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Molecular Diagnostics: Innovative Technologies for Clinical and Translational Research

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Practical Medical Oncology Textbook

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Abstract

In recent years, cancer patients’ treatment has profoundly changed due to a better comprehension of the biological processes underlying tumor development and progression. Several tumors are defined as “oncogene addicted” meaning that they are strictly dependent on oncogene activation for their own survival. This discovery has indeed led the way to the development of target therapies that are able to specifically kill cancer cells sparing normal cells from toxicity. For these reasons, nowadays, treatment decision is strictly dependent on the molecular characterization of the tumor that can be achieved through different technologies. Within this chapter, we will discuss the main technologies that are used in clinical practice for molecular characterization of tumor samples.

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Author information

Authors and Affiliations

  1. Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy

    Marta Castiglia

  2. Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy

    Alessandro Perez

  3. Department of Public Health, University of Naples Federico II, Naples, Italy

    Francesco Pepe & Umberto Malapelle

Authors
  1. Marta Castiglia
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  2. Francesco Pepe
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  3. Alessandro Perez
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  4. Umberto Malapelle
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Editor information

Editors and Affiliations

  1. Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy

    Antonio Russo

  2. Oncology Department, University of Antwerp, Edegem, Belgium

    Marc Peeters

  3. Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy

    Lorena Incorvaia

  4. Center for Thoracic Oncology, Tisch Cancer Institute, Mount Sinai System & Icahn School of Medicine, Mount Sinai, NY, USA

    Christian Rolfo

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Castiglia, M., Pepe, F., Perez, A., Malapelle, U. (2021). Molecular Diagnostics: Innovative Technologies for Clinical and Translational Research. In: Russo, A., Peeters, M., Incorvaia, L., Rolfo, C. (eds) Practical Medical Oncology Textbook. UNIPA Springer Series. Springer, Cham. https://doi.org/10.1007/978-3-030-56051-5_8

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  • DOI: https://doi.org/10.1007/978-3-030-56051-5_8

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-030-56051-5

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