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Stem Cell Therapy for Ophthalmic Vascular Disease

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Stem Cell Therapy for Vascular Diseases

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Abstract

Stem cell therapy has the potential to improve the natural history of several retinal degenerative diseases. Treatments based on cell regeneration, and or replacement, has transformative scientific potential in the management of some of the most devastating ocular diseases, including some that currently have no curative treatment. Two mechanisms of action have been proposed: regenerative or trophic. Currently there are no FDA-approved stem cell therapies for retinal disease. At present more than 50 stem/progenitor cell therapy trials for retinal disease are listed on the www.clinicaltrials.gov website. These studies use three sources of cells: pluripotent, fetal, and postnatal (“adult stem cells”). In this chapter we summarize key concepts, as well as early safety and efficacy signals from clinical trials, for stem/progenitor cell-based interventions for retinal disease.

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Authors and Affiliations

  1. Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil

    Caio Vinicius Regatieri & Augusto Vieira

  2. Department of ophthalmology, Tufts Medical School, Boston, MA, USA

    Caio Vinicius Regatieri

  3. Department of Ophthalmology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil

    Marcio Bittar Nehemy

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  1. Caio Vinicius Regatieri
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  2. Augusto Vieira
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  3. Marcio Bittar Nehemy
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Editors and Affiliations

  1. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  2. Postgraduate Program in Sciences Applied to Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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Regatieri, C.V., Vieira, A., Nehemy, M.B. (2021). Stem Cell Therapy for Ophthalmic Vascular Disease. In: Navarro, T.P., Minchillo Lopes, L.L.N., Dardik, A. (eds) Stem Cell Therapy for Vascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-56954-9_17

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