Abstract
Adverse childhood experiences (ACEs) are widely recognized as predictors of early onset of alcohol and other drug use, problematic substance use, and addiction (Anda et al., Eur Arch Psych Clin Neurosci 256(3):174–186, 2006; Campbell et al., Am J Prev Med 50(3):344–352, 2016; Merrick et al., J Am Med Assoc Pediat 172:1038–1044, 2018). ACEs can have profound and enduring effects on neurological development, and immune and metabolic systems, resulting in behavioral and epigenetic changes that can persist across generations. Research with animal models and humans indicates that early exposure to abuse, neglect, and other stressors alters brain development, decreasing the individual’s ability and capacity to manage stress and emotions and increasing the likelihood of dependence on mood-altering substances (Kirsch et al., Adver Resil Sci, 1–19, 2020). There are growing bodies of evidence that environments enriched in nurturing relationships and resources can buffer the effects of early adversity (Blaze and Roth 2015; Morris et al. 2018). Interventions such as Attachment Biobehavioral Catch-up (ABC) that promote secure attachment show promise for interrupting the intergenerational cycle of adversity and addiction. Policies and programs that ensure access to Protective and Compensatory Experiences (PACEs) may also promote resilience in families who have experienced ACEs and addiction (Hays-Grudo and Morris, Adverse and protective childhood experiences: A developmental perspective. American Psychological Association, Washington, DC, 2020).
Keywords
- Adversity
- Resilience
- Adverse Childhood Experiences (ACEs)
- Protective and Compensatory Experiences (PACEs)
- Addiction
- Attachment
- Stress
Preparation of this chapter was supported by a Centers of Biomedical Research Excellence grant (P20GM199097, PD: Jennifer Hays-Grudo; National Institutes of Health) and 3/6 Planning for the HEALthy Early Development Study (R34DA050237; MPIs: Julie M. Croff & Amanda S. Morris).
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References
Ainsworth, M. D. S. (1973). The development of mother-infant attachment. Review of Child Development Research, 3, 1–94.
Allem, J. P., Soto, D. W., Baezconde-Garbanati, L., & Unger, J. B. (2015). Adverse childhood experiences and substance use among Hispanic emerging adults in Southern California. Addictive Behaviors, 50, 199–204.
Anda, R. F., Felitti, V. J., Bremner, J. D., Walker, J. D., Whitfield, C., Perry, B. D., et al. (2006). The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology. European Archives of Psychiatry and Clinical Neuroscience, 256(3), 174–186. https://doi.org/10.1007/s00406-005-0624-4.
Anda, R. F., Porter, L. E., & Brown, D. W. (2020). Inside the adverse childhood experience score: Strengths, limitations, and misapplications. American Journal of Preventive Medicine, 59(2), 293−295.
Ball, G., Stokes, P. R., Rhodes, R. A., Bose, S. K., Rezek, I., Wink, A.-M., & Turkheimer, F. E. (2011). Executive functions and prefrontal cortex: A matter of persistence? Frontiers in Systems Neuroscience, 5(3), 1–13.
Barch, D. M., Belden, A. C., Tillman, R., Whalen, D., & Luby, J. L. (2018). Early childhood adverse experiences, inferior frontal gyrus connectivity, and the trajectory of externalizing psychopathology. Journal of the American Academy of Child & Adolescent Psychiatry, 57(3), 183–190.
Bernard, K., Butzin-Dozier, Z., Rittenhouse, J., & Dozier, M. (2010). Cortisol production patterns in young children living with birth parents vs children placed in foster care following involvement of Child Protective Services. Archives of Pediatrics and Adolescent Medicine, 164, 438–443.
Bernard, K., Dozier, M., Bick, J., Lewis-Morrarty, E., Lindhiem, O., & Carlson, E. (2012). Enhancing attachment organization among maltreated infants: Results of a randomized clinical trial. Child Development, 83, 623–636.
Bernard, K., Hostinar, C. E., & Dozier, M. (2015). Intervention effects on diurnal cortisol rhythms of CPS-referred infants persist into early childhood: Preschool follow-up results of a randomized clinical trial. JAMA-Pediatrics, 169, 112–119.
Bick, J., & Dozier, M. (2013). The effectiveness of an attachment-based intervention in promoting foster mothers’ sensitivity toward foster infants. Infant Mental Health Journal, 34, 95–103.
Bick, J., Palmwood, E., Zajac, L., Simons, R. F., & Dozier, M. (2019). Early prevention and adverse environments affect neural functioning in middle childhood. Biological Psychiatry, 85, 326–335.
Black, D. S. (2014). Mindfulness-based interventions: An antidote to suffering in the context of substance use, misuse, and addiction. Substance Use & Misuse, 49(5), 487–491.
Bonn-Miller, M. O., Zvolensky, M. J., Marshall, E. C., & Bernstein, A. (2007). Incremental validity of anxiety sensitivity in relation to marijuana withdrawal symptoms. Addictive Behaviors, 32(9), 1843–1851.
Bowen, S., Witkiewitz, K., Clifasefi, S. L., Grow, J., Chawla, N., Hsu, S. H., et al. (2014). Relative efficacy of mindfulness-based relapse prevention, standard relapse prevention, and treatment as usual for substance use disorders: A randomized clinical trial. JAMA Psychiatry, 71(5), 547–556.
Blaze, J., & Roth, T. L. (2015, July). Evidence from clinical and animal model studies of the long-term and transgenerational impact of stress on DNA methylation. In Seminars in cell & developmental biology (Vol. 43, pp. 76–84). Academic Press.
Caldwell, J. G., Shaver, P. R., Li, C.-S., & Minzenberg, M. J. (2011). Childhood maltreatment, adult attachment, and depression as predictors of parental self-efficacy in at-risk mothers. Journal of Aggression, Maltreatment & Trauma, 20(6), 595–616. https://doi.org/10.1080/10926771.2011.595763.
Campbell, J. A., Walker, R. J., & Egede, L. E. (2016). Associations between adverse childhood experiences, high-risk behaviors, and morbidity in adulthood. American Journal of Preventative Medicine, 50(3), 344–352. https://doi.org/10.1016/j.amepre.2015.07.022.
Caron, E., Bernard, K., & Dozier, M. (2018). In-vivo feedback predicts behavioral change in the attachment and biobehavioral catch-up intervention. Journal of Clinical Child and Adolescent Psychology, 47, S35–S46.
Chu, D. A., Williams, L. M., Harris, A. W., Bryant, R. A., & Gatt, J. M. (2013). Early life trauma predicts self-reported levels of depressive and anxiety symptoms in nonclinical community adults: Relative contributions of early life stressor types and adult trauma exposure. Journal of Psychiatric Research, 47(1), 23–32.
Cleveland, H., Brick, T., Knapp, K., & Croff, J. (2020). Recovery & recovery capital: Aligning measurement with theory and practice. In J. Croff & J. Beaman (Eds.), Family resilience and recovery: Opioids and other addictions. Springer. Manuscript submitted for publication.
Cook, A., Spinazzola, J., Ford, J., Lanktree, C., Blaustein, M., Cloitre, M., et al. (2017). Complex trauma in children and adolescents. Psychiatric Annals, 35(5), 390–398.
Crittenden, P. M., & Landini, A. (2011). Assessing adult attachment: A dynamic-maturational approach to discourse analysis. New York/London: WW Norton & Company.
Davis, M., Walker, D. L., Miles, L., & Grillon, C. (2010). Phasic vs sustained fear in rats and humans: Role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology, 35(1), 105–135.
Dozier, M., Stovall, K. C., Albus, K. E., & Bates, B. (2001). Attachment for infants in foster care: The role of caregiver state of mind. Child Development, 72, 1467–1477.
Dube, S. R., Anda, R. F., Felitti, V. J., Croft, J. B., Edwards, V. J., & Giles, W. H. (2001). Growing up with parental alcohol abuse: Exposure to childhood abuse, neglect, and household dysfunction. Child Abuse & Neglect, 25(12), 1627–1640.
Dube, S. R., Felitti, V. J., Dong, M., Chapman, D. P., Giles, W. H., & Anda, R. F. (2003). Childhood abuse, neglect, and household dysfunction and the risk of illicit drug use: The adverse childhood experiences study. Pediatrics, 111(3), 564–572.
Duncan, G. J., & Brooks-Gunn, J. (2000). Family poverty, welfare reform, and child development. Child Development, 71(1), 188–196.
Espeleta, H. C., Palasciano-Barton, S., & Messman-Moore, T. L. (2017). The impact of child abuse severity on adult attachment anxiety and avoidance in college women: The role of emotion dysregulation. Journal of Family Violence, 32, 399–407. https://doi.org/10.1007/s10896-016-9816-0.
Fairbairn, C. E., Briley, D. A., Kang, D., Fraley, R. C., Hankin, B. L., & Ariss, T. (2018). A meta-analysis of longitudinal associations between substance use and interpersonal attachment security. Psychological Bulletin, 144(5), 532.
Fareri, D. S., & Tottenham, N. (2016). Effects of early life stress on amygdala and striatal development. Developmental Cognitive Neuroscience, 19, 233–247.
Frodl, T., Schaub, A., Banac, S., Charypar, M., Jäger, M., Kümmler, P., et al. (2006). Reduced hippocampal volume correlates with executive dysfunctioning in major depression. Journal of Psychiatry and Neuroscience, 31(5), 316.
Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., & Marks, J. S. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine, 14(4), 245–258.
Geuze, E. E. J. D., Vermetten, E., & Bremner, J. D. (2005). MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders. Molecular Psychiatry, 10(2), 160–184.
Gotink, R. A., Meijboom, R., Vernooij, M. W., Smits, M., & Hunink, M. M. (2016). 8-week mindfulness based stress reduction induces brain changes similar to traditional long-term meditation practice–a systematic review. Brain and Cognition, 108, 32–41.
Hatchard, T., Mioduszewski, O., Zambrana, A., O’Farrell, E., Caluyong, M., Poulin, P. A., & Smith, A. M. (2017). Neural changes associated with mindfulness-based stress reduction (mbsr): Current knowledge, limitations, and future directions. Psychology & Neuroscience, 10(1), 41.
Hays-Grudo, J., & Morris, A. S. (2020). Adverse and protective childhood experiences: A developmental perspective. Washington, DC: American Psychological Association.
Heim, C., & Nemeroff, C. B. (2001). The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies. Biological Psychiatry, 49(12), 1023–1039.
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008). The link between childhood trauma and depression: Insights from HPA axis studies in humans. Psychoneuroendocrinology, 33(6), 693–710.
Henry, C. S., Sheffield Morris, A., & Harrist, A. W. (2015). Family resilience: Moving into the third wave. Family Relations, 64(1), 22–43.
Hertzman, C. (2012). Putting the concept of biological embedding in historical perspective. Proceedings of the National Academy of Sciences. 201202203.
Kabat-Zinn, J. (2005). Coming to our senses: Healing ourselves and the world through mindfulness. New York: Hachette UK.
Kalivas, P. W., & Volkow, N. D. (2005). The neural basis of addiction: A pathology of motivation and choice. The American Journal of Psychiatry, 162(8), 1403–1413.
Kim, S., Iyengar, U., Mayes, L. C., Potenza, M. N., Rutherford, H. J., & Strathearn, L. (2017). Mothers with substance addictions show reduced reward responses when viewing their own infant’s face. Human Brain Mapping, 38(11), 5421–5439.
Kirsch, D., Nemeroff, C. M., & Lippard, E. T. (2020). Early life stress and substance use disorders: Underlying neurobiology and pathways to adverse outcomes. Adversity and Resilience Science, 1–19.
Laine, T. P. J., Ahonen, A., Räsänen, P., & Tiihonen, J. (1999). Dopamine transporter availability and depressive symptoms during alcohol withdrawal. Psychiatry Research: Neuroimaging, 90(3), 153–157.
Loudermilk, E., Loudermilk, K., Obenauer, J., & Quinn, M. A. (2018). Impact of adverse childhood experiences (ACEs) on adult alcohol consumption behaviors. Child Abuse & Neglect, 86, 368–374.
Luby, J. L., Barch, D., Whalen, D., Tillman, R., & Belden, A. (2017). Association between early life adversity and risk for poor emotional and physical health in adolescence: A putative mechanistic neurodevelopmental pathway. JAMA Pediatrics, 171(12), 1168–1175.
Luthar, S. S., Cicchetti, D., & Becker, B. (2000). The construct of resilience: A critical evaluation and guidelines for future work. Child Development, 71(3), 543–562.
Main, M., & Hesse, E. (1990). Parents’ unresolved traumatic experiences are related to infant disorganized attachment status: Is frightened and/or frightening parental behavior the linking mechanism? In M. T. Greenberg, D. Cicchetti, & E. Cummings (Eds.), Attachment in the preschool years: Theory, research, and intervention (pp. 161–182). Chicago: University of Chicago Press.
Masten, A. S. (2014). Global perspectives on resilience in children and youth. Child Development, 85(1), 6–20.
McEwen, B. S. (1998). Protective and damaging effects of stress mediators. New England Journal of Medicine, 338(3), 171–179. https://doi.org/10.1056/NEJM199801153380307.
McEwen, B. S. (2003). Interacting mediators of allostasis and allostatic load: Towards an understanding of resilience in aging. Metabolism, 52, 10–16.
McLoyd, V. C. (1998). Socioeconomic disadvantage and child development. American Psychologist, 53(2), 185.
Merrick, M. T., Ford, D. C., Ports, K. A., & Guinn, A. S. (2018). Prevalence of adverse childhood experiences from the 2011–2014 behavioral risk factor surveillance system in 23 states. Journal of the American Medical Association Pediatrics, 172, 1038–1044.
Mersky, J. P., Topitzes, J., & Reynolds, A. J. (2013). Impacts of adverse childhood experiences on health, mental health, and substance use in early adulthood: A cohort study of an urban, minority sample in the US. Child Abuse & Neglect, 37(11), 917–925.
Morris, A. S., Treat, A. E., Hays-Grudo, J., Chesher, T., Williamson, A. C., & Mendez, J. (2018). Integrating research and theory on early relationships to guide intervention and prevention. In A. S. Morris & A. C. Williamson (Eds.), Building early social and emotional relationships with infants and toddlers (pp. 1–26). Cham: Springer.
Morris, A. S., & Hays-Grudo, J. (2014). Protecting parents and children from Adverse Childhood Experiences (ACEs): Preliminary evidence for the validity of the PACEs (with Amanda Morris). In: Paper presented at the SRCD special topic meeting: New conceptualizations in the study of parenting-at-risk, San Diego.
Nelson, C. A. (2013). Biological embedding of early life adversity. The Journal of the American Medical Association Pediatrics, 167(12), 1098–1100.
Pechtel, P., & Pizzagalli, D. A. (2011). Effects of early life stress on cognitive and affective function: An integrated review of human literature. Psychopharmacology, 214(1), 55–70.
Riem, M. M., Alink, L. R., Out, D., Van Ijzendoorn, M. H., & Bakermans-Kranenburg, M. J. (2015). Beating the brain about abuse: Empirical and meta-analytic studies of the association between maltreatment and hippocampal volume across childhood and adolescence. Development and Psychopathology, 27(2), 507–520.
Riggs, S. A., & Kaminski, P. (2010). Childhood emotional abuse, adult attachment, and depression as predictors of relational adjustment and psychological aggression. Journal of Aggression, Maltreatment & Trauma, 19(1), 75–104.
Roelofs, S. M. (1985). Hyperventilation, anxiety, craving for alcohol: A subacute alcohol withdrawal syndrome. Alcohol, 2(3), 501–505.
Rothman, E. F., Edwards, E. M., Heeren, T., & Hingson, R. W. (2008). Adverse childhood experiences predict earlier age of drinking onset: Results from a representative US sample of current or former drinkers. Pediatrics, 122(2), e298–e304.
Rutter, M. (1987). Psychosocial resilience and protective mechanisms. American Journal of Orthopsychiatry, 57(3), 316–331.
Shin, S. H., Edwards, E. M., & Heeren, T. (2009). Child abuse and neglect: Relations to adolescent binge drinking in the national longitudinal study of adolescent health (AddHealth) study. Addictive Behaviors, 34(3), 277–280.
Shonkoff, J. P. (2010). Building a new biodevelopmental framework to guide the future of early childhood policy. Child Development, 81(1), 357–367.
Somer, E. (2003). Prediction of abstinence from heroin addiction by childhood trauma, dissociation, and extent of psychosocial treatment. Addiction Research & Theory, 11(5), 339–348. https://doi.org/10.1080/1606635031000141102.
Strathearn, L., Mertens, C. E., Mayes, L., Rutherford, H., Rajhans, P., Xu, G., Potenza, M. N., & Kim, S. (2019). Pathways relating the neurobiology of attachment to drug addiction. Frontiers in Psychiatry, 10, 737.
Strine, T. W., Dube, S. R., Edwards, V. J., Prehn, A. W., Rasmussen, S., Wagenfeld, M., et al. (2012). Associations between adverse childhood experiences, psychological distress, and adult alcohol problems. American Journal of Health Behavior, 36(3), 408–423.
Swartz, J. R., Knodt, A. R., Radtke, S. R., & Hariri, A. R. (2015). A neural biomarker of psychological vulnerability to future life stress. Neuron, 85(3), 505–511.
Sterling, P., & Eyer, J. (1988). Allostasis; A new paradigm to rxplain srousal pathology. In: S. Fisher, S. & J. Reason, Eds. Handbook of Life Stress, Cognition and Health (PP. 629–649). New York: Wiley.
Tabachnick, A., Raby, K. L., Goldstein, A., Zajac, L., & Dozier, M. (2019). Effects of an attachment-based intervention on children’s autonomic regulation during middle childhood. Biological Psychology, 143, 22–31.
Tang, Y. Y., Holzel, B. K., & Posner, M. I. (2015). The neuroscience of mindfulness meditation. Nature Reviews Neuroscience, 16(4), 213–225. https://doi.org/10.1038/nrn3916.
Teicher, M. H., & Samson, J. A. (2016). Annual research review: Enduring neurobiological effects of childhood abuse and neglect. Journal of Child Psychology and Psychiatry, 57(3), 241–266. https://doi.org/10.1111/jcpp.12507.
Teicher, M. H., Samson, J. A., Anderson, C. M., & Ohashi, K. (2016). The effects of childhood maltreatment on brain structure, function and connectivity. Nature Reviews Neuroscience, 17(10), 652.
Thomason, M. E., & Marusak, H. A. (2017). Toward understanding the impact of trauma on the early developing human brain. Neuroscience, 342, 55–67.
United Hospital Fund. (2019). The ripple effect: Nation and state estimates of the US Opioid epidemics effect on children.
van Harmelen, A. L., van Tol, M. J., van der Wee, N. J., Veltman, D. J., Aleman, A., Spinhoven, P., et al. (2010). Reduced medial prefrontal cortex volume in adults reporting childhood emotional maltreatment. Biological Psychiatry, 68(9), 832–838.
van Harmelen, A. L., van Tol, M. J., Dalgleish, T., van der Wee, N. J., Veltman, D. J., Aleman, A., et al. (2014). Hypoactive medial prefrontal cortex functioning in adults reporting childhood emotional maltreatment. Social Cognitive and Affective Neuroscience, 9(12), 2026–2033.
Van der Kolk, B. A. (2003). The neurobiology of childhood trauma and abuse. Child and Adolescent Psychiatric Clinics, 12(2), 293–317.
Wade, R., Jr., Shea, J. A., Rubin, D., & Wood, J. (2014). Adverse childhood experiences of low-income urban youth. Pediatrics, 134(1), e13–e20. https://doi.org/10.1542/peds.2013-2475.
Young, E. (2017). How Iceland got teens to say no to drugs. The Atlantic, 1–15.
Young, S. Y., Hansen, C. J., Gibson, R. L., & Ryan, M. A. (2006). Risky alcohol use, age at onset of drinking, and adverse childhood experiences in young men entering the US Marine Corps. Archives of Pediatrics & Adolescent Medicine, 160(12), 1207–1214.
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Questions for Thought and Discussion
Questions for Thought and Discussion
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1.
Think about the concept of “adaptation.” How can biological and behavioral adaptations to threatening or dangerous experience during childhood have long-term maladaptive consequences? How would the prevention and treatment of substance use disorders be different if it is thought of as short-term adaptations with long-term consequences?
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2.
Develop a research question based on one of the assertions made in this chapter, (e.g., that mindfulness practice can reduce substance abuse in teens by improving deficits in executive function skills resulting from ACEs) and design an intervention study to examine it. Include in your research design qualitative as well as quantitative measures to assess the effects of the intervention.
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3.
The authors propose that clinical practitioners and policy makers should consider the importance of providing enriched environments and supportive relationships for at-risk children and their families. Select five of the PACEs that could be made more accessible to families through existing health care systems, social services, educational systems, or philanthropic programs.
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4.
Write a letter to the editor of your local newspaper that describes in everyday language the link between ACEs and addiction, including the biological and behavioral effects on child development, the evidence-based programs that can interrupt the cycle of adversity and addition, and why the community would benefit from making such programs more available.
Glossary of Terms
- Addiction
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a brain disease whose visible symptoms are behaviors
- Adversity
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a host of experiences that can cause serious or chronic stress.
- Attachment
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an emotional bond that connects one person to another
- Adverse Childhood Experiences (ACEs)
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ten potentially traumatic events that occur in childhood (verbal abuse, physical abuse, sexual abuse, physical neglect, emotional neglect, witness interpersonal violence, substance abuse in home, separated/divorced parents, family member incarcerated, family member mentally ill or suicidal)
- Protective and Compensatory Experiences (PACEs)
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ten environmental characteristics that appear to buffer children from the effects of parental substance abuse and other ACEs and may be helpful to adults working to overcome the effects of their own adverse childhoods and subsequent substance use
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Hays-Grudo, J., Morris, A.S., Ratliff, E.L., Croff, J.M. (2021). Adverse Childhood Experiences and Addiction. In: Croff, J.M., Beaman, J. (eds) Family Resilience and Recovery from Opioids and Other Addictions. Emerging Issues in Family and Individual Resilience. Springer, Cham. https://doi.org/10.1007/978-3-030-56958-7_5
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