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Pancreas and Islet Transplantation: Pancreas and Islet Transplantation in Diabetes Mellitus

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Transplantation Surgery

Part of the book series: Springer Specialist Surgery Series ((SPECIALIST))

Abstract

Islet and pancreas transplantation are established and successful treatments for selected people with advanced diabetes. Whole organ pancreas transplant or islet transplant may be offered to patients with brittle diabetes at high risk, suffering hypoglycaemic unawareness. For people with advanced diabetes and associated nephropathy, combined pancreas kidney transplantation offers insulin-independence and improved quantity and quality of life. For optimal outcomes, donor selection is key and thus often approached highly conservatively. This is to avoid the risk of complications, particularly graft pancreatitis which may result in graft loss. Pancreas graft rejection is poorly defined and as such monitoring and surveillance of pancreas recipients remains a challenge. This chapter provides an overview of some of the key issues in pancreas transplantation.

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Author information

Authors and Affiliations

  1. Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK

    Paul Johnson & Peter J. Friend

  2. Oxford University Hospitals NHS Trust, Oxford, UK

    Edward Sharples & Sanjay Sinha

Authors
  1. Paul Johnson
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  2. Edward Sharples
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  3. Sanjay Sinha
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  4. Peter J. Friend
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Corresponding author

Correspondence to Peter J. Friend .

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Editors and Affiliations

  1. Imperial College London, London, UK

    Nadey Hakim

  2. BaÅŸkent University, Ankara, Turkey

    Mehmet Haberal

  3. University of Virginia Medical Center, Charlottesville, VA, USA

    Daniel Maluf

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Johnson, P., Sharples, E., Sinha, S., Friend, P.J. (2021). Pancreas and Islet Transplantation: Pancreas and Islet Transplantation in Diabetes Mellitus. In: Hakim, N., Haberal, M., Maluf, D. (eds) Transplantation Surgery. Springer Specialist Surgery Series. Springer, Cham. https://doi.org/10.1007/978-3-030-55244-2_13

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  • DOI: https://doi.org/10.1007/978-3-030-55244-2_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-55243-5

  • Online ISBN: 978-3-030-55244-2

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