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Na+-K+-2Cl− Cotransporter

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Studies of Epithelial Transporters and Ion Channels

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

The conceptual breakthrough that the energy of the Na+ gradient generated by the Na+/K+ ATPase (pump) could be used as the driving force for another membrane transport protein has led to the functional and molecular identification of multiple secondary active transporters. We have organized this chapter to address the expression, function, regulation, and evolutionary importance of the two isoforms of the electroneutral sodium–potassium–chloride cotransporter (NKCC). The combination of basolateral expression of the sodium–potassium pump and NKCC1 in various non-renal epithelial results in salt and water secretion, whereas basolateral expression of the pump with an apical expression of NKCC2 in the thick ascending limb of Henle of the kidney nephron results in salt and water reabsorption. NKCCs are regulated by phosphorylation of specific serine/threonine residues in their cytosolic amino-terminal domains, and the evolutionary conservation of these cotransporters from protists to humans confirms their vital role in cellular and whole-organism physiology.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Vanderbilt University School of Medicine, Nashville, TN, USA

    Eric Delpire

  2. Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA

    Kenneth B. Gagnon

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  1. Eric Delpire
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  2. Kenneth B. Gagnon
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Correspondence to Eric Delpire .

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Editors and Affiliations

  1. Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, Otago, New Zealand

    Kirk L. Hamilton

  2. Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA, USA

    Daniel C. Devor

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Delpire, E., Gagnon, K.B. (2020). Na+-K+-2Cl− Cotransporter. In: Hamilton, K.L., Devor, D.C. (eds) Studies of Epithelial Transporters and Ion Channels. Physiology in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-55454-5_2

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