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Introduction to Stem Cell Therapy and Its Application in Vascular Diseases

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Stem Cell Therapy for Vascular Diseases

Abstract

Stem cell therapy has recently emerged as an innovative therapeutic strategy for various vascular diseases. Stem cell therapy comprises a spectrum of cell-based regenerative strategies characterized by three sets of variables: (1) stem cell intrinsic properties (origin, type, isolation/induction, culture, and priming features); (2) therapy protocol (dose, concentration, administration route, adjuvants); and (3) patient characteristics (medical history, immune reaction, disease of interest). In this chapter, we introduce basic concepts regarding stem cell therapy: stem cell types and origin, mechanisms of regeneration, isolation, cell culture and priming, administration routes, and therapeutic risks. We also discuss the effects and interactions between these variables as well as their impact in the treatment of vascular diseases.

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Authors and Affiliations

  1. Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  2. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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  1. Lara Lellis Navarro Minchillo Lopes
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  1. Department of Surgery, Vascular Surgery Section, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Tulio Pinho Navarro

  2. Postgraduate Program in Sciences Applied to Surgery, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

    Lara Lellis Navarro Minchillo Lopes

  3. Vascular Biology and Therapeutics Program and the Departments of Surgery and Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA

    Alan Dardik

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Lopes, L.L.N.M., Navarro, T.P., Dardik, A. (2021). Introduction to Stem Cell Therapy and Its Application in Vascular Diseases. In: Navarro, T.P., Minchillo Lopes, L.L.N., Dardik, A. (eds) Stem Cell Therapy for Vascular Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-56954-9_1

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