Abstract
Molecular communication (MC) holds considerable promise as the next generation of design for drug delivery that allows for targeted therapy with minimal toxicity. Most current studies on flow-based MC driven drug delivery application consider a Newtonian fluid and laminar flow. However, blood is a complex biological fluid composed of deformable cells especially red blood cells, proteins, platelets, and plasma. For blood flow in capillaries, arterioles and venules, the particulate nature of the blood needs to be considered in the delivery process. The ability to change shape is essential for the proper functioning of red blood cells in microvessels. The different shapes of red blood cells have a great impact on the performance characteristics of whole blood (blood and plasma). Changes in the properties and shape of RBC substances are often associated with different blood diseases and diseases, such as sickle cell anemia, diabetes, and malaria. Based on the state of the red blood cells in the microtubules at different flow rates, this paper proposes a design for detecting the ability of the cells to deform. Based on the difference in the concentration of the nanoparticles at the receiving end at different flow rates, the ability of the red blood cells to deform is determined, and the blood state is determined. Further, the related blood diseases can be initially predicted.
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Zhang, R., Sun, Y., Chen, Y. (2020). Design for Detecting Red Blood Cell Deformation at Different Flow Velocities in Blood Vessel. In: Chen, Y., Nakano, T., Lin, L., Mahfuz, M., Guo, W. (eds) Bio-inspired Information and Communication Technologies. BICT 2020. Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, vol 329. Springer, Cham. https://doi.org/10.1007/978-3-030-57115-3_20
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DOI: https://doi.org/10.1007/978-3-030-57115-3_20
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