Skip to main content

Psychedelic Medicines: A Paradigm Shift from Pharmacological Substitution Towards Transformation-Based Psychiatry

Abstract

While psychoactive drugs such as ketamine and psilocybin have been researched extensively in the past decades, scientific interest in ayahuasca has just started to grow, due to its potential therapeutic benefits. Beyond its traditional indigenous and mestizo use in the Amazon, ayahuasca is currently spreading all over the world as an alternative plant medicine in various ritualistic contexts. This rapid dissemination coincides with the observational evidence that ayahuasca facilitates transformational processes with beneficial health outcomes. However, more empirical research is needed to move beyond anecdotal evidence and further verify therapeutic efficacy and biomechanisms of ayahuasca under controlled conditions. The objective of this chapter is to outline future possibilities of ayahuasca-assisted therapies based on the biomedical literature on psychedelics and other contexts in which ayahuasca is used to support health and wellbeing. First, psychedelic medicines will be contrasted with standard psychopharmaceuticals as a novel treatment option that necessitates a paradigm shift from substitution- to transformation-based therapy. Second, various adaptogenic effects of ayahuasca will be reviewed, including effects on body, brain, and mental functioning. Third, a novel transformational psychotherapy framework will be introduced that outlines how ayahuasca could be used to support sustainable transformation. Finally, future research directions of developing pharmahuasca applications in clinical settings will be contrasted with traditional and indigenous contexts of ayahuasca use, highlighting the challenges of intercultural knowledge transfer.

Keywords

  • Biomechanisms
  • Adaptogenic effects
  • Mindfulness
  • Transformational psychotherapy
  • Pharmahuasca

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-030-55688-4_3
  • Chapter length: 19 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   129.00
Price excludes VAT (USA)
  • ISBN: 978-3-030-55688-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   169.99
Price excludes VAT (USA)
Hardcover Book
USD   169.99
Price excludes VAT (USA)
Fig. 3.1

References

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Milan Scheidegger .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Verify currency and authenticity via CrossMark

Cite this chapter

Scheidegger, M. (2021). Psychedelic Medicines: A Paradigm Shift from Pharmacological Substitution Towards Transformation-Based Psychiatry. In: Labate, B.C., Cavnar, C. (eds) Ayahuasca Healing and Science. Springer, Cham. https://doi.org/10.1007/978-3-030-55688-4_3

Download citation