Abstract
Diagnosis of underactive bladder (UAB) is by clinical and urodynamic evaluation. The clinical evaluation is based firstly on the patient’s medical history, with the aim of assessing risk factors and sequelae associated with UAB, and secondly on an evaluation of urinary symptoms. However, the diagnosis of UAB from symptoms alone is difficult owing to the presence of symptoms that overlap with other bladder pathologies such as overactive bladder (OAB) or bladder outlet obstruction (BOO). We propose a new diagnostic algorithm for LUTS for distinguishing UAB, OAB and BOO patients. When diagnosis remains uncertain, urodynamics will evaluate contractility and a diagnosis of detrusor underactivity (DUA) will denote UAB. However, this is hindered by a lack of a gold-standard measurement for DUA in women. To date, the most effective diagnostic indicator of DUA in female patients is a PIP value <30.
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References
Chapple CR, Osman NI, Birder L, van Koeveringe GA, Oelke M, Nitti VW, et al. The underactive bladder: a new clinical concept? Eur Urol. 2015;68:351–3. https://doi.org/10.1016/j.eururo.2015.02.030.
Smith PP, Birder LA, Abrams P, Wein AJ, Chapple CR. Detrusor underactivity and the underactive bladder: symptoms, function, cause-what do we mean? ICI-RS think tank 2014. Neurourol Urodyn. 2016;35:312–7. https://doi.org/10.1002/nau.22807.
Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, et al. The standardisation of terminology in lower urinary tract function: report from the standardisation subcommittee of the International Continence Society. Urology. 2003;61:37–49.
Jeong SJ, Kim HJ, Lee YJ, Lee JK, Lee BK, Choo YM, et al. Prevalence and clinical features of detrusor underactivity among elderly with lower urinary tract symptoms: a comparison between men and women. Korean J Urol. 2012;53:342–8. https://doi.org/10.4111/kju.2012.53.5.342.
Aldamanhori R, Chapple CR. Underactive bladder, detrusor underactivity, definition, symptoms, epidemiology, etiopathogenesis, and risk factors. Curr Opin Urol. 2017;27:293–9. https://doi.org/10.1097/MOU.0000000000000381.
Chapple CR, Osman NI, Birder L, Dmochowski R, Drake MJ, van Koeveringe G, et al. Terminology report from the International Continence Society (ICS) Working Group on Underactive Bladder (UAB). Neurourol Urodyn. 2018;37:2928–31. https://doi.org/10.1002/nau.23701.
Li X, Liao LM, Chen GQ, Wang ZX, Lu TJ, Deng H. Clinical and urodynamic characteristics of underactive bladder: data analysis of 1726 cases from a single center. Medicine (Baltimore). 2018;97:e9610. https://doi.org/10.1097/MD.0000000000009610.
Araki I, Kitahara M, Oida T, Kuno S. Voiding dysfunction and Parkinsonʼs: urodynamic abnormalities and urinary symptoms. J Urol. 2000;164:1640–3.
Bloch F, Pichon B, Bonnet AM, Pichon J, Vidailhet M, Roze E, et al. Urodynamic analysis in multiple system atrophy: characterisation of detrusor-sphincter dyssynergia. J Neurol. 2010;257:1986–91. https://doi.org/10.1007/s00415-010-5645-x.
Yamamoto T, Sakakibara R, Uchiyama T, Yamaguchi C, Ohno S, Nomura F, et al. Time-dependent changes and gender differences in urinary dysfunction in patients with multiple system atrophy. Neurourol Urodyn. 2014;33:516–23. https://doi.org/10.1002/nau.22441.
Chapple CR, Osman NI. The underactive detrusor. In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, editors. Campbell-Walsh urology. 11th ed. Philadelphia, PA: Elsevier; 2016.
Litwiller SE, Frohman EM, Zimmern PE. Multiple sclerosis and the urologist. J Urol. 1999;161:743–57.
Taylor JA, Kuchel GA. Detrusor underactivity: clinical features and pathogenesis of an underdiagnosed geriatric condition. J Am Geriatr Soc. 2006;54:1920–32.
Gammie A, Kaper M, Dorrepaal C, Kos T, Abrams P. Signs and symptoms of detrusor underactivity: an analysis of clinical presentation and urodynamic tests from a large group of patients undergoing pressure flow studies. Eur Urol. 2016;69:361–9. https://doi.org/10.1016/j.eururo.2015.08.014.
Food and Drug Administration. Guidance for industry: patient-reported outcome measures: use in medical product development to support labeling claims; 2009.
Uren AD, Cotterill N, Harding C, Hillary C, Chapple C, Klaver M, et al. The development of the ICIQ-UAB: a patient reported outcome measure for underactive bladder. Neurourol Urodyn. 2019;38:996–1004. https://doi.org/10.1002/nau.23947.
Gani J, Hennessey D. The underactive bladder: diagnosis and surgical treatment options. Transl Androl Urol. 2017;6(Suppl 2):S186–95. https://doi.org/10.21037/tau.2017.04.07.
Hoag N, Gani J. Underactive bladder: clinical features, urodynamic parameters, and treatment. Int Neurourol J. 2015;19:185–9. https://doi.org/10.5213/inj.2015.19.3.185.
Groutz A, Gordon D, Lessing JB, Wolman I, Jaffa A, David MP. Prevalence and characteristics of voiding difficulties in women: are subjective symptoms substantiated by objective urodynamic data? Urology. 1999;54:268–72.
Abarbanel J, Marcus EL. Impaired detrusor contractility in community-dwelling elderly presenting with lower urinary tract symptoms. Urology. 2007;69:436–40.
Griffiths DJ. Editorial: bladder failure—a condition to reckon with. J Urol. 2003;169:1011–2.
Griffiths D. Detrusor contractility–order out of chaos. Scand J Urol Nephrol Suppl. 2004;215:93–100.
Lecamwasam HS, Yalla SV, Cravalho EG, Sullivan MP. The maximum watts factor as a measure of detrusor contractility independent of outlet resistance. Neurourol Urodyn. 1998;17:621–35.
Griffiths DJ. Assessment of detrusor contraction strength or contractility. Neurourol Urodyn. 1991;10:1–18.
Griffiths DJ, Constantinou CE, van Mastrigt R. Urinary bladder function and its control in healthy females. Am J Physiol. 1986;251:R225–30.
Griffiths DJ. The mechanics of the urethra and of micturition. Br J Urol. 1973;45:497–507.
Schafer W. Analysis of bladder-outlet function with the linearized passive urethral resistance relation, linPURR, and a disease-specific approach for grading obstruction: from complex to simple. World J Urol. 1995;3:47–58.
Abrams P. Bladder outlet obstruction index, bladder contractility index and bladder voiding efficiency: three simple indices to define bladder voiding function. BJU Int. 1999;84:14–5.
Cucchi A, Quaglini S, Rovereto B. Proposal for a urodynamic redefinition of detrusor underactivity. J Urol. 2009;181:225–9.
Cucchi A. Some observations on a condition of relatively lower detrusor contractility in stable versus unstable unobstructed bladders. Neurourol Urodyn. 1995;14:317–24.
Cucchi A, Quaglini S, Guarnaschelli C, Rovereto B. Urodynamic findings suggesting two-stage development of idiopathic detrusor underactivity in adult men. Urology. 2007;70:75–9.
Cucchi A, Quaglini S, Rovereto B. Different evolution of voiding function in underactive bladders with and without detrusor overactivity. J Urol. 2010;183:229–33. https://doi.org/10.1016/j.juro.2009.08.162.
Cucchi A, Quaglini S, Rovereto B. Development of idiopathic detrusor underactivity in women: from isolated decrease in contraction velocity to obvious impairment of voiding function. Urology. 2008;71(5):844–8. https://doi.org/10.1016/j.urology.2007.11.145.
Smith PP, Chalmers DJ, Feinn RS. Does defective volume sensation contribute to detrusor underactivity? Neurourol Urodyn. 2015;34:752–6. https://doi.org/10.1002/nau.22653.
Jiang YH, Kuo HC. Urothelial barrier deficits, suburothelial inflammation and altered sensory protein expression in detrusor underactivity. J Urol. 2017;197:197–203. https://doi.org/10.1016/j.juro.2016.07.071.
Yang TH, Chuang FC, Kuo HC. Urodynamic characteristics of detrusor underactivity in women with voiding dysfunction. PLoS One. 2018;13:e0198764. https://doi.org/10.1371/journal.pone.0198764.
Resnick NA, Yalla SV. Detrusor hyperactivity with impaired contractile function. An unrecognized but common cause of incontinence in elderly patients. JAMA. 1987;257:3076–81.
Wagg A, Chen LK, Johnson T, Kirschner-Hermanns R, Kuchel G, Markland A, et al. Incontinence in frail older persons. In: Abrams P, Cardozo L, Wagg A, Wien A, editors. Incontinence. 6th ed. Tokyo: ICUD and ICS; 2016. p. 1309–441.
Gammie A, Kaper M, Steup A, Yoshida S, Dorrepaal C, Kos T, et al. What are the additional signs and symptoms in patients with detrusor underactivity and coexisting detrusor overactivity? Neurourol Urodyn. 2018;37:2220–5. https://doi.org/10.1002/nau.23565.
Stav K, Shilo Y, Zisman A, Lindner A, Leibovici D. Comparison of lower urinary tract symptoms between women with detrusor overactivity and impaired contractility, and detrusor overactivity and preserved contractility. J Urol. 2013;189:2175–8. https://doi.org/10.1016/j.juro.2012.11.178.
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Natale, F., Trama, F. (2021). Diagnosis of Underactive Bladder in Female. In: Balzarro, M., Li Marzi, V. (eds) Non-Neurogenic Bladder Dysfunctions. Urodynamics, Neurourology and Pelvic Floor Dysfunctions. Springer, Cham. https://doi.org/10.1007/978-3-030-57393-5_10
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DOI: https://doi.org/10.1007/978-3-030-57393-5_10
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