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Deep Learning Approach with Rotate-Shift Invariant Input to Predict Protein Homodimer Structure

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Bioinformatics Research and Applications (ISBRA 2020)

Part of the book series: Lecture Notes in Computer Science ((LNBI,volume 12304))

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Abstract

The ability to predict protein complexes is important for applications in drug design and generating models of high accuracy in the cell. Recently deep learning techniques showed a significant success in protein structure prediction, but a protein docking problem is unsolved yet. We developed a two-staged approach which consists of deep convolutional neural network to predict protein contact map for homodimers and optimization procedure based on gradient descent to build the homodimer structure from the contact map. Neural network uses the distance map calculated as all pairwise Euclidian distances between CB atoms of protein 3D structure as input, which is invariant to rotation and translation. The network has a large receptive filed to capture patterns in contacts between residues. The suggested approach could be generalized to heterodimers because it does not depend on symmetry features inherent in homodimers. The presented algorithm could be also used for scoring protein homodimers models in docking.

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Authors and Affiliations

  1. United Institute of Informatics Problems, National Academy of Sciences, 220012, Minsk, Belarus

    Anna Hadarovich, Alexander Kalinouski & Alexander V. Tuzikov

  2. Belarusian State University, 220030, Minsk, Belarus

    Anna Hadarovich & Alexander V. Tuzikov

Authors
  1. Anna Hadarovich
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  2. Alexander Kalinouski
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  3. Alexander V. Tuzikov
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Corresponding author

Correspondence to Anna Hadarovich .

Editor information

Editors and Affiliations

  1. Department of Computer Science, Georgia State University, Atlanta, GA, USA

    Zhipeng Cai

  2. University of Connecticut, Storrs Mansfield, CT, USA

    Ion Mandoiu

  3. Florida International University, Miami, FL, USA

    Giri Narasimhan

  4. Georgia State University, Atlanta, GA, USA

    Pavel Skums

  5. University of North Texas, Denton, TX, USA

    Xuan Guo

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Hadarovich, A., Kalinouski, A., Tuzikov, A.V. (2020). Deep Learning Approach with Rotate-Shift Invariant Input to Predict Protein Homodimer Structure. In: Cai, Z., Mandoiu, I., Narasimhan, G., Skums, P., Guo, X. (eds) Bioinformatics Research and Applications. ISBRA 2020. Lecture Notes in Computer Science(), vol 12304. Springer, Cham. https://doi.org/10.1007/978-3-030-57821-3_27

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  • DOI: https://doi.org/10.1007/978-3-030-57821-3_27

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-57820-6

  • Online ISBN: 978-3-030-57821-3

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