces, 9, 11858–11865.CrossRefGoogle Scholar
  241. 241.
    Wen, Y., & Collier, J. (2015). Supramolecular peptide vaccines: Tuning adaptive immunity. Current Opinion in Immunology, 35, 73–79.PubMedPubMedCentralCrossRefGoogle Scholar
  242. 242.
    Rudra, J., Tian, Y., Jung, P., & Collier, J. (2010). A self-assembling peptide acting as an immune adjuvant. Proceedings of the National Academy of Sciences of the United States of America, 107, 622–627.PubMedCrossRefPubMedCentralGoogle Scholar
  243. 243.
    Pompano, R., Chen, J., Verbus, E., Han, H., Fridman, A., McNeeley, T., Collier, J., & Chong, A. (2014). Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs. Advanced Healthcare Materials, 3, 1898–1908.PubMedPubMedCentralCrossRefGoogle Scholar
  244. 244.
    Hudalla, G., Sun, T., Gasiorowski, J., Han, H., Tian, Y., Chong, A., & Collier, J. (2014). Gradated assembly of multiple proteins into supramolecular nanomaterials. Nature Materials, 13, 829–836.PubMedPubMedCentralCrossRefGoogle Scholar
  245. 245.
    Wen, Y., Roudebush, S. L., Buckholtz, G. A., Goehring, T. R., Giannoukakis, N., Gawalt, E. S., & Meng, W. S. (2014). Coassembly of amphiphilic peptide EAK16-II with histidinylated analogues and implications for functionalization of beta-sheet fibrils in vivo. Biomaterials, 35(19), 5196–5205.PubMedCrossRefPubMedCentralGoogle Scholar
  246. 246.
    Zheng, Y., Wen, Y., George, A. M., Steinbach, A. M., Phillips, B. E., Giannoukakis, N., Gawalt, E. S., & Meng, W. S. (2011). A peptide-based material platform for displaying antibodies to engage T cells. Biomaterials, 32(1), 249–257.PubMedCrossRefPubMedCentralGoogle Scholar
  247. 247.
    Wen, Y., Liu, W., Bagia, C., Zhang, S., Bai, M., Janjic, J. M., Giannoukakis, N., Gawalt, E. S., & Meng, W. S. (2014). Antibody-functionalized peptidic membranes for neutralization of allogeneic skin antigen-presenting cells. Acta Biomaterialia, 10(11), 4759–4767.PubMedPubMedCentralCrossRefGoogle Scholar
  248. 248.
    Wen, Y., Kolonich, H. R., Kruszewski, K. M., Giannoukakis, N., Gawalt, E. S., & Meng, W. S. (2013). Retaining antibodies in tumors with a self-assembling injectable system. Molecular Pharmaceutics, 10(3), 1035–1044.PubMedCrossRefPubMedCentralGoogle Scholar
  249. 249.
    Tajima, A., Liu, W., Pradhan, I., Bertera, S., Bagia, C., Trucco, M., Meng, W. S., & Fan, Y. (2015). Bioengineering mini functional thymic units with EAK16-II/EAKIIH6 self-assembling hydrogel. Clinical Immunology, 160(1), 82–89.PubMedCrossRefPubMedCentralGoogle Scholar
  250. 250.
    Gottesman, M. M., Fojo, T., & Bates, S. E. (2002). Multidrug resistance in cancer: Role of ATP–dependent transporters. Nature Reviews Cancer, 2(1), 48–58.PubMedCrossRefPubMedCentralGoogle Scholar
  251. 251.
    Szakács, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C., & Gottesman, M. M. (2006). Targeting multidrug resistance in cancer. Nature Reviews Drug Discovery, 5(3), 219–234.PubMedCrossRefPubMedCentralGoogle Scholar
  252. 252.
    Zhang, Z., Wu, Y., Kuang, G., Liu, S., Zhou, D., Chen, X., Jing, X., & Huang, Y. (2017). Pt(iv) prodrug-backboned micelle and DCA loaded nanofibers for enhanced local cancer treatment. Journal of Materials Chemistry B, 5(11), 2115–2125.PubMedCrossRefPubMedCentralGoogle Scholar
  253. 253.
    Niiyama, E., Uto, K., Lee, C. M., Sakura, K., & Ebara, M. (2019). Hyperthermia nanofiber platform synergized by sustained release of paclitaxel to improve antitumor efficiency. Advanced Healthcare Materials, 8(13), e1900102.PubMedCrossRefPubMedCentralGoogle Scholar

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Authors and Affiliations

  1. 1.Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesRuijin Hospital, Shanghai Jiao Tong University School of MedicineShanghaiChina
  2. 2.Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, Department of OrthopaedicsThe Second Affiliated Hospital of Jiaxing UniversityJiaxingChina
  3. 3.The central laboratoryThe Second Affiliated Hospital of Jiaxing UniversityJiaxingChina

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