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Head and Neck Cancers

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References

  1. Gatta G, van der Zwan JM, Casali PG, et al. Rare cancers are not so rare: the rare cancer burden in Europe. Eur J Cancer. 2011;47(17):2493–511. https://doi.org/10.1016/j.ejca.2011.08.008.

    Article  PubMed  Google Scholar 

  2. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86. https://doi.org/10.1002/ijc.29210.

    Article  CAS  PubMed  Google Scholar 

  3. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30. https://doi.org/10.3322/caac.21442.

    Article  PubMed  Google Scholar 

  4. Poo DCC. Explicit representation of business policies. In: Proceedings - 1998 Asia Pacific software engineering conference, APSEC 1998. Vol 1998-Decem; 1998. p. 136–43. https://doi.org/10.1200/JCO.2013.50.3870.

    Chapter  Google Scholar 

  5. Chaturvedi AK, D’Souza G, Gillison ML, Katki HA. Burden of HPV-positive oropharynx cancers among ever and never smokers in the U.S. population. Oral Oncol. 2016;60 https://doi.org/10.1016/j.oraloncology.2016.06.006.

  6. Gatta G, Botta L, Sánchez MJ, et al. Prognoses and improvement for head and neck cancers diagnosed in Europe in early 2000s: the EUROCARE-5 population-based study. Eur J Cancer. 2015;51(15):2130–43. https://doi.org/10.1016/j.ejca.2015.07.043.

    Article  PubMed  Google Scholar 

  7. Talamini R, Bosetti C, La Vecchia C, et al. Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study. Cancer Causes Control. 2002;13(10):957–64. http://www.ncbi.nlm.nih.gov/pubmed/12588092. Accessed 5 June 2018.

    Article  CAS  PubMed  Google Scholar 

  8. Boakye EA, Buchanan P, Hinyard L, Osazuwa-Peters N, Schootman M, Piccirillo JF. Incidence and risk of second primary malignant neoplasm after a first head and neck squamous cell carcinoma. JAMA Otolaryngol - Head Neck Surg. 2018;144(8):727–37. https://doi.org/10.1001/jamaoto.2018.0993.

    Article  Google Scholar 

  9. Gillison ML, Koch WM, Capone RB, et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst. 2000;92(9):709–20. http://www.ncbi.nlm.nih.gov/pubmed/10793107

    Article  CAS  PubMed  Google Scholar 

  10. Gillison MLMLML, Restighini C. Anticipation of the impact of human papillomavirus on clinical decision making for the head and neck cancer patient. Hematol Oncol Clin North Am. 2015;29:1045–60. https://doi.org/10.1016/j.hoc.2015.08.003.

    Article  PubMed  Google Scholar 

  11. El-Mofty SK, Patil S. Human papillomavirus (HPV)-related oropharyngeal nonkeratinizing squamous cell carcinoma: characterization of a distinct phenotype. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2006;101(3):339–45. https://doi.org/10.1016/j.tripleo.2005.08.001.

    Article  Google Scholar 

  12. Huang SH, Perez-Ordonez B, Liu FF, et al. Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy. Int J Radiat Oncol Biol Phys. 2012;82(1):276–83. https://doi.org/10.1016/j.ijrobp.2010.08.031.

    Article  PubMed  Google Scholar 

  13. Guha N, Warnakulasuriya S, Vlaanderen J, Straif K. Betel quid chewing and the risk of oral and oropharyngeal cancers: a meta-analysis with implications for cancer control. Int J Cancer. 2014;135(6):1433–43. https://doi.org/10.1002/ijc.28643.

    Article  CAS  PubMed  Google Scholar 

  14. Chuang S-C, Jenab M, Heck JE, et al. Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium. Cancer Causes Control. 2012;23(1):69–88. https://doi.org/10.1007/s10552-011-9857-x.

    Article  PubMed  Google Scholar 

  15. Huang SH, O’Sullivan B. Overview of the 8th edition TNM classification for head and neck cancer. Curr Treat Options in Oncol. 2017;18(7):40. https://doi.org/10.1007/s11864-017-0484-y.

    Article  Google Scholar 

  16. Michaels L, Hellquist HB. Malignant neoplasms of surface epithelium. In: Ear, nose and throat histopathology. London: Springer London; 2001. p. 186–91. https://doi.org/10.1007/978-1-4471-0235-9_16.

    Chapter  Google Scholar 

  17. Mascharak S, Baird BJ, Holsinger FC. Detecting oropharyngeal carcinoma using multispectral, narrow-band imaging and machine learning. Laryngoscope. 2018; https://doi.org/10.1002/lary.27159.

  18. Piazza C, Cocco D, Del Bon F, et al. Narrow band imaging and high definition television in evaluation of oral and oropharyngeal squamous cell cancer: a prospective study. Oral Oncol. 2010;46(4):307–10. https://doi.org/10.1016/j.oraloncology.2010.01.020.

    Article  CAS  PubMed  Google Scholar 

  19. Michaels L, Hellquist HB. Normal anatomy and histology. In: Ear, nose and throat histopathology. London: Springer London; 2001. p. 303–17. https://doi.org/10.1007/978-1-4471-0235-9_28.

    Chapter  Google Scholar 

  20. Iocca O, Sollecito TP, Alawi F, et al. Potentially malignant disorders of the oral cavity and oral dysplasia: a systematic review and meta-analysis of malignant transformation rate by subtype. Head Neck. 2019; https://doi.org/10.1002/hed.26006.

  21. Villa A, Villa C, Abati S. Oral cancer and oral erythroplakia: an update and implication for clinicians. Aust Dent J. 2011;56(3):253–6. https://doi.org/10.1111/j.1834-7819.2011.01337.x.

    Article  CAS  PubMed  Google Scholar 

  22. Yardimci G. Precancerous lesions of oral mucosa. World J Clin Cases. 2014;2(12):866. https://doi.org/10.12998/wjcc.v2.i12.866.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Mello FW, Miguel AFP, Dutra KL, et al. Prevalence of oral potentially malignant disorders: a systematic review and meta-analysis. J Oral Pathol Med. 2018; https://doi.org/10.1111/jop.12726.

  24. Fizazi K, Greco FA, Pavlidis N, et al. Cancers of unknown primary site: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26(suppl 5):v133–8. https://doi.org/10.1093/annonc/mdv305.

    Article  PubMed  Google Scholar 

  25. Fu TS, Foreman A, Goldstein DP, de Almeida JR. The role of transoral robotic surgery, transoral laser microsurgery, and lingual tonsillectomy in the identification of head and neck squamous cell carcinoma of unknown primary origin: a systematic review. J Otolaryngol Head Neck Surg. 2016;45(1):28. https://doi.org/10.1186/s40463-016-0142-6.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Brocklehurst P, Kujan O, O’Malley LA, Ogden G, Shepherd S, Glenny A-M. Screening programmes for the early detection and prevention of oral cancer. Cochrane Database Syst Rev. 2013;11:CD004150. https://doi.org/10.1002/14651858.CD004150.pub4.

    Article  Google Scholar 

  27. Adel K El-Naggar, John KC Chan, Jennifer R Grandis, Takashi Takata PJS. The 4th edition of the World Health Organization classification of head and neck tumours.; 2017.

    Google Scholar 

  28. Lewis-Jones H, Colley S, Gibson D. Imaging in head and neck cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016;130(S2):S28–31. https://doi.org/10.1017/S0022215116000396.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Tshering Vogel DW, Thoeny HC. Cross-sectional imaging in cancers of the head and neck: how we review and report. Cancer Imaging. 2016;16(1):20. https://doi.org/10.1186/s40644-016-0075-3.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Abraham J. Imaging for head and neck cancer. Surg Oncol Clin N Am. 2015;24(3):455–71. https://doi.org/10.1016/j.soc.2015.03.012.

    Article  PubMed  Google Scholar 

  31. Yamazaki Y, Saitoh M, Notani K, et al. Assessment of cervical lymph node metastases using FDG-PET in patients with head and neck cancer. Ann Nucl Med. 2008;22(3):177–84. https://doi.org/10.1007/s12149-007-0097-9.

    Article  PubMed  Google Scholar 

  32. Lydiatt WM, Patel SG, O’Sullivan B, et al. Head and neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(2):122–37. https://doi.org/10.3322/caac.21389.

    Article  PubMed  Google Scholar 

  33. Robbins KT, Shaha AR, Medina JE, et al. Consensus statement on the classification and terminology of neck dissection. Arch Otolaryngol Neck Surg. 2008;134(5):536. https://doi.org/10.1001/archotol.134.5.536.

    Article  Google Scholar 

  34. Licitra L, Keilholz U, Tahara M, et al. Evaluation of the benefit and use of multidisciplinary teams in the treatment of head and neck cancer. Oral Oncol. 2016;59:73–9. https://doi.org/10.1016/j.oraloncology.2016.06.002.

    Article  PubMed  Google Scholar 

  35. Vermorken JB. Multidisciplinary decision making and head and neck tumor boards. In: Critical issues in head and neck oncology. Key concepts from the fifth THNO meeting; 2017. p. 99–108.

    Chapter  Google Scholar 

  36. Gorphe P. A contemporary review of evidence for Transoral robotic surgery in laryngeal cancer. Front Oncol. 2018;8:121. https://doi.org/10.3389/fonc.2018.00121.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Castelnuovo P, Battaglia P, Turri-Zanoni M, et al. Endoscopic endonasal surgery for malignancies of the anterior cranial base. World Neurosurg. 2014;82(6):S22–31. https://doi.org/10.1016/j.wneu.2014.07.021.

    Article  PubMed  Google Scholar 

  38. Sakuraba M, Miyamoto S, Kimata Y, et al. Recent advances in reconstructive surgery: head and neck reconstruction. Int J Clin Oncol. 2013;18(4):561–5. https://doi.org/10.1007/s10147-012-0513-6.

    Article  PubMed  Google Scholar 

  39. Lee N, Puri DR, Blanco AI, Chao KSC. Intensity-modulated radiation therapy in head and neck cancers: an update. Head Neck. 2007;29(4):387–400. https://doi.org/10.1002/hed.20332.

    Article  PubMed  Google Scholar 

  40. Bernier J, Cooper JS, Pajak TF, et al. Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501). Head Neck. 2005;27(10):843–50. https://doi.org/10.1002/hed.20279.

    Article  PubMed  Google Scholar 

  41. Hitt R, Grau JJ, López-Pousa A, et al. A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer. Ann Oncol. 2014;25(1):216–25. https://doi.org/10.1093/annonc/mdt461.

    Article  CAS  PubMed  Google Scholar 

  42. Haddad R, O’Neill A, Rabinowits G, et al. Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial. Lancet Oncol. 2013;14(3):257–64. https://doi.org/10.1016/S1470-2045(13)70011-1.

    Article  CAS  PubMed  Google Scholar 

  43. Zhong L, Zhang C, Ren G, et al. Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma. J Clin Oncol. 2013;31(6):744–51. https://doi.org/10.1200/JCO.2012.43.8820.

    Article  CAS  PubMed  Google Scholar 

  44. Lefebvre JL, Pointreau Y, Rolland F, et al. Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study. J Clin Oncol. 2013;31(7):853–9. https://doi.org/10.1200/JCO.2012.42.3988.

    Article  CAS  PubMed  Google Scholar 

  45. Pignon J-P, le Maître A, Maillard E, Bourhis J, MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol. 2009;92(1):4–14. https://doi.org/10.1016/j.radonc.2009.04.014.

    Article  PubMed  Google Scholar 

  46. Noronha V, Joshi A, Patil VM, et al. Once-a-week versus once-every-3-weeks cisplatin chemoradiation for locally advanced head and neck cancer: a phase III randomized noninferiority trial. J Clin Oncol. 2018;36(11):1064–72. https://doi.org/10.1200/JCO.2017.74.9457.

    Article  CAS  PubMed  Google Scholar 

  47. Strojan P, Vermorken JB, Beitler JJ, et al. Cumulative cisplatin dose in concurrent chemoradiotherapy for head and neck cancer: a systematic review. Eisele DW, ed Head Neck. 2016;38(S1):E2151–8. https://doi.org/10.1002/hed.24026.

    Article  Google Scholar 

  48. Szturz P, Cristina V, Gómez RGH, Bourhis J, Simon C, Vermorken JB. Cisplatin eligibility issues and alternative regimens in locoregionally advanced head and neck cancer: recommendations for clinical practice. Front Oncol. 2019; https://doi.org/10.3389/fonc.2019.00464.

  49. Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus Cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567–78. https://doi.org/10.1056/NEJMoa053422.

    Article  CAS  PubMed  Google Scholar 

  50. Ang KK, Zhang Q, Rosenthal DI, et al. Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522. J Clin Oncol. 2014;32(27):2940–50. https://doi.org/10.1200/JCO.2013.53.5633.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Chen AM, Chen LM, Vaughan A, et al. Tobacco smoking during radiation therapy for head-and-neck cancer is associated with unfavorable outcome. Int J Radiat Oncol. 2011;79(2):414–9. https://doi.org/10.1016/j.ijrobp.2009.10.050.

    Article  Google Scholar 

  52. Devi S, Singh N. Dental care during and after radiotherapy in head and neck cancer. Natl J Maxillofac Surg. 2014;5(2):117. https://doi.org/10.4103/0975-5950.154812.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Anderson NJ, Jackson JE, Smith JG, et al. Pretreatment risk stratification of feeding tube use in patients treated with intensity-modulated radiotherapy for head and neck cancer. Head Neck. 2018; https://doi.org/10.1002/hed.25316.

  54. Brown T, Banks M, Hughes BGM, Lin C, Kenny LM, Bauer JD. Impact of early prophylactic feeding on long term tube dependency outcomes in patients with head and neck cancer. Oral Oncol. 2017;72:17–25. https://doi.org/10.1016/j.oraloncology.2017.06.025.

    Article  PubMed  Google Scholar 

  55. Lalla RV, Bowen J, Barasch A, et al. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014;120(10):1453–61. https://doi.org/10.1002/cncr.28592.

    Article  PubMed  Google Scholar 

  56. Wong RKS, Bensadoun R-J, Boers-Doets CB, et al. Clinical practice guidelines for the prevention and treatment of acute and late radiation reactions from the MASCC Skin Toxicity Study Group. Support Care Cancer. 2013;21(10):2933–48. https://doi.org/10.1007/s00520-013-1896-2.

    Article  PubMed  Google Scholar 

  57. Ferreira EB, Vasques CI, Gadia R, et al. Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review. Support Care Cancer. 2017;25(3):1001–11. https://doi.org/10.1007/s00520-016-3521-7.

    Article  PubMed  Google Scholar 

  58. Hovan AJ, Williams PM, Stevenson-Moore P, et al. A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer. 2010;18(8):1081–7. https://doi.org/10.1007/s00520-010-0902-1.

    Article  PubMed  Google Scholar 

  59. Crona DJ, Faso A, Nishijima TF, McGraw KA, Galsky MD, Milowsky MI. A systematic review of strategies to prevent cisplatin-induced nephrotoxicity. Oncologist. 2017;22(5):609–19. https://doi.org/10.1634/theoncologist.2016-0319.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Calabrese L, Bruschini R, Giugliano G, et al. Compartmental tongue surgery: long term oncologic results in the treatment of tongue cancer. Oral Oncol. 2011;47(3):174–9. https://doi.org/10.1016/j.oraloncology.2010.12.006.

    Article  PubMed  Google Scholar 

  61. Forastiere AA, Zhang Q, Weber RS, et al. Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol. 2013;31(7):845–52. https://doi.org/10.1200/JCO.2012.43.6097.

    Article  CAS  PubMed  Google Scholar 

  62. Pointreau Y, Garaud P, Chapet S, et al. Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation. JNCI J Natl Cancer Inst. 2009;101(7):498–506. https://doi.org/10.1093/jnci/djp007.

    Article  CAS  PubMed  Google Scholar 

  63. Lorenz KJ. Rehabilitation after total laryngectomy-A tribute to the pioneers of voice restoration in the last two centuries. Front Med. 2017; https://doi.org/10.3389/fmed.2017.00081.

  64. Lefebvre J-L, Andry G, Chevalier D, et al. Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma: 10-year results of EORTC trial 24891. Ann Oncol. 2012;23(10):2708–14. https://doi.org/10.1093/annonc/mds065.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 2008;359(11):1116–27. https://doi.org/10.1056/NEJMoa0802656.

    Article  CAS  PubMed  Google Scholar 

  66. Bossi P, Miceli R, Locati LD, et al. A randomized, phase 2 study of cetuximab plus cisplatin with or without paclitaxel for the first-line treatment of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck. Ann Oncol. 2017;28(11):2820–6. https://doi.org/10.1093/annonc/mdx439.

    Article  CAS  PubMed  Google Scholar 

  67. Rischin P final analysis of the phase 3 K-048 trial of pembrolizumab (pembro) as first-line therapy for recurrent/metastatic head and neck squamous cell carcinoma (R/M HD), Harrington KJ, Greil R, et al. Protocol-specified final analysis of the phase 3 KEYNOTE-048 trial of pembrolizumab (pembro) as first-line therapy for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). J Clin Oncol. 2019;37(15_suppl):6000. https://doi.org/10.1200/JCO.2019.37.15_suppl.6000.

    Article  Google Scholar 

  68. Cavalieri S, Rivoltini L, Bergamini C, Locati LD, Licitra L, Bossi P. Immuno-oncology in head and neck squamous cell cancers: news from clinical trials, emerging predictive factors and unmet needs. Cancer Treat Rev. 2018;65:78–86. https://doi.org/10.1016/j.ctrv.2018.03.003.

    Article  PubMed  Google Scholar 

  69. Ferris RL, Blumenschein G, Fayette J, et al. Nivolumab for recurrent squamous-cell carcinoma of the head and neck. N Engl J Med. 2016;375(19):1856–67. https://doi.org/10.1056/NEJMoa1602252.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Cohen EEW, Soulières D, Le Tourneau C, et al. Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study. Lancet. 2019;393(10167):156–67. https://doi.org/10.1016/S0140-6736(18)31999-8.

    Article  CAS  PubMed  Google Scholar 

  71. Siano M, Infante G, Resteghini C, et al. Outcome of recurrent and metastatic head and neck squamous cell cancer patients after first line platinum and cetuximab therapy. Oral Oncol. 2017;69:33–7. https://doi.org/10.1016/j.oraloncology.2017.04.002.

    Article  CAS  PubMed  Google Scholar 

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Resteghini, C. et al. (2021). Head and Neck Cancers. In: Russo, A., Peeters, M., Incorvaia, L., Rolfo, C. (eds) Practical Medical Oncology Textbook. UNIPA Springer Series. Springer, Cham. https://doi.org/10.1007/978-3-030-56051-5_43

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