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The Ethical Challenges of Stem Cell Therapy in Vascular Disorders

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Stem Cell Therapy for Vascular Diseases

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Abstract

Most ethical conflicts in clinical medicine are resolvable with the foundational basic principles of bioethics, i.e. autonomy, beneficence, non-maleficence, and justice. However, the modern medicine is continuously evolving, and in doing so asks challenging questions not just scientifically, but also deeply probes the far-reaching depths of bioethics, generating political, religious, and cultural controversies. Stem cell research, the latest in therapeutic advancements of modern medicine has demonstrated immense potential in laboratory experiments and clinical applications, but these successes have unearthed highly controversial debates on “personhood” and the criteria that would define a human being besides the biological concept. The futuristic potential of stem cell research although marks an exciting phase for scientists, yet horrifies the philosophers, religious thinkers and ethicists about the birth, existence, and proliferation of human clones and chimera. Thus, the inevitable clash between science, ethics, and religion opens the portal to political controversies. This chapter herein will provide the readers an opportunity to reflect on different viewpoints to the argument and ethical debate in stem cell research with special attention to the therapeutic applications in vascular disorders of limbs and myocardial ischemia related disorders.

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References

  1. Adams B, Xiao Q, Xu Q. Stem cell therapy for vascular disease. Trends Cardiovasc Med. 2007;17(7):246–51.

    Article  CAS  Google Scholar 

  2. Mauritz C, Schwanke K, Reppel M, Neef S, Katsirntaki K, Maier LS, et al. Generation of functional murine cardiac myocytes from induced pluripotent stem cells. Circulation. 2008;118(5):507–17.

    Article  Google Scholar 

  3. The President’s Council on Bioethics Human cloning and human dignity: an ethical inquiry. Washington, DC. US Government Printing Office, 2002.

    Google Scholar 

  4. Brock DW. Is a consensus possible on stem cell research? Moral and political obstacles. J Med Ethics. 2006;32(1):36–42.

    Article  CAS  Google Scholar 

  5. Warren M. Moral Status: Obligations to Persons and Other Living Things. Oxford University Press (2000). Retrieved 22 Nov 2019, from https://www.oxfordscholarship.com/view/10.1093/acprof:oso/9780198250401.001.0001/acprof-9780198250401.

  6. Orr R. The moral status of the embryonal stem cell: inherent or imputed? Am J Bioethics 2002;2(1):57–9.

    Google Scholar 

  7. Hudson K, Scott J, Faden R. Values in conflict: Public attitudes on embryonic stem cell research: Genetic and Public Policy Center, 2005.

    Google Scholar 

  8. Wolinsky H. The pendulum swung. President Barack Obama removes restrictions on stem-cell research, but are expectations now too high? EMBO Rep. 2009;10(5):436–9.

    Article  CAS  Google Scholar 

  9. Lyerly AD, Faden RR. Willingness to donate frozen embryos for stem cell research. Science. 2007;317(5834):46–7.

    Article  Google Scholar 

  10. Lyerly AD, Steinhauser K, Namey E, Tulsky JA, Cook-Deegan R, Sugarman J, et al. Factors that affect infertility patients’ decisions about disposition of frozen embryos. Fertil Steril. 2006;85(6):1623–30.

    Article  Google Scholar 

  11. National Bioethics Advisory Commission. Research involving human biological materials: ethical issues and policy guidance vRMNBAC. 1999.

    Google Scholar 

  12. Lo B, Chou V, Cedars MI, Gates E, Taylor RN, Wagner RM, et al. Informed consent in human oocyte, embryo, and embryonic stem cell research. Fertil Steril. 2004;82(3):559–63.

    Article  Google Scholar 

  13. Lo B, Parham L. Ethical issues in stem cell research. Endocr Rev. 2009;30(3):204–13.

    Article  Google Scholar 

  14. Kalfoglou AL, Geller G. A follow-up study with oocyte donors exploring their experiences, knowledge, and attitudes about the use of their oocytes and the outcome of the donation. Fertil Steril. 2000;74(4):660–7.

    Article  CAS  Google Scholar 

  15. National Research Council and Institute of Medicine. Guidelines for human embryonic stem cell research. Washington DCNAP. 2005.

    Google Scholar 

  16. Hwang WS, Roh SI, Lee BC, Kang SK, Kwon DK, Kim S, et al. Patient-specific embryonic stem cells derived from human SCNT blastocysts. Science. 2005;308(5729):1777–83.

    Article  CAS  Google Scholar 

  17. National Bioethics Committee, Republic of Korea. The National Bioethics Committee’s report on bioethical problems in Hwang Woo-Suk research, Seoul: Bioethics Policy and Research Center, 2006.

    Google Scholar 

  18. Clay AS. Hwang Woo-suk’s Use of Human Eggs for Research 2002–2005. Embryo Project Encyclopedia (2014-08-12) ISSN: 1940–5030. http://www.embryo.asu.edu/handle/10776/8145.

  19. Golan A, Ron-el R, Herman A, Soffer Y, Weinraub Z, Caspi E. Ovarian hyperstimulation syndrome: an update review. Obstet Gynecol Surv. 1989;44(6):430–40.

    Article  CAS  Google Scholar 

  20. Schenker JG, Weinstein D. Ovarian hyperstimulation syndrome: a current survey. Fertil Steril. 1978;30(3):255–68.

    Article  CAS  Google Scholar 

  21. Cluroe AD, Synek BJ. A fatal case of ovarian hyperstimulation syndrome with cerebral infarction. Pathology. 1995;27(4):344–6.

    Article  CAS  Google Scholar 

  22. Semba S, Moriya T, Youssef EM, Sasano H. An autopsy case of ovarian hyperstimulation syndrome with massive pulmonary edema and pleural effusion. Pathol Int. 2000;50(7):549–52.

    Article  CAS  Google Scholar 

  23. Ward R, Krugman S, Giles JP, Jacobs AM, Bodansky O. Infectious hepatitis; studies of its natural history and prevention. N Engl J Med. 1958;258(9):407–16.

    Article  CAS  Google Scholar 

  24. Krugman S, Ward R, Giles JP, Bodansky O, Jacobs AM. Infectious hepatitis: detection of virus during the incubation period and in clinically inapparent infection. N Engl J Med. 1959;261:729–34.

    Article  CAS  Google Scholar 

  25. World Medical Association (WMA). 1964 Declaration of Helsinki. Amended by the WMA 52nd General Assembly 2000, Edinburgh.

    Google Scholar 

  26. Ballantyne A, de Lacey S. Wanted—egg donors for research: a research ethics approach to donor recruitment and compensation. Int J Feminist Appr Bioeth. 2008;1(2):145–64.

    Article  Google Scholar 

  27. Pearson H. Health effects of egg donation may take decades to emerge. Nature. 2006;442(7103):607–8.

    Article  CAS  Google Scholar 

  28. Klitzman R, Sauer MV. Payment of egg donors in stem cell research in the USA. Reprod Biomed Online. 2009;18(5):603–8.

    Article  Google Scholar 

  29. National Academy of Sciences. The National Academies’ guidelines for human embryonic stem cell research. The National Academies Press; Washington, DC: 2005 Available at: http://www.nap.edu/catalog/11278.html.

  30. National Academy of Sciences. Amendments to the National Academies’ guidelines for human embryonic stem cell research. The National Academies Press; Washington, DC: 2007 Available at: http://www.books.nap.edu/catalog.php?record_id=11871#toc.

  31. National Academy of Sciences. Amendments to the National Academies’ guidelines for human embryonic stem cell research. The National Academies Press; Washington, DC: 2008 Available at http://www.nap.edu/catalogphp?record_id=12260.

  32. California Institute for Regenerative Medicine. Guidance for CIRM medical and ethical standards regulations governing donation of oocytes for CIRM-funded research. 2008. Available at: http://www.cirm.ca.gov/workgroups/pdf/Guidance_Donation_Oocytes.pdf.

  33. Beeson D, Lippman A. Egg harvesting for stem cell research: medical risks and ethical problems. Reprod Biomed Online. 2006;13(4):573–9.

    Article  Google Scholar 

  34. BBC News 2006. Available at: http://www.news.bbc.co.uk/2/hi/europe/6171083.stm.

  35. Camporesi S, Boniolo G. Fearing a non-existing Minotaur? The ethical challenges of research on cytoplasmic hybrid embryos. J Med Ethics. 2008;34(11):821–5.

    Article  CAS  Google Scholar 

  36. Milliez J. Ethical guidelines concerning cytoplasmic animal–human hybrid embryos. Int J Gynecol Obstet. 2009;107(2):167.

    Article  Google Scholar 

  37. Beyhan Z, Iager AE, Cibelli JB. Interspecies nuclear transfer: implications for embryonic stem cell biology. Cell Stem Cell. 2007;1(5):502–12.

    Article  CAS  Google Scholar 

  38. Leeper NJ, Hunter AL, Cooke JP. Stem cell therapy for vascular regeneration: adult, embryonic, and induced pluripotent stem cells. Circulation. 2010;122(5):517–26.

    Article  Google Scholar 

  39. Narazaki G, Uosaki H, Teranishi M, Okita K, Kim B, Matsuoka S, et al. Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation. 2008;118(5):498–506.

    Article  Google Scholar 

  40. Yamahara K, Sone M, Itoh H, Yamashita JK, Yurugi-Kobayashi T, Homma K, et al. Augmentation of neovascularization [corrected] in hindlimb ischemia by combined transplantation of human embryonic stem cells-derived endothelial and mural cells. PLoS One. 2008;3(2):e1666.

    Article  Google Scholar 

  41. Li Z, Wu JC, Sheikh AY, Kraft D, Cao F, Xie X, et al. Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease. Circulation. 2007;116(11 Suppl):I46–54.

    PubMed  PubMed Central  Google Scholar 

  42. Okawa T, Kamiya H, Himeno T, Kato J, Seino Y, Fujiya A, et al. Transplantation of neural crest-like cells derived from induced pluripotent stem cells improves diabetic polyneuropathy in mice. Cell Transplant. 2013;22(10):1767–83.

    Article  Google Scholar 

  43. President’s Council on Bioethics (US). Alternative sources of human pluripotent stem cells: a white paper of the President’s Council on Bioethics. President’s Council on Bioethics, 2005.

    Google Scholar 

  44. Chen L, Mizutani A, Kasai T, Yan T, Jin G, Vaidyanath A, et al. Mouse induced pluripotent stem cell microenvironment generates epithelial-mesenchymal transition in mouse Lewis lung cancer cells. Am J Cancer Res. 2014;4(1):80–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  45. Kou Z, Kang L, Yuan Y, Tao Y, Zhang Y, Wu T, et al. Mice cloned from induced pluripotent stem cells (iPSCs). Biol Reprod. 2010;83(2):238–43.

    Article  CAS  Google Scholar 

  46. Frazzetto G. Embryos, cells and god. EMBO Rep. 2004;5(6):553–5.

    Article  CAS  Google Scholar 

  47. Bruce DM. Stem cells, embryos and cloning–unravelling the ethics of a knotty debate. J Mol Biol. 2002;319(4):917–25.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Yale School of Medicine, Yale University, Yale New Haven Transplant Center, New Haven, CT, USA

    Ramesh K. Batra

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  1. Ramesh K. Batra
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Correspondence to Ramesh K. Batra .

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Editors and Affiliations

  1. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  2. Postgraduate Program in Sciences Applied to Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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Batra, R.K. (2021). The Ethical Challenges of Stem Cell Therapy in Vascular Disorders. In: Navarro, T.P., Minchillo Lopes, L.L.N., Dardik, A. (eds) Stem Cell Therapy for Vascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-56954-9_4

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  • DOI: https://doi.org/10.1007/978-3-030-56954-9_4

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-56953-2

  • Online ISBN: 978-3-030-56954-9

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