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Computational Modeling of the Coagulation Response During Trauma

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Complex Systems and Computational Biology Approaches to Acute Inflammation

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Abstract

Coagulation and platelet aggregation are the primary mechanisms for maintaining hemostasis upon traumatic injury. However, prolonged bleeding may lead to trauma-induced coagulopathy (TIC) or the apparent phenomenon of blood coagulation is impaired upon prolonged blood loss. This has been studied extensively via computational modeling, where the overall goal is to quantify metabolic responses, predict responses to physiological perturbations, and develop “on-the-fly” patient-specific strategies. Models of trauma patient evolution and clot growth rates have been developed to better understand the evolution of TIC in a trauma patient. Mechanistic and statistical models have been informed via experiment, whereby the trauma patient blood is acquired at marked time intervals after injury to better stratify the patient bleeding risks, prioritize biomarkers, and identify new opportunities for safer treatment options.

Evan J. Tsiklidis and Christopher C. Verni are co-first authors.

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Abbreviations

ADP:

Adenosine diphosphate

DIC:

Disseminated intravascular coagulation

FEM:

Finite element method

LB:

Lattice Boltzmann

LKMC:

Lattice kinetic Monte Carlo

NN:

Neural network

ODE:

Ordinary differential equation

PAS:

Pairwise agonist scanning

PAS-FC:

Pairwise agonist scanning-flow cytometry

PBRC:

Packed red blood cells

PDE:

Partial differential equation

PRP:

Platelet-rich plasma

TAT:

Thrombin-antithrombin

TBI:

Traumatic brain injury

TEG:

Thromboelastography

TF:

Inflammatory tissue factor

TIC:

Trauma-induced coagulopathy

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Author information

Authors and Affiliations

  1. Institute for Medicine and Engineering, University of Pennsylvania, Vagelos Research Laboratory, Philadelphia, PA, USA

    Evan J. Tsiklidis, Christopher C. Verni, Talid Sinno & Scott L. Diamond

Authors
  1. Evan J. Tsiklidis
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  2. Christopher C. Verni
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  3. Talid Sinno
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  4. Scott L. Diamond
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Corresponding author

Correspondence to Scott L. Diamond .

Editor information

Editors and Affiliations

  1. Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA

    Yoram Vodovotz

  2. Department of Surgery, University of Vermont, Burlington, VT, USA

    Gary An

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Tsiklidis, E.J., Verni, C.C., Sinno, T., Diamond, S.L. (2021). Computational Modeling of the Coagulation Response During Trauma. In: Vodovotz, Y., An, G. (eds) Complex Systems and Computational Biology Approaches to Acute Inflammation. Springer, Cham. https://doi.org/10.1007/978-3-030-56510-7_9

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