Skip to main content

Neurophysiology in Children and Elderlies with Migraine

  • 478 Accesses

Part of the Headache book series (HEAD)

Abstract

Neurophysiologic techniques have proved very useful in studying migraine patients. The main contribution of clinical neurophysiology regards the pathophysiological investigation of primary headaches. The primary headache phenotype is the result of the contribution of both genetic and environmental factors, the first being prevalent in childhood and the second in elderly. Seen from this light, it is surprising that neurophysiologic investigation has been far more often addressed to the young adulthood, while children and elderlies migraineurs have been rarely studied. While neurophysiologic studies in children and adolescents contributed to highlight some peculiarities that primary headaches show in this population, the elderly age appears to be fully neglected. In this chapter, some potentially interesting areas related to primary headache pathophysiology are presented. It will be underlined how the present knowledge in these areas would benefit from data collected also from childhood and elderly.

Keywords

  • Migraine
  • Tension-type headache
  • Children
  • Habituation
  • Evoked potentials
  • Brain maturation
  • Headache
  • Adolescents
  • Elderly
  • Migraine

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-030-56538-1_15
  • Chapter length: 10 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   64.99
Price excludes VAT (USA)
  • ISBN: 978-3-030-56538-1
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   84.99
Price excludes VAT (USA)
Hardcover Book
USD   119.99
Price excludes VAT (USA)
Fig. 15.1
Fig. 15.2

References

  1. Silberstein SD. Evaluation and emergency treatment of headache. Headache. 1992;32:396–407.

    CrossRef  CAS  PubMed  Google Scholar 

  2. Cohen AS, Goadsby PJ. Functional neuroimaging of primary headache disorders. Curr Pain Headache Rep. 2005;9:141–6.

    CrossRef  PubMed  Google Scholar 

  3. Colombo B, Messina R, Rocca MA, Filippi M. Imaging the migrainous brain: the present and the future. Neurol Sci. 2019;40(Suppl 1):49–54.

    CrossRef  PubMed  Google Scholar 

  4. Hobson AR, Aziz Q. Brain processing of esophageal sensation in health and disease. Gastroenterol Clin N Am. 2004;33:69–91.

    CrossRef  Google Scholar 

  5. Sharma A, Lelic D, Brock C, Paine P, Aziz Q. New technologies to investigate the brain-gut axis. World J Gastroenterol. 2009;15:182–91.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  6. Valeriani M, Le Pera D, Tonali P. Characterizing somatosensory evoked potential sources with dipole models: advantages and limitations. Muscle Nerve. 2001;24:325–39.

    CrossRef  CAS  PubMed  Google Scholar 

  7. Valeriani M. Is there a role of clinical neurophysiology in primary headache? Clin Neurophysiol. 2005;116:2717–8.

    CrossRef  PubMed  Google Scholar 

  8. De Tommaso M. Central nervous system excitability in migraine: who is right? Pain. 2005;118:137–4.

    CrossRef  Google Scholar 

  9. De Tommaso M, Ambrosini A, Brighina F, et al. Altered processing of sensory stimuli in patients with migraine. Nat Rev Neurol. 2014;10:144–55.

    CrossRef  PubMed  Google Scholar 

  10. Brinciotti M, Guidetti V, Matricardi M, Cortesi F. Responsiveness of the visual system in childhood migraine studied by means of VEPs. Cephalalgia. 1986;6:183–5.

    CrossRef  CAS  PubMed  Google Scholar 

  11. Aloisi P, Marrelli A, Porto C, Tozzi E, Cerone G. Visual evoked potentials and serum magnesium levels in juvenile migraine patients. Headache. 1997;37:383–5.

    CrossRef  CAS  PubMed  Google Scholar 

  12. Lahat E, Nadir E, Barr J, Eshel G, Aladjem M, Bistritze T. Visual evoked potentials: a diagnostic test for migraine headache in children. Dev Med Child Neurol. 1997;39:85–7.

    CrossRef  CAS  PubMed  Google Scholar 

  13. Unay B, Ulas UH, Karaoglu B, Eroglu E, Akin R, Gokcay E. Visual and brainstem auditory evoked potentials in children with headache. Pediatr Int. 2008;50:620–3.

    CrossRef  PubMed  Google Scholar 

  14. Lehtonen JB. Visual evoked cortical potentials for single flashes and flickering light in migraine. Headache. 1974;14:1–12.

    CrossRef  CAS  PubMed  Google Scholar 

  15. Connolly JF, Gawel M, Rose FC. Migraine patients exhibit abnormalities in the visual evoked potential. J Neurol Neurosurg Psychiatry. 1982;45:464–7.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  16. Ambrosini A, de Noordhout AM, Sándor PS, Schoenen J. Electrophysiological studies in migraine: a comprehensive review of their interest and limitations. Cephalalgia. 2003;1(Suppl):13–31.

    CrossRef  Google Scholar 

  17. Coppola G, Pierelli F, Schoenen J. Habituation and migraine. Neurobiol Learn Mem. 2009;92:249–59.

    CrossRef  PubMed  Google Scholar 

  18. Oelkers-Ax R, Parzer P, Resch F, Weisbrod M. Maturation of early visual processing investigated by a pattern-reversal habituation paradigm is altered in migraine. Cephalalgia. 2005;25:280–9.

    CrossRef  CAS  PubMed  Google Scholar 

  19. Valeriani M, Rinalduzzi S, Vigevano F. Multilevel somatosensory system disinhibition in children with migraine. Pain. 2005;118:137–44.

    CrossRef  PubMed  Google Scholar 

  20. Vollono C, Ferraro D, Miliucci R, Vigevano F, Valeriani M. The abnormal recovery cycle of somatosensory evoked potential components in children with migraine can be reversed by topiramate. Cephalalgia. 2010;30:17–26.

    CrossRef  CAS  PubMed  Google Scholar 

  21. Evers S, Bauer B, Grotemeyer KH, Kurlemann G, Husstedt IW. Event-related potentials (P300) in primary headache in childhood and adolescence. J Child Neurol. 1998;13:322–6.

    CrossRef  CAS  PubMed  Google Scholar 

  22. Zohsel K, Hohmeister J, Flor H, Hermann C. Altered pain processing in children with migraine: an evoked potential study. Eur J Pain. 2008;12:1090–101.

    CrossRef  PubMed  Google Scholar 

  23. Valeriani M, Galli F, Tarantino S, et al. Correlation between abnormal brain excitability and emotional symptomatology in paediatric migraine. Cephalalgia. 2009;29:204–13.

    CrossRef  CAS  PubMed  Google Scholar 

  24. Cady R, Schreiber C, Farmer K, Sheftell F. Primary headaches: a convergence hypothesis. Headache. 2002;42:204–16.

    CrossRef  PubMed  Google Scholar 

  25. Evers S, Bauer B, Suhr B, Husstedt IW, Grotemeyer KH. Cognitive processing in primary headache: a study on event-related potentials. Neurology. 1997;48:108–13.

    CrossRef  CAS  PubMed  Google Scholar 

  26. Maertens de Noordhout A, Timsit-Berthier M, Timsit M, Schoenen J. Contingent negative variation in headache. Ann Neurol. 1986;19:78–80.

    CrossRef  CAS  PubMed  Google Scholar 

  27. Iacovelli E, Tarantino S, De Ranieri C, et al. Psychophysiological mechanisms underlying spatial attention in children with primary headache. Brain and Development. 2012;34:640–7.

    CrossRef  PubMed  Google Scholar 

  28. Bender S, Weisbrod M, Resch F, Oelkers-Ax R. Stereotyped topography of different elevated contingent negative variation components in children with migraine without aura points towards a subcortical dysfunction. Pain. 2007;127:221–33.

    CrossRef  PubMed  Google Scholar 

  29. Battistella PA, Fiumana E, Binelli M, et al. Primary headaches in preschool age children: clinical study and follow-up in 163 patients. Cephalalgia. 2006;26:162–71.

    CrossRef  CAS  PubMed  Google Scholar 

  30. Kienbacher C, Wöber C, Zesch HE, et al. Clinical features, classification and prognosis of migraine and tension-type headache in children and adolescents: a long-term follow-up study. Cephalalgia. 2006;26:820–30.

    CrossRef  CAS  PubMed  Google Scholar 

  31. Kropp P, Siniatchkin M, Stephani U, Gerber WD. Migraine – evidence for a disturbance of cerebral maturation in man? Neurosci Lett. 1999;276:181–4.

    CrossRef  CAS  PubMed  Google Scholar 

  32. Oelkers-Ax R, Bender S, Just U, et al. Pattern-reversal visual-evoked potentials in children with migraine and other primary headache: evidence for maturation disorder? Pain. 2004;108:267–75.

    CrossRef  PubMed  Google Scholar 

  33. Garcia-Larrea L, Lukaszewicz AC, Mauguière F. Somatosensory responses during selective spatial attention: the N120- to-N140 transition. Psychophysiology. 1995;32:526–37.

    CrossRef  CAS  PubMed  Google Scholar 

  34. Buodo G, Sarlo M, Battistella PA, Naccarella C, Palomba D. Event-related potentials to emotional stimuli in migrainous children. J Child Neurol. 2011;26:1508–15.

    CrossRef  PubMed  Google Scholar 

  35. WHO. Elderly population. Health situation and trend assessment 2019 (23-06-2019). Geneva: WHO; 2019.

    Google Scholar 

  36. United Nations. World population prospects 2019: highlights 2019 (23-06-2019). New York, NY: UN; 2019.

    CrossRef  Google Scholar 

  37. WHO. Global health and aging 2019 (23-06-2019). Geneva: WHO; 2019.

    Google Scholar 

  38. Pascual J, Berciano J. Experience in the diagnosis of headaches that start in elderly people. J Neurol Neurosurg Psychiatry. 1994;57:1255–7.

    CrossRef  CAS  PubMed  PubMed Central  Google Scholar 

  39. Ruiz M, Pedraza MI, De La Cruz C, et al. Headache in the elderly: characteristics in a series of 262 patients. Neurologia. 2014;29:321–6.

    CrossRef  CAS  PubMed  Google Scholar 

  40. Hale WE, May FE, Marks RG, Moore MT, Stewart RB. Headache in the elderly: an evaluation of risk factors. Headache. 1987;27:272–6.

    CrossRef  CAS  PubMed  Google Scholar 

  41. Cook NR, Evans DA, Funkenstein HH, et al. Correlates of headache in a population-based cohort of elderly. Arch Neurol. 1989;46:1338–44.

    CrossRef  CAS  PubMed  Google Scholar 

  42. Semenov IA. Headache in the elderly. Dis Mon. 2015;61:249–50.

    CrossRef  PubMed  Google Scholar 

  43. Evers S, Goadsby PJ. Hypnic headache: clinical features, pathophysiology, and treatment. Neurology. 2003;60:905–9.

    CrossRef  PubMed  Google Scholar 

  44. Delaruelle Z, Ivanova TA, Khan S, et al. Male and female sex hormones in primary headaches. J Headache Pain. 2018;19:117.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  45. Wijeratne T, Tang HM, Crewther D, Crewther S. Prevalence of migraine in the elderly: a narrated review. Neuroepidemiology. 2019;52:104–10.

    CrossRef  PubMed  Google Scholar 

  46. Martins KM, Bordini CA, Bigal ME, Speciali JG. Migraine in the elderly: a comparison with migraine in young adults. Headache. 2006;46:312–6.

    CrossRef  PubMed  Google Scholar 

  47. De Rijk P, Resseguier N, Donnet A. Headache characteristics and clinical features of elderly migraine patients. Headache. 2018;58:525–33.

    CrossRef  PubMed  Google Scholar 

  48. Uthaikhup S, Sterling M, Jull G. Widespread sensory hypersensitivity is not a feature of chronic headache in elders. Clin J Pain. 2009;25:699–704.

    CrossRef  PubMed  Google Scholar 

  49. Ripa P, Ornello R, Degan D, et al. Migraine in menopausal women: a systematic review. Int J Women’s Health. 2015;7:773–82.

    Google Scholar 

  50. Song TJ, Kim YJ, Kim BK, et al. Characteristics of elderly-onset (>/=65 years). Headache diagnosed using the international classification of headache disorders, third edition Beta version. J Clin Neurol. 2016;12:419–25.

    CrossRef  PubMed  PubMed Central  Google Scholar 

  51. Mattsson P. Serum levels of androgens and migraine in postmenopausal women. Clin Sci (Lond). 2002;103:487–91.

    CrossRef  CAS  Google Scholar 

  52. Lai TH, Protsenko E, Cheng YC, Loggia ML, Coppola G, Chen WT. Neural plasticity in common forms of chronic headaches. Neural Plast. 2015;2015(205985):1.

    CrossRef  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Massimiliano Valeriani .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Verify currency and authenticity via CrossMark

Cite this chapter

Valeriani, M., Gazerani, P. (2021). Neurophysiology in Children and Elderlies with Migraine. In: Coppola, G., Chen, WT. (eds) Neurophysiology of the Migraine Brain. Headache. Springer, Cham. https://doi.org/10.1007/978-3-030-56538-1_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-56538-1_15

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-56537-4

  • Online ISBN: 978-3-030-56538-1

  • eBook Packages: MedicineMedicine (R0)